ID A0A016S903_9BILA Unreviewed; 535 AA.
AC A0A016S903;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN Name=Acey_s0273.g971 {ECO:0000313|EMBL:EYB86754.1};
GN Synonyms=Acey-apc-2 {ECO:0000313|EMBL:EYB86754.1};
GN ORFNames=Y032_0273g971 {ECO:0000313|EMBL:EYB86754.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB86754.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB86754.1}.
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DR EMBL; JARK01001609; EYB86754.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016S903; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044554; APC2-like.
DR InterPro; IPR014786; APC2_C.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01013; APC2; 1.
DR SMART; SM00182; CULLIN; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 215..403
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 535 AA; 61142 MW; DBD3D184E9A4E869 CRC64;
MQIYEVLWTW LSAVPLPDQA DLKQISDWGK DFLRKTIIDR LTGSIYDMAV VNFPKSYPTL
STLRNCMINV QEYGREKLVN TLIDDVEAQL LHIAVDTPTI LNGYSLCVES LRELDPSCVI
MHRVCKVIKE YLKRRPDTVR QIINYITSEK RDDLAAHLAN RCGTIVDEDE LTGANDDFLP
EAMNLSQWRH WMPDPIDASP GESGRFRQAA DVFNMLVSVY GSKEMFVKEY RQLLAERLTS
SNTKDPIFER RYLDLLKLRF NEGELQQCEV MLKDIRDSQK IDRTALGRKC IPVSACVISS
HFWPKIVSET VSEFPPALEE ALTEYEKSFM DHKESRKLQW MRAVGCVEVT LKLGDVEVDK
VVPNPIAAVL YLYLEKESWT IAEVAERLSI SKGVARRRLE WWRTQGLLTQ NLPAGATAEE
WALVTNPSLL ATSRGAADDE SDEDEGAIEE TADAIDALEQ YWSYTKNFIA NHDNGEVKAE
RMHRIYRMFS SPSAQGPSLE TVTAFLMRKV KLNLLTYNNG FFRVVKESAT KGNER
//
