ID W5PZE4_SHEEP Unreviewed; 223 AA.
AC W5PZE4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Glutathione S-transferase {ECO:0000256|RuleBase:RU003494};
DE EC=2.5.1.18 {ECO:0000256|RuleBase:RU003494};
GN Name=GSTA1-1 {ECO:0000313|Ensembl:ENSOARP00000015830.1};
GN Synonyms=GSTA2 {ECO:0000313|EMBL:WNN92443.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015830.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015830.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015830.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|EMBL:WNN92443.1}
RP NUCLEOTIDE SEQUENCE.
RA Qiu L.-X., Cao X., Yang H.;
RT "Cloning and sequence analysis of GSTA2 gene in sheep.";
RL Submitted (AUG-2023) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSOARP00000015830.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC Evidence={ECO:0000256|RuleBase:RU003494};
CC -!- SIMILARITY: Belongs to the GST superfamily. Alpha family.
CC {ECO:0000256|ARBA:ARBA00011055, ECO:0000256|RuleBase:RU003494}.
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DR EMBL; AMGL01058955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; OR440604; WNN92443.1; -; mRNA.
DR RefSeq; XP_011956243.1; XM_012100853.2.
DR AlphaFoldDB; W5PZE4; -.
DR SMR; W5PZE4; -.
DR STRING; 9940.ENSOARP00000015830; -.
DR PaxDb; 9940-ENSOARP00000015830; -.
DR Ensembl; ENSOART00000016063.1; ENSOARP00000015830.1; ENSOARG00000014759.1.
DR GeneID; 443054; -.
DR KEGG; oas:443054; -.
DR CTD; 443054; -.
DR eggNOG; KOG1695; Eukaryota.
DR HOGENOM; CLU_039475_4_0_1; -.
DR OMA; RMESIGW; -.
DR OrthoDB; 3412208at2759; -.
DR Proteomes; UP000002356; Chromosome 20.
DR Bgee; ENSOARG00000014759; Expressed in adult mammalian kidney and 51 other cell types or tissues.
DR GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR CDD; cd03208; GST_C_Alpha; 1.
DR CDD; cd03077; GST_N_Alpha; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR003080; GST_alpha.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11571; GLUTATHIONE S-TRANSFERASE; 1.
DR PANTHER; PTHR11571:SF107; GLUTATHIONE S-TRANSFERASE A2; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF02798; GST_N; 1.
DR PRINTS; PR01266; GSTRNSFRASEA.
DR SFLD; SFLDG01205; AMPS.1; 1.
DR SFLD; SFLDG00363; AMPS_(cytGST):_Alpha-__Mu-__Pi; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transferase {ECO:0000256|RuleBase:RU003494}.
FT DOMAIN 3..83
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 85..208
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
SQ SEQUENCE 223 AA; 25390 MW; ABF073A1FB3E9EEF CRC64;
MAGKPKLHYF NGRGRMECIR WLLAAAGVEF EEKFIEQPED LDKLKNDGSL MFQQVPMVEI
DGIKLVQTRA ILNYVATKYN LYGKDMKERA LIDMYSEGVA DLGEMILLLP LCPPDQKDAK
IAQIKQSTTN RYLPAFEKVL KSHGQDYLVG NKLSKADIHL VELLYLVEEL DPSLLANFPL
LKGLKARVSN LPAVKKFLQP GSQRKPPMDE KTLEEAKRIF RIK
//
