ID   36011_ASFK5             Reviewed;         353 AA.
AC   P0C9P7;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   08-NOV-2023, entry version 33.
DE   RecName: Full=Protein MGF 360-11L;
GN   OrderedLocusNames=Ken-034;
OS   African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus; African swine fever virus.
OX   NCBI_TaxID=561445;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages. In addition, inhibits the
CC       phosphorylation of host TBK1 and IRF7 and thereby negatively regulates
CC       the host cGAS signaling pathway and antagonizes IFN-mediated antiviral
CC       activity. {ECO:0000250|UniProtKB:P0C9P6}.
CC   -!- SUBUNIT: Interacts with host TBK1 ad IRF7.
CC       {ECO:0000250|UniProtKB:P0C9P6}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 360 family. {ECO:0000305}.
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DR   EMBL; AY261360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C9P7; -.
DR   Proteomes; UP000000861; Genome.
DR   GO; GO:0039722; P:suppression by virus of host toll-like receptor signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0039557; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039723; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity; IEA:UniProtKB-KW.
DR   GO; GO:0042330; P:taxis; IEA:InterPro.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR002595; ASFV_MGF360.
DR   Pfam; PF13606; Ank_3; 1.
DR   Pfam; PF01671; ASFV_360; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host IRF7 by virus; Inhibition of host RLR pathway by virus;
KW   Inhibition of host TBK1 by virus; Inhibition of host TLR pathway by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..353
FT                   /note="Protein MGF 360-11L"
FT                   /id="PRO_0000373277"
FT   REPEAT          59..88
FT                   /note="ANK"
SQ   SEQUENCE   353 AA;  41776 MW;  F469BC8CD3137C2A CRC64;
     MLPSLQSLSK KVLAKQCIPV DQYHILKCCG LWWYDGPITF YTYRNKMFIK STCFSEGIEL
     NTVLMKAAKE NNHDLIRLFV EWGADINYGL VCAHSEHTRN LCRELGAKDR LDREYILKIF
     FDTTRNKTDS NIILCHEMFS NNPNLKHVDD LDLREEIMWE LRGLMEITYM LDHDNSFSNM
     LTKYWYAIAV DYGLKKAIHY FYQKYTHLHR WRLMCALFYN NVFDLHELYE IERVRMDIDE
     MMHIACIQDY SYSAIYYCFI MGANINQAMF VSIQNYNLGN MFFCIDLGAN AFEEGKTLAI
     QKENYLIADA LSLKHYNPVI SLLSAVTDPE KINSMLKNYH SKNMVVFLDY ERR
//