ID A0A016RRA6_9BILA Unreviewed; 612 AA.
AC A0A016RRA6;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0000256|ARBA:ARBA00031556};
GN Name=Acey_s0396.g669 {ECO:0000313|EMBL:EYB80935.1};
GN Synonyms=Acey-brc-1 {ECO:0000313|EMBL:EYB80935.1};
GN ORFNames=Y032_0396g669 {ECO:0000313|EMBL:EYB80935.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB80935.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB80935.1}.
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DR EMBL; JARK01001732; EYB80935.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016RRA6; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 27..67
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 426..487
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 504..604
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 139..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 69071 MW; D75BBB28B7ABE922 CRC64;
MSACQSSYEA ALKINNVLTK IQSELKCGVC RSTFSNPVVA TCAHTFCKDC LNQVFQLRRC
IECPLCRKDI KKRSCTPSEQ QDALVKGYLQ LGRIFREDIQ NQSFSIPKDI AYMESQVPAV
TEPTNIPIRD FRPEPQFALP KARARRKQPL SNHASSKVSR MDPISEESEC KENTPLQKTT
KAQDNEANIL ARRTGDDLVR YARSKSVEVQ CDLPDPACVC RDLHTSLRSF MGRSIDTSYP
SDLHALFAMM PECRKLLEEN ISTLYQLLPP PPCAHDDVGD CRLPLKAEMV DFELKDVKEG
REGLPDDVHC DELMETQPSP LIAEGMPPSV KKDDEKDDEA SPSHSRPLSD VVPQSPQGSN
DDMEITLHAN FESFPEELTP TRCEAKTTRN ANKESCSMVI SISRPSCIED ENLVCEFLSL
FRTVGFNQEI TSTTTHLVMM NCRERTCQRR SLRYVYAIAY KCELLNRRWL EECVQSKSLL
PTTQYTLTCE SSSDTPAWLL SKSSKTPLFD KMKFYLPKSF SDSQLLPRQK LIELITICGG
GCYDKPWELD GAQRAYTIFM PRSCESDAAR RYEASMNNVP VLVADWVLDS IAEYRLLPID
SYKVGRGGPS SG
//
