ID T1X6N6_VARPD Unreviewed; 197 AA.
AC T1X6N6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=2-hydroxychromene-2-carboxylate isomerase {ECO:0000256|PIRNR:PIRNR006386};
DE EC=5.99.1.4 {ECO:0000256|PIRNR:PIRNR006386};
GN ORFNames=VAPA_1c08790 {ECO:0000313|EMBL:AGU47999.1};
OS Variovorax paradoxus B4.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=1246301 {ECO:0000313|EMBL:AGU47999.1, ECO:0000313|Proteomes:UP000016223};
RN [1] {ECO:0000313|EMBL:AGU47999.1, ECO:0000313|Proteomes:UP000016223}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B4 {ECO:0000313|EMBL:AGU47999.1,
RC ECO:0000313|Proteomes:UP000016223};
RA Schuldes J., Brandt U., Hiessl S., Wuebbeler J.H., Thuermer A.,
RA Steinbuechel A., Daniel R.;
RT "Genome sequence of Variovorax paradoxus B4.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-
CC oxobut-3-enoate; Xref=Rhea:RHEA:27401, ChEBI:CHEBI:59350,
CC ChEBI:CHEBI:59353; EC=5.99.1.4;
CC Evidence={ECO:0000256|PIRNR:PIRNR006386};
CC -!- SIMILARITY: Belongs to the GST superfamily. NadH family.
CC {ECO:0000256|PIRNR:PIRNR006386}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003911; AGU47999.1; -; Genomic_DNA.
DR RefSeq; WP_021005549.1; NC_022247.1.
DR AlphaFoldDB; T1X6N6; -.
DR KEGG; vpd:VAPA_1c08790; -.
DR PATRIC; fig|1246301.3.peg.894; -.
DR HOGENOM; CLU_069253_1_3_4; -.
DR OrthoDB; 8560325at2; -.
DR Proteomes; UP000016223; Chromosome 1.
DR GO; GO:0018845; F:2-hydroxychromene-2-carboxylate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:1901170; P:naphthalene catabolic process; IEA:InterPro.
DR CDD; cd03022; DsbA_HCCA_Iso; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR001853; DSBA-like_thioredoxin_dom.
DR InterPro; IPR014440; HCCAis_GSTk.
DR InterPro; IPR044087; NahD-like.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR42943; GLUTATHIONE S-TRANSFERASE KAPPA; 1.
DR PANTHER; PTHR42943:SF2; GLUTATHIONE S-TRANSFERASE KAPPA 1; 1.
DR Pfam; PF01323; DSBA; 1.
DR PIRSF; PIRSF006386; HCCAis_GSTk; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|PIRNR:PIRNR006386};
KW Transferase {ECO:0000313|EMBL:AGU47999.1}.
FT DOMAIN 4..195
FT /note="DSBA-like thioredoxin"
FT /evidence="ECO:0000259|Pfam:PF01323"
FT ACT_SITE 13
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006386-1"
SQ SEQUENCE 197 AA; 21563 MW; AC302F3E284DC9F0 CRC64;
MTKTVEFYFD FGSPAAYLAA TQLPHVCADT GAELVWKPML LGGVFQATGN RSPAEVVPKG
PYMTIDLKRF ARRYGVPFVH NPHFPINTLL LMRGATGLQM KEPARLGAYV DAVFHAMWVE
PKNMNDPATV AAVLQNAGFD ATALLALAGT QEVKDRLRAV TQEAVARGVF GAPTMFVGDQ
MFWGQDRLDF VREALDA
//
