ID U9W589_NEUCR Unreviewed; 515 AA.
AC U9W589;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=4-aminobutyrate aminotransferase {ECO:0000256|ARBA:ARBA00018543};
DE EC=2.6.1.19 {ECO:0000256|ARBA:ARBA00012912};
DE AltName: Full=GABA aminotransferase {ECO:0000256|ARBA:ARBA00031787};
DE AltName: Full=Gamma-amino-N-butyrate transaminase {ECO:0000256|ARBA:ARBA00030204};
GN ORFNames=NCU08998 {ECO:0000313|EMBL:ESA43414.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA43414.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:ESA43414.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805}, and OR74A
RC {ECO:0000313|EMBL:ESA43414.1};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [2] {ECO:0000313|EMBL:ESA43414.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OR74A {ECO:0000313|EMBL:ESA43414.1};
RG The Broad Institute Genome Sequencing Platform;
RA Galagan J., Henn M.R., Hood H., Radford A., Collins R.A., Walker B.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA Allen A.W., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B., Chen Z.,
RA Gainer-Dewar J., Gnerre S., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J.B., McCowan C., Murphy C.,
RA Pearson M.D., Poon T.W., Priest M., Roberts A., Saif S., Shea T.D.,
RA Sisk P., Shea T., Sykes S., Zucker J., Kodira C., Bowman B., Colot H.,
RA Ebbole D., Rasmussen C., Baker C., Kalkman E., Chen C.-H., Shi M.,
RA Mathur R., Lambreghts R., Collopy P., Mehra A., Schweredtfeger C., Hong C.,
RA Belden W., Glass N.L., Borkovich K., Dunlap J., Lander E., Wortman J.,
RA Nusbaum C., Sachs M., Birren B.;
RT "The Genome Sequence of Neurospora crassa strain OR74A.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate
CC semialdehyde; Xref=Rhea:RHEA:23352, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:57706, ChEBI:CHEBI:59888; EC=2.6.1.19;
CC Evidence={ECO:0000256|ARBA:ARBA00000442};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000256|ARBA:ARBA00008954,
CC ECO:0000256|RuleBase:RU003560}.
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DR EMBL; CM002238; ESA43413.1; -; Genomic_DNA.
DR EMBL; CM002238; ESA43414.1; -; Genomic_DNA.
DR RefSeq; XP_011393979.1; XM_011395677.1.
DR RefSeq; XP_011393980.1; XM_011395678.1.
DR AlphaFoldDB; U9W589; -.
DR STRING; 367110.U9W589; -.
DR EnsemblFungi; ESA43413; ESA43413; NCU08998.
DR EnsemblFungi; ESA43414; ESA43414; NCU08998.
DR GeneID; 3875148; -.
DR KEGG; ncr:NCU08998; -.
DR VEuPathDB; FungiDB:NCU08998; -.
DR InParanoid; U9W589; -.
DR OrthoDB; 177625at2759; -.
DR Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0003867; F:4-aminobutyrate transaminase activity; IBA:GO_Central.
DR GO; GO:0034386; F:4-aminobutyrate:2-oxoglutarate transaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR GO; GO:0009450; P:gamma-aminobutyric acid catabolic process; IBA:GO_Central.
DR GO; GO:0006536; P:glutamate metabolic process; IEA:EnsemblFungi.
DR CDD; cd00610; OAT_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR004631; 4NH2But_aminotransferase_euk.
DR InterPro; IPR005814; Aminotrans_3.
DR InterPro; IPR049704; Aminotrans_3_PPA_site.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR00699; GABAtrns_euk; 1.
DR PANTHER; PTHR43206:SF1; 4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43206; AMINOTRANSFERASE; 1.
DR Pfam; PF00202; Aminotran_3; 1.
DR PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000256|ARBA:ARBA00022576,
KW ECO:0000313|EMBL:ESA43414.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|RuleBase:RU003560};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Transferase {ECO:0000256|ARBA:ARBA00022576, ECO:0000313|EMBL:ESA43414.1}.
SQ SEQUENCE 515 AA; 56801 MW; BCF4EFEE88713221 CRC64;
MASRLLRSSY SGSLRAVSTA STVRPAAVSA VHQFSNRRQF TASSSKMASS FYKDWEPEGP
TVKTEIPGPK AKEAIKELDE VFDTRSLNML TDYHKSVGNY IADPDGNVLL DVYAQIASIP
IGYNNPVLQD AARSSDMVNS IINRPALGNF PPTDWASVLK TGILKVAPKG LNQVFTAMAG
SDANETAYKA AFMWRRQKER GGPQVEFTAE EMESAMINQS PGASSLSILS FKSAFHGRLF
GSLSTTRSKP IHKLDIPAFD WPQATFPLLK YPLEEHAEEN AAAEQAALDE VEHLIKNYHI
PPAAVIIEPI QSEGGDNHAS PAFFRGLRAI TKKHGVLLIV DEVQTGVGAT GKFWAHEHWD
LQDPPDMVTF SKKAQTAGYY FGNPELRPNK PYRQFNTWMG DPARALLFKA IIGEIERLGL
VEHTARVGDY LYGKLEGLAQ KYPGQFANLR GKGQGTFIAF DNPRRDEFLA RAKKFGVNIG
GSGQSAVRLR PMLIFEEKHA DILVDALEKI VKSFQ
//
