ID   A0A016SG98_9BILA        Unreviewed;      1456 AA.
AC   A0A016SG98;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=BPTI/Kunitz inhibitor domain-containing protein {ECO:0000259|PROSITE:PS50279};
GN   Name=Acey_s0232.g3024 {ECO:0000313|EMBL:EYB89376.1};
GN   ORFNames=Y032_0232g3024 {ECO:0000313|EMBL:EYB89376.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB89376.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYB89376.1}.
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DR   EMBL; JARK01001568; EYB89376.1; -; Genomic_DNA.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00109; Kunitz-type; 2.
DR   CDD; cd22593; Kunitz_conkunitzin; 1.
DR   Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 4.
DR   InterPro; IPR006150; Cys_repeat_1.
DR   InterPro; IPR006149; EB_dom.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR028150; Lustrin_cystein.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   PANTHER; PTHR46339:SF5; PROTEIN CBG13983; 1.
DR   PANTHER; PTHR46339; PROTEIN CBG15282-RELATED; 1.
DR   Pfam; PF01683; EB; 3.
DR   Pfam; PF00014; Kunitz_BPTI; 4.
DR   Pfam; PF14625; Lustrin_cystein; 13.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 4.
DR   SMART; SM00289; WR1; 15.
DR   SUPFAM; SSF57362; BPTI-like; 4.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 2.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 4.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          380..416
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   DOMAIN          464..514
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   DOMAIN          571..623
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   DOMAIN          677..732
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   REGION          1285..1305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1456 AA;  157592 MW;  64990D74184D6A24 CRC64;
     MRWCSLDDAC DTCTIRTPLG AKCDGENGKF LFQFCNPRTK KIDVESSSYL ICSEGTYRQR
     QCSDDGRTHF SATTLECVDP ATLTFHAQGT SGSGRVGDVC TFNTDCLSGM YCAIGQCRCL
     STYIAVDAYC YERISPSESG CFYDVQCSAV WPDAYCKNGQ CQCPSQDMVA VKTRDGTLCL
     WSSPTEPSCP LPSLPPPDSA AALVVLPAPS AKNTVSIATC NPHASSIPAT EELLLTKAHE
     HKCAVRGSVD DTTPKDVSDL YDCIDNSKFW QGQGLDTNSH PVGVCCMNRA CPRGNPAYIA
     TRTDLGQIPQ GGCTITQPCA DPFECTEVAS QSLCCPSRKS ICSESGGRSK NPLRSTPYDA
     GMRFDQLTGE QANYAVGIST RYYYNPIDGQ CHPFTYNGFL GNFNNFHTQS DCQIFCARLQ
     CTHGNPLTTG HGVPQRCQRD ADCPSTHTCA AEHAVCCPTP QTLCTEPLRV GDCKQSVRQF
     WYNAETRTCE GFLYTGCQGN NNRFHTLNEC QSYCKNINAE PKCPQGRAYV EYTGKFLQCG
     DGLGGNPCPA NYECHFDGHV HGCCPSKAYT CSLQLSKGVA CGSGSSYRYY YNNQLKECQS
     FLFLGCDGNS NNFPTDEKCQ SYCEIAVCPN GGSPLRSNSK LRSCATTDPC PVGYECSQVD
     GNGVTHRRCC PTKASICAKP PQMGMLPKCG SGSGQTRFYF NVALQTCSPY TSNGCDSSLN
     SFKTLMECED FCLSAGCKPG DTVYKDPNTN RPFLCNTALQ NNCPTNYQCT LNSLTQEHVC
     CGSDSMGVCP AGEKAFVDPM SSTPRQCAMA ADGKCPAGYL CRFSQNNHKY YCCGSISGSL
     CPAGRALFRY AATQLPLQCS IAHGGGACPP SYSCQSDVPG AFQGYCCSQH PVCPGGVDFH
     VDEKSQMPTT CTSEGFALCP NGYTCQQQPE TINFYCCAGR DKEGINDGCP PSQYAYVADG
     QVKSCDPFNV DATTCPSEYT CQWSITNQKY QCCGTRPIRQ LKPNKIDDGC PRKQFALLDR
     RNNQPRVCTA GEEKSCPTGF FCQFSAKRGQ FQCCGQSGGC PSRRAAFIAI DGNAQECLPG
     PDMCADGYEC VLSAYGNGKN ICCSKEENEC AENEKMIGGK CVVQVKIGGA CHKDAECGGG
     SKCIAHSCTC ASDQDAVNDE CVARACESNQ IILEGKCVDR AAFGESCKSS LQCVSNMRCL
     SGRCDCGKGE KAEGNNCVKI SEESKKSRPK NNDVCPNESE HAFFERGTTR MRYCSQIADD
     CPKGYSCQYS DLVKQNICCG EGDGDEEKKP KLGKPKGSTA SNPGHCPSGM TPYLLNGKPK
     SCSSGTCPYG FECKFSSSKK NYYCCSKVMK KTNHLRRDGG CERGAVLLYP ATQEPVHCDL
     KTRGCPNGYL CLPHTATKVL QCCSVQSDKD SSRSMNLEIE CPSYMVRVIG QRHGRRASYC
     ARSCPPGQTA VNGVCQ
//