KEGG   Tupaia chinensis (Chinese tree shrew): 102494943
Entry
102494943         CDS       T02978                                 
Symbol
DOT1L
Name
(RefSeq) DOT1 like histone lysine methyltransferase
  KO
K11427  [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]
Organism
tup  Tupaia chinensis (Chinese tree shrew)
Pathway
tup00310  Lysine degradation
tup01100  Metabolic pathways
tup05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:tup00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    102494943 (DOT1L)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    102494943 (DOT1L)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:tup03036]
    102494943 (DOT1L)
Enzymes [BR:tup01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.360  [histone H3]-lysine79 N-trimethyltransferase
     102494943 (DOT1L)
Chromosome and associated proteins [BR:tup03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     102494943 (DOT1L)
   HMT complexes
    Dot1-containing complex
     102494943 (DOT1L)
SSDB
Motif
Pfam: DOT1 HALZ
Other DBs
NCBI-GeneID: 102494943
NCBI-ProteinID: XP_014441023
Position
Un
AA seq 1526 aa
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHVLQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCR
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNATTPTKVP
ESRVAGPVDAPVDSGAEDDKAGATTVKKPSPSKARKKKLNKKGRKLAGRKRGRPKKLSTA
NPERKPKKSQAALELLHAQTVSQTAPSSPQDAYRSPHSPFYQLPPSAPRPCPTPLLAAPT
PPALQKLLESFKIQYLQFLAYTKTPQYRANLQQLLDQEKERNAQLLGAAQQLLSHCQAQK
EEIRGLFQQKLDELGVKALTYDDLIQAQKEISAHNQQLQEQSEQLEKDNCQLRSRSLQLL
KARCEELRLDWSTLSLESLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLR
SCVPPDDGLVPPPRGKGALGRELEAEAGRLHLELDCAKFSLPPFSVSPELSMNGHGAGYE
LGGPLSRPASKQSTPQYLASPPDQEVVPCTPSHGSRPRLEKLSSLALPDYTRLSPAKIVL
RRHLSQDPAGAGKTGTGELHSRAEHAKENGLTYQSPGVPSVKLSPQDPRPPSPGPTQAAG
EKGGEKPAKERGHGSSGEPITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAEKLRSTPS
PVPQPRDSSALEKPGGANAHGAGSKSLAAAPAGFYAGSVAISGALSGSPAPLAPGAELAA
FDESSSSGSLLGAVGSRSSTPQHPPPLAQPRPPGQASPVHRLAASPRLGGAAPGLLPEPG
KADLPSDAGFSDPEGEAKRRIVFTISAAAASARQSPSSKHSPLPSGARGDCGQGYGQDSR
KRGRRKRASAGTPSLSTGVSPKRRALPAVAGLFTQSSGSPLNLSSMVSTINQPLEITAIS
SPEDSRKSSPVPCQDHDQPPVLKKERPLSQANGAHYSPLTSDEEPGSEDEPSSARIERKI
ATISLESKSPPKTLETGGGMAGRRPTPASEPVVSSKWKSTFSPISDVGPAKPADGPLQAP
TLGQASLLAFRPTLDEPAAAEAKLVAHPRKSFPGALAGADGLSPGTNPXNGLAFGGGLAA
DLSLHSFNDGAPLPLRVPEASLSFPAPRGREGPSEANPFLNKRQLDGLCGLKAEAGKGRE
AAEDFRSGRNLFISAAAVPSGGLLGGPGLATAASSAGSTPPSAQTHRPFLGAFPPGPQFS
LGPVSLQANLSSVAGSSVLQSLFSTVPAAAGLAPATSATTRLTNSHAVGSFSGVTGGAVG
AGRKDAASTVNGGAPGGAGLAQLYCP
NT seq 4581 nt   +upstreamnt  +downstreamnt
atgggcgagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaagcaccacgatgctgctcacgagatcatcgagacc
atccggtgggtctgcgaggagatcccggatcttaaactcgccatggagaactacgtcctg
atcgactacgacaccaagagcttcgagagcatgcagcggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacgcagcccatgaagctgaacacg
aggccgtccaccgggctgctgcggcacgtcctgcagcaggtgtacaaccactcggtcacc
gaccccgagaaactcaacaactacgagcccttctcccccgaggtctatggcgagacctcc
ttcgacctggtggcccagatgatcgacgagatcaagatgaccgaggacgacctcttcgtg
gacctgggcagcggtgtgggccaggtcgtgctccaggttgctgccgccaccaactgcaga
caccactacggcgtcgagaaagccgacatcccagccaagtacgcggagaccatggaccgc
gaattcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggtgacttcctctccgaggagtggcgggagcggatcgccaacacaagtgttatctttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcgcttcgcaaacatg
aaggagggtggcagaatcgtgtcctcgaaaccctttgcacctctaaacttcaggataaac
agccggaacttgagtgacattggcaccatcatgcgtgtggtggagctgtcgcccctgaag
ggctccgtgtcgtggacggggaagccggtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggaacaagaggcg
gcccggcgccggcagcagcgggagagcaagagcaacgccaccactccgaccaaggtcccc
gagagccgggtggccggccccgtggacgcccccgtggattctggtgctgaggacgacaag
gcgggagcgaccaccgtcaagaagccgtctccctccaaagctcgcaagaagaagctgaac
aagaaggggaggaagctggctggccggaagcgcgggcgcccgaagaagctgagcaccgcg
aaccccgagcgcaagcccaagaagagccaagctgcactggagctgctgcacgcacagacg
gtgtcccagacggccccctcctcgccccaggacgcctacaggtccccgcacagcccgttc
taccagctacctccgagcgcaccacggccgtgccccaccccactgctggcggcgcccacc
ccacctgcactgcagaagctgctagagtcctttaagatccagtacctgcagttcctggcc
tacaccaagaccccccagtacagagccaacctgcagcagctgctggaccaggagaaggag
aggaacgcccagctgctgggtgccgcgcagcagctcctcagccactgccaggcccagaag
gaggagatccgggggctgttccagcagaaactggacgagctgggcgtgaaggccttgacc
tacgatgacctgatccaagcgcagaaggagatctctgcgcacaaccagcagctgcaggag
cagtcggagcagctggagaaggacaactgtcagctccgcagccgcagcctgcagctgctc
aaggctcggtgcgaggagctgaggctggactggtccacgctgtccctggagagcctgctg
aaggagaagcaggccctgaagagccagatctccgagaagcagcgtcactgcctggagctg
cagatcagcatcgtggagctcgagaagagccagcggcagcaggagctgctgcagctcagg
tcctgcgtgccgcccgacgatgggctggtgccgcccccgcgcgggaagggtgccttgggc
cgcgagctggaggccgaggcgggccggctgcacctggagctggactgcgccaagttctcc
ctgccacccttcagcgtgagccccgagctgtccatgaacggccacggggcgggctacgag
ctgggcggcccgctgagccggccggcgtccaagcagagcaccccgcagtacctggcctcc
ccgcccgaccaggaggtggtgccctgcacgcccagccacggcagccggccccggctggag
aagctgtccagcctggccctgcctgactacaccaggctctcgccggccaagatcgtgctg
cggcggcacctgagccaggaccctgcgggtgctggcaagacgggaaccggcgagctccac
tctcgagctgagcacgccaaggagaacggcctcacctaccagagccccggcgtgccgagt
gtgaagctgagccctcaggacccgcggcccccgtccccagggcccacgcaggctgcaggg
gagaagggcggtgagaagcctgcgaaggagcgcggccacggcagcagcggcgagcccatc
accagcttgcccatcagcatcccgctcagcaccgtgcagcccaacaagctcccggtcagc
attcccctggctagcgtggttctgcccagccgcgccgagaagctgaggagcacgcccagc
cccgtgccgcagccccgagactcatctgcgctcgagaaaccgggcggcgctaatgcccat
ggggccgggagcaagagcttggccgcggcccccgcaggcttctacgccggctccgtggcc
atcagtggggccctgtccggcagcccggcacccctggcccccggagccgagctggccgcc
ttcgacgagtcctccagttcagggagcctcctcggtgccgtggggtcccggagctcgacg
ccgcagcacccgcccccgctggcgcagccccgcccccctggccaggcctcgcccgtgcac
cggctggccgccagtccccggctgggtggggccgccccgggcctcctccccgaacccggc
aaggccgacctgccctctgatgccggcttctcggacccggagggcgaagccaagcggagg
atcgtcttcaccatctcagccgcggctgccagcgccaggcagtcaccctccagcaagcac
agccctctgccctcgggagcccgaggggactgtggtcagggctacgggcaggacagccgc
aagcggggccgcaggaagagggcgtcggccgggacaccgagcctgagcacaggcgtgtct
cccaagcgccgtgccctgccagctgtcgccgggctcttcacgcagtcctcggggtcgccc
ctcaacctctcctccatggtcagcaccatcaaccagcccctggagatcacggcgatctcc
tcccccgaggactcacggaagagctcccctgtgccctgccaggaccacgaccagccgcct
gtgctcaagaaggagcggcccctgagccaggccaacggggcgcactactccccgctgacc
tccgacgaggagccgggctccgaggacgagcccagcagtgcccgaattgaaaggaaaatc
gcgacgatttccttggagagcaagtctcccccgaagaccttggagactgggggtggcatg
gcgggccggaggccgacacccgccagcgagcctgtcgtcagcagcaagtggaagtccacc
ttctcgcccatctccgacgtcggcccggccaagcccgcggacggccctctgcaggccccc
accctgggccaggcctccctgctcgccttccggcccaccctggacgagccggcggccgcg
gaggccaagctcgtcgcgcaccccaggaagagctttcccggcgccttggcgggggccgac
gggctcagccccggcaccaaccccngcaacggcttggccttcggcggcggtctggccgcg
gacctcagtttacacagcttcaacgatggtgctcccctccccctccgggtccccgaggcc
tcgctcagcttccccgccccgcggggcagggagggcccctcggaagccaacccctttctg
aacaagcggcagctggacggcctgtgcggcctgaaggccgaggcgggcaagggcagggag
gcggccgaggacttcaggagcggccgcaacctcttcatctccgccgccgccgtgccctcc
gggggcctcctgggcggccctggcctggccacagcggcgtcgtccgcgggcagcacgccg
ccctccgcacagacgcaccggcctttcctgggtgcctttccgcctggaccgcagttctcc
ctggggcccgtgtccctgcaggccaacctcagctctgtggccggctcgtcggtgctgcag
tccctgttcagcaccgtgccggccgccgcgggcctggcgcccgccacctctgccacgacc
agactgaccaactcccacgccgtgggcagcttctccggggtgacgggcggagcagtcgga
gcaggacggaaggacgcggcctctactgtgaacggcggcgctcccggaggcgccgggctg
gcccagctgtactgtccatag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (50)   
   KEGG ORTHOLOGY (1)   
   RefGene (46)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (2)   
   Pfam (2)   
All databases (75)   

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