KEGG   Ursus maritimus (polar bear): 103656833
Entry
103656833         CDS       T03271                                 
Symbol
TBK1
Name
(RefSeq) serine/threonine-protein kinase TBK1 isoform X1
  KO
K05410  TANK-binding kinase 1 [EC:2.7.11.10]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr04014  Ras signaling pathway
umr04137  Mitophagy - animal
umr04140  Autophagy - animal
umr04620  Toll-like receptor signaling pathway
umr04621  NOD-like receptor signaling pathway
umr04622  RIG-I-like receptor signaling pathway
umr04623  Cytosolic DNA-sensing pathway
umr04657  IL-17 signaling pathway
umr04936  Alcoholic liver disease
umr05014  Amyotrophic lateral sclerosis
umr05022  Pathways of neurodegeneration - multiple diseases
umr05135  Yersinia infection
umr05160  Hepatitis C
umr05161  Hepatitis B
umr05162  Measles
umr05163  Human cytomegalovirus infection
umr05164  Influenza A
umr05165  Human papillomavirus infection
umr05167  Kaposi sarcoma-associated herpesvirus infection
umr05168  Herpes simplex virus 1 infection
umr05169  Epstein-Barr virus infection
umr05170  Human immunodeficiency virus 1 infection
umr05171  Coronavirus disease - COVID-19
umr05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:umr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    103656833 (TBK1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103656833 (TBK1)
   04137 Mitophagy - animal
    103656833 (TBK1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    103656833 (TBK1)
   04621 NOD-like receptor signaling pathway
    103656833 (TBK1)
   04622 RIG-I-like receptor signaling pathway
    103656833 (TBK1)
   04623 Cytosolic DNA-sensing pathway
    103656833 (TBK1)
   04657 IL-17 signaling pathway
    103656833 (TBK1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103656833 (TBK1)
   05161 Hepatitis B
    103656833 (TBK1)
   05160 Hepatitis C
    103656833 (TBK1)
   05171 Coronavirus disease - COVID-19
    103656833 (TBK1)
   05164 Influenza A
    103656833 (TBK1)
   05162 Measles
    103656833 (TBK1)
   05168 Herpes simplex virus 1 infection
    103656833 (TBK1)
   05163 Human cytomegalovirus infection
    103656833 (TBK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103656833 (TBK1)
   05169 Epstein-Barr virus infection
    103656833 (TBK1)
   05165 Human papillomavirus infection
    103656833 (TBK1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    103656833 (TBK1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    103656833 (TBK1)
   05022 Pathways of neurodegeneration - multiple diseases
    103656833 (TBK1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103656833 (TBK1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    103656833 (TBK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:umr01001]
    103656833 (TBK1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:umr04131]
    103656833 (TBK1)
Enzymes [BR:umr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     103656833 (TBK1)
Protein kinases [BR:umr01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   103656833 (TBK1)
Membrane trafficking [BR:umr04131]
 Autophagy
  Xenophagy
   Other xenophagy associated proteins
    103656833 (TBK1)
SSDB
Motif
Pfam: TBK1_CCD1 Pkinase TBK1_ULD PK_Tyr_Ser-Thr Pkinase_fungal ABC1 Kinase-like CEP63 DUF713 ubiquitin COG6_N
Other DBs
NCBI-GeneID: 103656833
NCBI-ProteinID: XP_040493155
UniProt: A0A384BJL2
Position
Unknown
AA seq 729 aa
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPISCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMTIHVFSLQQMTAHKIYIHSYNTATVFHELVYKQTKIISSNQELIYEGRRLV
IEPGRLAQHFPKTTEEDPIFVVSREPLSTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACKIASTLLLYQELMRKGIRWLIELVKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIESKLSPGGLLADTWAHQE
GTHPKDRHVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTEECVKKYEAFLDKSEEWMRKMLHLRKQLLSLTSQCFDIEEEVSKYQDYTNELQETLPQ
KMFAASSGIKHTMTPIYPCSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
NT seq 2190 nt   +upstreamnt  +downstreamnt
atgcagagcacgtctaatcatctgtggcttttatcggatattttaggccaaggagctact
gcaaatgtctttcgtggaaggcacaagaaaaccggtgacttatttgctatcaaagtattt
aataacataagcttccttcgtccagtggatgttcaaatgagagaattcgaagtgttgaag
aaactcaatcacaaaaatattgtcaaattatttgctattgaagaggagacaacaacaaga
cataaagtacttattatggaattttgtccatgtggaagtttatacactgttttagaagag
ccatctaatgcctatggactaccagagtctgaatttttaattgttttacgagatgtggtc
ggtggaatgaatcatctccgagagaatggcattgtgcaccgtgatatcaagccaggaaat
atcatgcgtgttataggggaggatggacagtctgtgtacaaactcacagattttggcgca
gctagagaattagaagatgatgagcagtttgtttctctgtatggcacagaagaatatttg
catcctgatatgtatgagagagcagtactgagaaaagatcatcagaagaaatatggagca
acagttgatctttggagcattggggtaacattttaccacgcggctaccgggtcactgcca
tttagaccatttgaagggccacgtaggaataaggaagtgatgtataaaataattactgga
aagccttctggtgcaatatctggagtacagaaagcagaaaatggaccaatcgactggagt
ggagacatgcctatttcttgtagtctttctcggggtcttcaggttctacttacccctgtt
cttgcaaacatcctggaggcagatcaggaaaagtgttggggttttgaccagttttttgca
gaaactagtgatatacttcatcgaatgaccattcatgttttttcgctgcaacaaatgaca
gctcataagatttatattcatagctataatactgctactgtatttcatgaactggtgtat
aaacaaaccaaaattatttcttcaaatcaagaacttatctatgagggacgacgtttagtc
atagaacctggaagactggcacagcatttccctaaaactacggaggaagatcccatcttt
gtagtaagccgggaacctctgagtaccataggattgatatatgaaaaaatttccctccct
aaagtacatccacgttacgatttagatggggacgctagcatggctaaggcaataacagga
gttgtgtgttatgcctgtaaaattgccagtaccttgctgctttatcaggaattaatgcga
aaggggatacgatggttgatagaattagtaaaagatgattataatgaaactgttcacaaa
aagacagaagttgtgatcaccttggatttctgcatcagaaacattgaaaaaactgtgaaa
gtatatgaaaagttgatgaagatcaatctagaagcagcagagttaggtgaaatttcagac
atacacaccaaattgttgagactttccagttctcagggaacaatagaaaccagtcttcag
gatatcgaaagcaaattatctccaggtggattgctggcagatacctgggcccatcaagaa
ggcactcatccaaaagatagacatgtagaaaagctacaagtcctgctaaattgcatcaca
gagatttactatcagttcaaaaaagacaaagcagaacgtcgattagcttataatgaagaa
cagatccacaaatttgataagcaaaaactgtattaccatgcaacaaaagctatgacccac
tttacagaggaatgtgttaagaaatatgaggcatttttggataagtcagaagaatggatg
agaaagatgcttcatcttaggaaacagttattatccctaactagtcagtgttttgatatc
gaagaagaagtatcaaagtatcaagactacacaaatgagttacaagaaactttgccccag
aaaatgtttgcagcctccagtggaatcaagcataccatgaccccaatttatccatgttct
aatacattagtggaaatgactcttggtatgaagaaattaaaggaagaaatggaaggggta
gttaaagaacttgctgaaaataatcatatcttagaaaggtttggctctttaaccatggat
ggcggccttcgcaatgttgactgtctttag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (24)   
   KEGG PATHWAY (24)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (6)   
   RefSeq(nuc) (4)   
   GenBank (1)   
   EMBL (1)   
Protein domain (11)   
   Pfam (11)   
All databases (56)   

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