ID T1FYS7_HELRO Unreviewed; 408 AA.
AC T1FYS7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
GN Name=20213975 {ECO:0000313|EnsemblMetazoa:HelroP66900};
GN ORFNames=HELRODRAFT_66900 {ECO:0000313|EMBL:ESN98974.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP66900, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98974.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP66900}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01001085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097143; ESN98974.1; -; Genomic_DNA.
DR RefSeq; XP_009022489.1; XM_009024241.1.
DR AlphaFoldDB; T1FYS7; -.
DR STRING; 6412.T1FYS7; -.
DR EnsemblMetazoa; HelroT66900; HelroP66900; HelroG66900.
DR GeneID; 20213975; -.
DR KEGG; hro:HELRODRAFT_66900; -.
DR CTD; 20213975; -.
DR eggNOG; KOG0129; Eukaryota.
DR HOGENOM; CLU_014948_1_2_1; -.
DR InParanoid; T1FYS7; -.
DR OMA; QACTHDY; -.
DR OrthoDB; 2897681at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0008135; F:translation factor activity, RNA binding; IBA:GO_Central.
DR GO; GO:2000766; P:negative regulation of cytoplasmic translation; IBA:GO_Central.
DR CDD; cd19757; Bbox1; 1.
DR CDD; cd12723; RRM1_CPEB1; 1.
DR CDD; cd12725; RRM2_CPEB1; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.640.40; Cytoplasmic polyadenylation element-binding protein, ZZ domain; 1.
DR InterPro; IPR032292; CEBP1_N.
DR InterPro; IPR032296; CEBP_ZZ.
DR InterPro; IPR038446; CEBP_ZZ_sf.
DR InterPro; IPR034819; CPEB.
DR InterPro; IPR034977; CPEB1_RRM1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR12566; CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB; 1.
DR PANTHER; PTHR12566:SF9; CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1; 1.
DR Pfam; PF16368; CEBP1_N; 1.
DR Pfam; PF16366; CEBP_ZZ; 1.
DR Pfam; PF16367; RRM_7; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 146..241
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 263..344
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 14..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 408 AA; 45731 MW; CFEAE89D19D312FD CRC64;
MSNNSHTAIL DLFNATRSMS PPDSDTSGVS TGSEISEAAL PGNGNMSPTI DLLKALGLQS
DIPMQRQVGH GMQQQPLYND FSMSADLFAS RPWTSLNTLF STSATDPYSI ERAAKLYRNA
ATISEPTCTW SGQLPMKIYR NPVYSFKVFL GGVPWDITEA GLQSCFRSFG ALKIEWPGKD
GKHPRYPIKG KELPVGYVYI LFESERSVRS LLQACTHDFS NGGEYYFKIS SKRMRSKEVQ
VIPWIISDSN YVKSPSQRLE PQKTVFVGAL HGMLNAEGLA HILNDLFGNV VYAGIDTDKH
KYPIGSGRVT FSSHKSYVKA VTAAFVEIKT AKFTKKIQID PYLEESQCNV CQKEHGVYFC
RDFNCFLYYC RSCWQTYHSS DNTRYHKPLM RNNKSSAKCC PVVELPPV
//
