ID A0A016SDT7_9BILA Unreviewed; 897 AA.
AC A0A016SDT7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=protein xylosyltransferase {ECO:0000256|ARBA:ARBA00011972};
DE EC=2.4.2.26 {ECO:0000256|ARBA:ARBA00011972};
DE AltName: Full=Peptide O-xylosyltransferase {ECO:0000256|ARBA:ARBA00042865};
GN Name=Acey_s0240.g3345 {ECO:0000313|EMBL:EYB88863.1};
GN Synonyms=Acey-sqv-6 {ECO:0000313|EMBL:EYB88863.1};
GN ORFNames=Y032_0240g3345 {ECO:0000313|EMBL:EYB88863.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB88863.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-
CC L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:50192, Rhea:RHEA-
CC COMP:9863, Rhea:RHEA-COMP:12567, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132085; EC=2.4.2.26;
CC Evidence={ECO:0000256|ARBA:ARBA00001814};
CC -!- PATHWAY: Glycan metabolism; chondroitin sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004840}.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 14 family. XylT
CC subfamily. {ECO:0000256|ARBA:ARBA00010195}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB88863.1}.
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DR EMBL; JARK01001576; EYB88863.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016SDT7; -.
DR STRING; 53326.A0A016SDT7; -.
DR UniPathway; UPA00755; -.
DR UniPathway; UPA00756; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030158; F:protein xylosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030206; P:chondroitin sulfate biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR003406; Glyco_trans_14.
DR InterPro; IPR002889; WSC_carb-bd.
DR InterPro; IPR043538; XYLT.
DR PANTHER; PTHR46025; XYLOSYLTRANSFERASE OXT; 1.
DR PANTHER; PTHR46025:SF3; XYLOSYLTRANSFERASE OXT; 1.
DR Pfam; PF02485; Branch; 1.
DR Pfam; PF01822; WSC; 1.
DR SMART; SM00321; WSC; 1.
DR PROSITE; PS51212; WSC; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 201..294
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
SQ SEQUENCE 897 AA; 102875 MW; E645401497612896 CRC64;
MRKRSTPALR TAAPAAIAPH RIPVLRTMYI VAATLLFFFL NLYFIYVYVQ NYSKDELVRS
FEKSHLSQSK EDSQHIRSTP GINFHSCDIS DQLALSALSR AKTESCRRKL QHEGFGRCRP
HITQLLVLFR SMIVPRVYVN CPSSRIDQRN EYRPAVKWQL LVCTVHWNRE EISDAACKLK
NGLFHDSFPE SQCVNHDRLL INFRVGCFED SKSNRALNGF AYEFKSDNSM EKCRATCYRA
GFIYYGLEFG RECFCGDSLA KQSIDEARCT EYRCTGNSSQ YCGGFNAVEI FRTGLKEPHL
MPKAKYVETA DADVNTKRPR ILFLLQLNGR NERQVKRLLK ALYSPHHYYY IHVDQRQLYM
LTEVKAVAAK LSNVYVAPDP HSTIWGGASL LTMVQDAIRR SIAMPSLSDW DYLINLSESD
FPVLTLNELE TQLRMNPGQS YMSSHGYNTA RFIQKQGFDF VFIECENRMW RIGKRDEFPR
NLRIDGGSDW IILHREFAEY SISDDELPRK MRALFGSIIL PVESFFHTLS YNSHFCNSIL
GSNLRLTNWN RKQGCRCESL KKVVDWCGCS PLVFKKEHTH KFAIKNAQAK PFYIARKFES
LIDIDAIALA EKQAMRDRPH LLHTDDVMFN VTFVNHYKAD IDGYSLPFSM MAESLLSMYD
KDAEFVSLLR IDAVKVHSSA PHQIIFTMQI RQSDVPLQLL VQRRLVSHIV SPAIVDGFKL
ESVMAGTEID HKEEIFRGFT AYADVTSSPV VLLRWSRVTG MATTVNETKT SPPIRYLWRG
PKEKLVATQK LRSYDSMYGG QFAALQLKNL NTSNLEAGMW SVVIQTDRGE SPETIATVWL
PIYSTDDKPL FQSLVGNFFI IQDSCSKTCF STTWSTFHPD PKSDILVGYD KTVEALV
//
