ID S5VRI3_STRC3 Unreviewed; 6187 AA.
AC S5VRI3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=NRPS protein {ECO:0000313|EMBL:AGS73342.1};
GN ORFNames=B446_32690 {ECO:0000313|EMBL:AGS73342.1};
OS Streptomyces collinus (strain DSM 40733 / Tue 365).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214242 {ECO:0000313|EMBL:AGS73342.1, ECO:0000313|Proteomes:UP000015423};
RN [1] {ECO:0000313|Proteomes:UP000015423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40733 / Tue 365 {ECO:0000313|Proteomes:UP000015423};
RA Ruckert C., Szczepanowski R., Goesmann A., Pross E.K., Musiol E.M.,
RA Blin K., Wohlleben W., Puhler A., Weber T., Kalinowski J.;
RT "The complete genome sequence of Streptomyces collinus Tu 365.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGS73342.1, ECO:0000313|Proteomes:UP000015423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40733 / Tue 365 {ECO:0000313|Proteomes:UP000015423};
RX PubMed=24140291; DOI=10.1016/j.jbiotec.2013.10.004;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Iftime D.,
RA Musiol E.M., Blin K., Wohlleben W., Puhler A., Kalinowski J., Weber T.;
RT "Complete genome sequence of the kirromycin producer Streptomyces collinus
RT Tu 365 consisting of a linear chromosome and two linear plasmids.";
RL J. Biotechnol. 168:739-740(2013).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP006259; AGS73342.1; -; Genomic_DNA.
DR RefSeq; WP_020943751.1; NC_021985.1.
DR STRING; 1214242.B446_32690; -.
DR KEGG; sci:B446_32690; -.
DR PATRIC; fig|1214242.5.peg.6702; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_8_11; -.
DR Proteomes; UP000015423; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19543; DCL_NRPS; 3.
DR CDD; cd19534; E_NRPS; 3.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 7.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR NCBIfam; TIGR01720; NRPS-para261; 3.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 5.
DR Pfam; PF00668; Condensation; 7.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 14.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000015423}.
FT DOMAIN 520..595
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1575..1649
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3081..3155
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4598..4672
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6096..6170
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1556..1576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1644..1664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6072..6098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6187 AA; 661049 MW; 2CDF850E5844CE4A CRC64;
MTDLHAQPPA APARPPAVPP PARAQHATRH VPLGEQFTRW VTRDPHAPAL TDGRRTWTYG
ELARRAARLA SHLVASGAGP ERTVALVLPR SMELIAAELA VALAGAAFLP VDPGYPAERR
ALMLADAAPA VVLDDPDLLR ALMDSGKQDP KAPESHVLPD HAAYVIYTSG STGTPKGVTV
THRGIGGFAA AAAERYAAGP GDRVLQFSSP SFDASVLELC VSVLSGALLV VPPDGPWLGD
ELAAVLDEHR ITHALIPPAA LATLPDPADT GGAPHLRTLI VGAEACPAAL VDRWAPGRRM
INSYGPTEAT VVATWTGPLT AGTGTPAIGS PLPGTEAHVL DAAMRPVPAG TEGELYVGGD
GLARGYLGRP GLTATRFVAH PFGPPGARLY RTGDRVRRRA DGELEFLGRA DRQVKVRGFR
IEPGEIETAL TRDPGVREAV VVVRDEEPAR GRLVGYVTPA DPARRPEPAR LRAALATVLP
AHMVPSAVVV LDAIPLTPQH KTDLRALPAP GGVPAEGHVE PRTDDERTLA GIWADVLGVH
TVGVTDDFFD LGGDSILAAR TLTRIRESLG VRLSLRDVFT ARTVAALAPL TAEPSAAAPP
DPITPAPRTG PVPLSSAQRR LWFLDDLAGG GAEYNTGVAL RLRGPLDTPA LRRALRRLAA
RHDSLRTTFA TVDGQGVQLV AAEAVLPLRT ADAGHLPDDR RDDAVERLLT EELRRPHDLT
TGPLTRALLV RRGAEDHVLL LAQHHIVTDG WSVGVLTRDL AALYHAETRG EPDGLPRPGV
QYPDFVLWER ARRAGDTDAD DLGYWKRRLA GLPHLELPTD RPRPAVRTTE GAAHRHDLPA
HLVDRLRRLA QGRGTTVFTL FAGAAAVLFS RCSGQRDVAF GTVTTGRDRR ELEDVTGFFA
NTVVLRGEVD DALTVDRFVE SMRATVLDAF AHDGVPFDRV VEELAPPRDP SRTPLVQVLV
VQQTAPERPP AAAGVRIEEH PLPRPAARFD LVFEFAPRAD GGCGLTVEYS TGLYDAATAA
RMSRQLHRLL EGMVDGPHRT VAELPLLSDD ERRTLLDSWN PPAPAGDPAD GATLPALFEA
QVRRTPDRTA VTCGGTRLDY AALNRRANRL ARMLTARGAG PESLVALCLP RSADLLPVLW
AVLKSGAGYL PVDPGYPAER IRHMLDDAAP ALVVATRATA HALPGDCEPL LLEDAEPSGD
GEADPTDADR IRPLHPSHPA YVIYTSGSTG RPKGVVVTHR SVAALAAWAR ETFGAQGLAH
VVASTSLNFD VSVFELLCPL LAGGGVEVVA DLPSLVDAPG PRKVGLLSGV PSVLSRVLGS
GGAVEADTVV LAGEALPART VRDIADVMPA AQVANLYGPT EATVYATAWF AHGTVPDQAP
PIGRPVAHTR AYVLDRLLRP QPPGVTGELY LGGGGLARGY LRRPGLTAAR FVADPFGAPG
DRMYRTGDLV RWSADGSLEY LGRIDQQVKV RGFRIELGEV EEALRHCAGV TEAAATVRDG
DGDGHRRLAG YVVAAPGARV DPEAVRRELG RTLPDYMVPA AVVVLPALPL NANGKLDRGR
LPEPAPAETA VRHVTPRTPT ERTLAAIWAD VLHVERVGAD DNFFALGGDS ILSIQVVAQA
RQAGLTITSR DVYRHQTVAA LARRADEAGS RGPAAAPAPV PATGSAPLTP IQRWLFDSAA
ERAGHFAQTL SVELRADVDA AALEAALGDV VAHHDALRSR FPADGTAVRW LIDGPAAPFR
LARHTGPDTD TPHLGPHDLP GGPMLRAVLH DRGSGRPPVL HLAVHHLVVD GVSWRLLLDD
LDLAYRARGT GGDGAVALPQ KSSPLRQWAE RLAAHAAAGG FDDEREYWTR ATDGARSGLP
SDRTGTNTYA SQRSVTVRLD PHATEALLRT LPETYRTRAN DVLLAALGRV LCGWTGHDRV
LVDVEGHGRE DLFADVDTSR TVGWFTTRHP VALAVPPEAD WDAVLKQVKE QLRAVPHHGL
GHGLLIRPGR DTAPLPATPA QISFNYLGRF GLSGTSEGLY GGLFRPLELD ADPSASRPHA
LEVVGRLDGD GLEFTWFYSD ELHRPETVED LAGRYADALA GLARHASRPG AAGRTPSDFP
LARLDQTHVD RIAGEHPADV EDVHPLTPTQ AGMLFHRLSQ DDRGVYFQQL TFVLDGVADP
AVLAEAWQRV TDRTPVLRAR VVWQDVTEPL LVVQRRAAVP VERPDWRGLS DAECDERLRA
LLDQDRARGV DLSRAPLQRL VLARVSDRAV RVVWSFDHLI LDGWSLFQVL SDVFACHAGL
TGTADAPLPD RRPFRDYVAW LRDRADRAEA ERHWHSRLDG LDGTTALPFD REPRESHRAE
STRAVRVTVP EATTRALRRL ARTAGLTMNT LVQGAWAVLL GRQAATDEVV FGTTVSGRPP
ELPGADAMTG LFIATLPTRV TVPRDEPLLT WLARLQQEQS EDRRHDHVPL HRMRAFTRLP
ERAALFDSIV VFENYPVDDA LAAAHGLRLT GLDGIETTNY PLSLVAYPGP ELTLRLGYDP
DLFDAATVER MAEYLTVLLD GLATAPGSTP ARLPLLTAAR REQVLHTWND TATDAPAATT
ADLFAAQVRR TPDAVALLAG DERLTYRELD DRAAALAARL AARGVRPEVP VGVLMDRSAG
LVVTQVALAR LGGVYVPLDG RAPRERLRTM LAEAGAGLLL TDGAWEETAT ALLPAEHVLR
PDDAGAAPAE PAAAPRVHPD NVQYLMFTSG STGAPKGVAV RQRDVTALAL DRAFTGHDRV
LVHSPHAFDA STYELWVPLL RGGTAVLAPP GDLEAAVVRR AITEQGVSCL FLTIGLFRLL
AQEDPACLSG AREVWTGGEA VPGSAVRRVL DACPGLTVVD VYGPTETTTF ATRRVFRAGD
ALPATLPIGR PLDDTRVYVL DGALQPQPPG IPGELYVAGA GLARGYTGRP GATAARYLAD
PFGPPGGRMY RTGDIVRWSA DGELHFVGRA DDQIKIRGFR VEPAEIEARI TGHPAIAEAV
VSVSRHAGRK RLVAHLVPAP GAAVPAAAEL RDRLSGDLPD YMIPAAFVTV AELPLTANGK
VDRRRLPAPD LSAAADTAYR APRTEAERVL AGIWAELLGV ERAGADDNFF MLGGDSIVSI
QVVSRARTAG LALTPRDVFR HPTLAALATA ATGATATVAG TAPVSGEAGL TPIQHWFLDA
EPPRPEYFNQ SVLVETAGAV DTDALAAALA ALWAHHDALR ARFTRAADGT WHQEITAADT
GAPRLLDVHD LHALDAEAAA QAEEHLSHEA HTGFRLDTGP LVAARLFTRA DGPARLLLAA
HHLIVDGVSW RVLLEDLETA YGQARAGEPI RLPGRTTSAR TWVQRLTRRT RAGEFAAQRA
HWEAVSRHCA APLPVDLDGG NTAGDLCAVT VRLDRRRTDD LLRRVPGVYR TRIDDVLLTA
LGRVLTDWTG RGTVAVGLEG HGREDQLFDD LDLSRTVGWF TSLFPVALRL PEGDWGAALK
SVKEQLRAVP DRGVGYGALR HLAGDEALAA APLPGISFNY LGRFDWSADG GALVGSVPGG
LGGAEDPGAP RPHLLDVVAR VEDDELEITW HYSGGRHREE TVHALAAGML RSLEEIVAHC
AAPDAGGRTP SDFPLARLDQ GAVDRIAGDG RTVEDVYPLT PMQAGMLFHS LMDAGARTYV
NQVQVVLHGV TDPHALAEAW RHTADATAIL RTRLVWQETA EPLQVVQRRA VLPVTHHDWS
GRSAEECARD MEALLDADRR AGIDLAAAPL TRLALIRLAP DRVRMVWTFH HVLLDGWSAA
QVFDEVCERY AALTAGRRPQ VPGRAPFADY LRWLAGRDTG RAERYWRGTL AGFTAPTALP
RDRRPADAHR TSSSGTVRVA LGPEVSARLK ETAQRAGLTV NTMLQGAWGL LLHHFGGGDD
VVFGTTVSGR PAELPGVTSM VGLFINTVPT RLRIDGRRPL LEWLREVQTA QSEARGHDFV
SLAQVQGWSE VPGGTNLFDS IVVFENYPFD AGALARHGLA VEQERDLEPT NYPLSVVVAP
GDDVTVSLDY DPQGFDAATV EGLGAALRTL LTSMADGAGH RLADLPVLAP DDGRRLLDRL
AGPVAEPPHR TLPDVFADQA ARTPDAPAVT AGAEHLTYRQ LNERADRLAR LLIEAGAGPE
RFVALALPRG ADLIVALLAV LKSGAAYLPV DPGHPADRIA FLFEDVRPDA VITCAETSAR
LPEGPYTRIA LDDAACAARL AAGSAAPVSD GERRSALLPE HPAYVIHTSG STGRPKGVVV
SHASVVALTD WAAAEFTGRG LDHVVASTSL NFDVSVFEIL SPLLAGGHVE LVRDVLALAE
RPGPWHAGLL SAVPSALGRL LAEDTVRVTA GTVVLAGEAL PARAVRQVHA AIPGCRVMNI
YGPTEATVYA TAFTCDPADP DRDPPIGRPV GGARAYVLDA RLRPVPTGAP GELYLAGTGV
ARGYLNRPGL TASRFLADPF GPPGGRMYRT GDLVRWTADG DLVYLGRTDD QVKVRGFRIE
LGEVEAVLAG HPEVAAAAAR VVEHEGHKRL VGYAVPRGGD TPAPADLRAF LARTLPDHLV
PAVVVPLERL PLGATGKLDR RALPEPVWSA PAAEGGRPPR TDGERTLAAI WSEVLGVADV
GATDNYFALG GDSILGIQIV SAARRAGLAL TPRHLFRHQT VAELAAAVEE APAATADAEQ
GPVTGDVPLT PVQHWLFDTL GGDPARLTQA VSYELAPGTD VPLLRAALAA VLERHDALRM
RCEQDADGRW RQYGTPPGAA PHLDVHDTPK EPAAVAAGLC AGFDLAKGPL LKAALCRPDG
HRPPVLVLAA HHLVVDAVSW RVLLEDLDTA HRALRAGATP ALGAKTTSFR TWARRLAAYT
ADGGFDDELA HWSALRPTAL PTDLDGGNAG ADEETVTVSL GEEDTRRLLQ EVPDAYRTRV
NDVLLCAVGR VLARWTGQDR VVLALEGHGR EDLFDDVDLS RTVGWFTTMF PVGLDVPRDA
DLATALKTVK ENLRGVPRGG VGYGALRHLH PTAGRALPGL PQVGFNYLGQ QDRTGPADGL
LRAPHDGLTG GMDPSADRPH LLDVLGRVSG GRLEFTWSYS RRAHRHDTVA RLARETAQEL
REIVRHCSAP GAGGRTPSDF PLAALDQRAV DRLAGDGRDV TDVYPLTPTQ TGMVVHGMDE
PGEGLYVEQI TFVADGVREP RLLAAAWQHV VDRTPVLRTA VALGELPVPL QTVHRHVTLP
VTELDWSGLD PARRRTALER LLDEDRARGL ALDHPPLLRV TLIRLGPDEV RVVWTFHHVL
LDGWSVFHVL SDVMAAHAAL AAGGEPELPP RRPFADYAAW LAGRDAAAAE EHWKTALAGY
AAPTALPYDR RPAPGAAARS GTWLSRRLGA DGTARLTDFA RRHRLTLNTL VQGAWALLLA
RAGGEREVCF GTTVSGRPAD LAGADTITGL FITTLPARIT VDESTPCAAW LRELQAARAE
DRRFDHVPLT DLHQWSELPP GTSLFDSLLV FENYPVGDAT AGAHGVRIRD LDAREATNYP
LTVVISPGDE LSVELGYDPR YFDEATAEAL AARLTHTLTA LAASGDRAPL YTVDVLPPAE
RHRLLHGPAR PHLPPVPPAT LPALFETAAD RWPDRTALDT GESTLTFGEA EAHANRLAHR
LLARGAGPGD LVALVLARSA DMALAQLAVT KAGAAFVPVD PGYPAERVAL MLRDADPAVT
LTAEEVAGLL AAPPDGTPAH RPTDADRVRP LQLDDPAYVI YTSGSTGTPK GVVVTHRGLA
GFAAAEAAHY RVSAGDRVLA FATPSFDASV LELCMAWPSG AALVVPPPGP LLGADLAGFL
RTGRITHTLL PPAALATLPP DTPGTLPDLR TLIVGADACR AELAARWAPH HRMVNSYGPT
EATVVATWSD PLVPDGGAPP IGRALPATGA YVLDARLRPV PDGVPGELWL AGPALARGYL
GRPGLTATRF TADPFGPPGT RMYRTGDLVR RDARGELHYL GRTDHQLKLR GHRIEAGEVE
ATLVRHPAVL DAVVSVREDE PGLPRLVAHL LVAPGAEPPS AAQLRAFAAR TLPGPMVPSA
FVTLDRFPLT ENGKTDRAAL PAPGPLAEEP AAGHVPPRTP TEEAVAALWE EALETAVGAE
DDFFDLGGDS LRALQIASRA NDLFGVTLTP RDVLVNRTVA ALADLVEEQV LSELEDAARG
DSDHEER
//
