KEGG   Ursus maritimus (polar bear): 103674739
Entry
103674739         CDS       T03271                                 
Symbol
CACNA1D
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1D isoform X1
  KO
K04851  voltage-dependent calcium channel L type alpha-1D
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr04010  MAPK signaling pathway
umr04020  Calcium signaling pathway
umr04022  cGMP-PKG signaling pathway
umr04024  cAMP signaling pathway
umr04218  Cellular senescence
umr04260  Cardiac muscle contraction
umr04261  Adrenergic signaling in cardiomyocytes
umr04270  Vascular smooth muscle contraction
umr04530  Tight junction
umr04713  Circadian entrainment
umr04723  Retrograde endocannabinoid signaling
umr04724  Glutamatergic synapse
umr04725  Cholinergic synapse
umr04726  Serotonergic synapse
umr04727  GABAergic synapse
umr04728  Dopaminergic synapse
umr04911  Insulin secretion
umr04912  GnRH signaling pathway
umr04921  Oxytocin signaling pathway
umr04924  Renin secretion
umr04925  Aldosterone synthesis and secretion
umr04927  Cortisol synthesis and secretion
umr04929  GnRH secretion
umr04930  Type II diabetes mellitus
umr04934  Cushing syndrome
umr04935  Growth hormone synthesis, secretion and action
umr04973  Carbohydrate digestion and absorption
umr05010  Alzheimer disease
umr05020  Prion disease
umr05022  Pathways of neurodegeneration - multiple diseases
umr05031  Amphetamine addiction
umr05207  Chemical carcinogenesis - receptor activation
umr05410  Hypertrophic cardiomyopathy
umr05412  Arrhythmogenic right ventricular cardiomyopathy
umr05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:umr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103674739 (CACNA1D)
   04020 Calcium signaling pathway
    103674739 (CACNA1D)
   04024 cAMP signaling pathway
    103674739 (CACNA1D)
   04022 cGMP-PKG signaling pathway
    103674739 (CACNA1D)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    103674739 (CACNA1D)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    103674739 (CACNA1D)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    103674739 (CACNA1D)
   04929 GnRH secretion
    103674739 (CACNA1D)
   04912 GnRH signaling pathway
    103674739 (CACNA1D)
   04921 Oxytocin signaling pathway
    103674739 (CACNA1D)
   04935 Growth hormone synthesis, secretion and action
    103674739 (CACNA1D)
   04924 Renin secretion
    103674739 (CACNA1D)
   04925 Aldosterone synthesis and secretion
    103674739 (CACNA1D)
   04927 Cortisol synthesis and secretion
    103674739 (CACNA1D)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    103674739 (CACNA1D)
   04261 Adrenergic signaling in cardiomyocytes
    103674739 (CACNA1D)
   04270 Vascular smooth muscle contraction
    103674739 (CACNA1D)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    103674739 (CACNA1D)
  09156 Nervous system
   04724 Glutamatergic synapse
    103674739 (CACNA1D)
   04727 GABAergic synapse
    103674739 (CACNA1D)
   04725 Cholinergic synapse
    103674739 (CACNA1D)
   04728 Dopaminergic synapse
    103674739 (CACNA1D)
   04726 Serotonergic synapse
    103674739 (CACNA1D)
   04723 Retrograde endocannabinoid signaling
    103674739 (CACNA1D)
  09159 Environmental adaptation
   04713 Circadian entrainment
    103674739 (CACNA1D)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    103674739 (CACNA1D)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103674739 (CACNA1D)
   05020 Prion disease
    103674739 (CACNA1D)
   05022 Pathways of neurodegeneration - multiple diseases
    103674739 (CACNA1D)
  09165 Substance dependence
   05031 Amphetamine addiction
    103674739 (CACNA1D)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    103674739 (CACNA1D)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    103674739 (CACNA1D)
   05414 Dilated cardiomyopathy
    103674739 (CACNA1D)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103674739 (CACNA1D)
   04934 Cushing syndrome
    103674739 (CACNA1D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:umr04040]
    103674739 (CACNA1D)
Ion channels [BR:umr04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   103674739 (CACNA1D)
SSDB
Motif
Pfam: Ion_trans CAC1F_C Ca_chan_IQ GPHH PKD_channel
Other DBs
NCBI-GeneID: 103674739
NCBI-ProteinID: XP_040484613
UniProt: A0A8M1FMK5
Position
Unknown
AA seq 2181 aa
MMMMMMMKNMHHQRQQQADHANEANYARGTTLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
CFFADTDILAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEESKRNTSMPTSETESVNTENVS
GGGENQGGCGSLWCWWKRRGTAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV
KSVTFYWLVIVLVFLNTLTISSEHYDQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ
AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV
ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ
ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES
LNTAQKEEAEEKERKKIARKESLENKRNTKPEVNQIANSDNKVTIDDYREEDEDKDPYPP
CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH
KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMAT
FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG
LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI
LYKDGDVDNPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSSGENVGP
VYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL
KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL
NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP
TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML
FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL
CDPESDYNPGEEHTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH
HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS
DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE
VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC
DLQDDEPEETKREEEEDVFKRNGALLGNHVNHVNSDRRDPLQQTNTTHRPLHVQRPSVPP
ASDTERPLFPPAGNSGCHSHHNHNSIGKQAPSSTNANLNNANMSKAAPGKRPSIGNLEHM
SENGHHSSHKHDREPQRRSSIKRTRYYETYIRSDSGDEQCPTICREDPEIHGYFRDSRCL
EEQEYFSGEEGYEDAGSPTWGRQNYSYYSRYPGGSWDFEWPRGYHHPQGFLEDEDSPVCY
DSRRSPRRRLLPPTPTSHRRSSFNFECLRRQSSQEEVPPSPALPHRTALPLHLMQQQIMA
VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYAPLIQVERPDALDQVNGSLPSLH
RSSWYTDEPGISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF
VSATKHEIADACDLTIDEMESAASNLLNGTVHPRANGGVGPVSHRQDYELQDFGPGYSDE
EPDPGRDEEDLADEMICITTL
NT seq 6546 nt   +upstreamnt  +downstreamnt
atgatgatgatgatgatgatgaaaaacatgcaccatcaacggcagcagcaagcggaccac
gcgaacgaggcaaactatgcaagaggcaccacactccctctttctggtgaaggaccaact
tctcagccgaatagctccaagcaaaccgtcctgtcttggcaagctgcaatcgatgctgcc
aggcaggccaaggctgcccaaactatgagcacctctgcacccccacctgtgggatctctc
tcccaaagaaaacgtcagcaatacgccaagagcaaaaaacagggtaactcgtccaacagc
cgacctgcccgcgcccttttctgtttgtcactcaataaccccatccgaagagcctgcatt
agtatagtggaatggaaaccatttgacatatttatattattggctatttttgccaattgt
gtggccttagctatttacatcccattccctgaagatgattctaattcaacaaatcataac
ttggaaaaagtagaatatgccttcctgattatttttacagtcgagacatttttgaagatt
atagcgtatggattattgctacatcctaatgcttatgttaggaatggatggaatttactg
gattttgttatagtaatagtaggattgtttagtgtaattctggaacaattaaccaaagaa
acagaaggcggtaaccactccagtggcaagtcaggaggcttcgatgtcaaagccctccgc
gcctttcgggtgttacgaccacttcgactagtgtcaggagtgcccagtttacaagttgtc
ctgaactccattataaaagccatggttcccctccttcacatagcccttttggtattattt
gtaatcataatctatgctattataggattggaactttttattggaaaaatgcacaaaaca
tgtttttttgctgacacagatatcctagctgaagaggacccagcgccgtgtgcgttctca
gggaatggacgccagtgtgccgccaacggcacggagtgcaggagtggctgggttggccca
aacggaggcatcaccaacttcgataactttgcctttgccatgctcaccgtgtttcagtgc
atcaccatggagggctggacagacgtgctctactgggtaaatgatgcgataggatgggaa
tggccatgggtgtattttgttagtctgatcatccttggctcatttttcgtccttaacctg
gttcttggtgtccttagtggagaattctcaaaggaaagagagaaggctaaagcccgggga
gacttccagaagctccgggagaagcagcagctggaggaggacctaaagggctacttggat
tggatcacccaagctgaagacattgatcctgagaatgaggaagaaggtggagaggaaagc
aaacgaaacaccagcatgcccaccagcgagacggagtcggtgaacacagagaacgtaagt
ggcggaggcgagaaccaaggcggctgtgggagtctctggtgctggtggaaacgaagaggc
acggccaaggctgggccctctgggtgtcggcggtggggccaagccatttccaaatccaag
ctcagccgacgctggcggcgctggaaccgcttcaatcgcagaagatgtcgggctgctgtg
aagtctgtcacgttttactggctggttatcgtcctggtgtttctcaacaccctaaccatt
tcctctgagcattacgaccagcctgactggctgacgcagattcaagatatcgctaacaaa
gtcctcctggctctgttcacctgcgagatgctggtaaaaatgtacagcttgggtctccag
gcgtatttcgtctctctctttaaccggtttgattgcttcgtggtgtgcggtggaattacc
gagaccatcttggtggagctggaaatcatgtctcccctggggatctctgtgtttcggtgt
gtgcgcctcttaaggattttcaaggtgaccaggcactggacttccctgagcaacttagtg
gcctccttgttaaactccatgaagtccatcgcttcgctgttgcttctgctttttctcttc
atcatcatcttttccctgcttgggatgcagctgttcggtggcaagtttaattttgacgaa
acgcagaccaagcggagcacctttgacaatttccctcaagcccttctgacagtattccag
atcctgacaggggaagactggaacgccgtgatgtatgacggcattatggcctacggcggc
ccgtcctcttcggggatgatcgtctgtatctacttcatcatcctcttcatttgtggtaac
tatatcctgctgaatgtcttcttggccatcgctgtagacaatctggctgacgcggaaagt
ttgaataccgcccagaaagaggaagctgaagagaaggagaggaaaaagattgccagaaaa
gagagcctggagaataaaaggaacacgaaaccagaagtcaaccagatagccaacagcgac
aataaggttacaattgatgactatcgagaagaggatgaagacaaggacccctaccctcct
tgtgatgtgccagtaggggaagaggaagaggaggaggaagaggacgaacctgaggttcct
gctggcccccgtcctcgcagaatctcagagttgaacatgaaggagaaaatcgcccctatt
cctgaagggagtgcgttcttcattctgagcaagaccaacccgatccgcgtgggctgccac
aagctcatcaaccaccacatcttcaccaacctcatcctcgtcttcatcatgctgagtagc
gccgcccttgccgccgaggaccccatccgcagccactccttccggaacactatactgggt
tactttgactatgctttcacagccatctttactgttgaaatcctgttaaagatggcgacg
tttggagctttcctccacaaaggggctttctgcaggaattacttcaatctgctggatatg
ctggttgttggggtgtccctggtatcatttgggatccaatccagtgccatctccgttgtc
aagattctgagggtcttaagggtcctgcggccactcagggcgatcaacagagcgaaagga
cttaagcacgtggtccagtgcgtcttcgtggccatccggaccatcggcaacatcatgatc
gtcaccacccttctccagttcatgttcgcctgcatcggggtccagttgttcaagggaaag
ttctatcgctgtacagacgaagccaaaagtaaccccgaagagtgcagggggcttttcatc
ctctacaaggatggggatgttgataaccctgtggtccgtgagaggatctggcaaaatagc
gatttcaacttcgacaacgtcctgtctgctatgatggcgctgttcacggtctccacgttt
gagggctggcctgcgttgctgtataaagccatcgactcgagcggagagaacgtgggccct
gtctacaactaccgagtggagatctccatcttcttcatcatctacatcatcatcgtggct
ttcttcatgatgaacatctttgtgggctttgtcatcgtcacgtttcaggagcagggagag
aaagagtataagaactgtgagctggacaaaaatcagcgccagtgtgttgaatacgccttg
aaagcacgtcccctgcggagatacattcccaaaaacccctaccagtacaagttctggtac
gtggtgaactcctcgcctttcgaatacatgatgtttgtcctcatcatgctcaacacactc
tgcttggccatgcagcactacgagcagtccaagatgttcaacgacgccatggacattctg
aacatggtcttcactggggtgttcaccgtcgagatggttttgaaagtcatcgcgttcaaa
cctaaggggtattttagtgacgcctggaacacgtttgactccctcatcgtaatcggcagc
attatagacgtggccctcagcgaagccgacccaactgaaagtgaaaatgtccctgtccca
actgccacacccgggaactctgaagagagcaatagaatctccatcacctttttccgtctt
ttccgagtgatgcggttggtgaagcttctcagcaggggggaaggcatccggacattgctg
tggacttttataaagtcctttcaggcactgccctatgttgccctcctcatagccatgctg
ttcttcatctatgcggtgattggcatgcagatgtttgggaaggttgctatgagagataac
aaccagatcaacaggaacaacaatttccagacctttccccaggcggtgctgctgctcttc
aggtgtgccacgggcgaagcctggcaggagatcatgctggcctgcctgccggggaagctc
tgcgaccccgagtcggactacaaccccggggaggagcacacgtgtgggagcaacttcgcc
attgtttatttcatcagtttctacatgctctgcgcgtttctgatcatcaacctgtttgtg
gctgtcatcatggacaactttgattatctgacccgggactggtctattctggggcctcac
catttagatgaattcaaaagaatatggtcggaatacgaccctgaggcaaaaggaaggatc
aagcacctcgatgtggtcactctgctccgccgcatccagcctcccctggggtttgggaaa
ttatgcccacacagagtagcctgtaagagactcgtggccatgaacatgcctctcaacagc
gatgggacggtcatgtttaatgcaaccctgtttgctttggttcgaacagctcttaaaatc
aagacggaagggaacctggaacaagctaatgaagaactccgagctgtgatcaagaaaatc
tggaagaaaaccagcatgaagctgcttgaccaagttgtccctccagccggtgatgatgag
gtaaccgtggggaagttctatgccactttcctgatacaggactactttaggaaattcaag
aaacggaaagaacaaggcctggtgggaaaataccctgcgaagaacaccaccattgcccta
caggcaggattaaggacactgcatgacattgggccagaaatccggcgtgctatatcatgt
gatttgcaagatgacgagccggaggaaacaaaacgagaagaagaagaagatgtattcaaa
agaaatggtgccctgcttggaaaccatgtcaatcatgttaatagtgataggagagacccc
cttcagcagaccaataccacccaccgtcccctgcatgtccaaaggccttcagttccacct
gcaagtgatactgagagaccgctgtttcctccagcaggaaattcggggtgtcatagccat
cataaccataattccataggaaagcaagctcccagctcaacaaatgccaatctcaataat
gccaatatgtccaaagctgcccctggaaagcggcccagcattgggaaccttgagcatatg
tctgaaaatgggcatcactcctcccacaagcacgaccgggagcctcaaagaaggtccagt
attaaaagaacccgctattatgaaacttacattagatctgactcgggggacgagcagtgc
cccaccatctgccgggaagatccagagatccatggctacttcagggactcccgctgcttg
gaggagcaggaatatttcagtggcgaggagggctatgaggatgccggctcaccgacctgg
ggcaggcaaaactacagctactacagccgatacccaggcggcagctgggacttcgagtgg
ccccgaggctaccatcacccccaaggcttcttggaggatgaggactcgcccgtttgctat
gattcccggagatctccaaggagacgcctactacctcccaccccgacatcccaccggaga
tcctccttcaacttcgagtgcctgcggcggcagagcagccaggaggaggtcccgccgtcc
cctgccctcccccaccgcacagccctgcctctgcacctgatgcagcaacagatcatggca
gttgcgggcctggattccagtaaagcccagaagtactcgccgagccactcgacccggtca
tgggccacccctccggcgacccctccgtaccgggactggacgccatgctacgcacccctg
atccaggtggagcggccggatgccctggaccaggtcaacggcagcctgccatccctgcac
cggagctcatggtacacggacgagcccggcatctcgtaccgaacgttcacaccagccagc
ctgactgtccccagcagcttccgcaacaagaacagtgacaagcagaggagcgcagacagc
ttggtggaggcggtcctgatatctgaaggcttaggacggtatgcaagggaccccaaattt
gtgtcggcaacaaaacacgaaatcgccgatgcttgtgacctgaccatcgacgagatggaa
agtgcagccagcaacctgctcaacgggaccgtgcatccgcgggctaacgggggcgtgggc
cccgtctcccatcggcaggactatgagctccaggacttcgggccgggctacagcgatgaa
gagcccgaccccggaagagatgaggaggacctggcagacgaaatgatctgcatcaccacc
ctgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (35)   
   KEGG PATHWAY (35)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (5)   
   Pfam (5)   
All databases (54)   

Download RDF
DBGET integrated database retrieval system