ID   A0A011MXY3_9PROT        Unreviewed;       352 AA.
AC   A0A011MXY3;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN   ORFNames=AW08_01982 {ECO:0000313|EMBL:EXI67426.1};
OS   Candidatus Accumulibacter adjunctus.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Candidatus Accumulibacter.
OX   NCBI_TaxID=1454001 {ECO:0000313|EMBL:EXI67426.1, ECO:0000313|Proteomes:UP000020218};
RN   [1] {ECO:0000313|EMBL:EXI67426.1, ECO:0000313|Proteomes:UP000020218}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK-12 {ECO:0000313|Proteomes:UP000020218};
RA   Skennerton C.T., Barr J.J., Slater F.R., Bond P.L., Tyson G.W.;
RT   "Expanding our view of genomic diversity in Candidatus Accumulibacter
RT   clades.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EXI67426.1}.
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DR   EMBL; JFAX01000010; EXI67426.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A011MXY3; -.
DR   STRING; 1454001.AW08_01982; -.
DR   PATRIC; fig|1454001.3.peg.2022; -.
DR   Proteomes; UP000020218; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000020218};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          4..121
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF13676"
FT   REGION          181..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   352 AA;  36244 MW;  73237DE7F528EB41 CRC64;
     MADIFLSYAT EDRETAAAVA GRFEALGFSV WWDRKIPAGM TWRQVIESAL NDMGCMVVLW
     SGSSLASTWV SEEAEEARMR GKLVPALIEA VLPPLGFRGI QAADLIDWDG SGEAAGFRHL
     LAGVEGFLPG RSAAGRPVVP AADTRVSAGR RRGRWMAGAG ACLLLVLTAG TWFWYGQHEP
     PAASATRSDG VQGPAAAAPT AAGKPSLATA ATRSQPGEGG VASTSAPKPE QPGPVASTST
     AGRGSPEDAA PAASTTPARD GKAATTASVR PGATAATGNE ANPGLDPPPP RPRETTILTS
     APASAGRPAR PAAEPGARPA RAGRCTDLLE RQSLGDALSA DERAYFQKEC RR
//