ID A0A016SKP8_9BILA Unreviewed; 893 AA.
AC A0A016SKP8;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN Name=Acey_s0212.g2233 {ECO:0000313|EMBL:EYB90916.1};
GN ORFNames=Y032_0212g2233 {ECO:0000313|EMBL:EYB90916.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB90916.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB90916.1}.
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DR EMBL; JARK01001548; EYB90916.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016SKP8; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33332; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR33332:SF54; REVERSE TRANSCRIPTASE, PUTATIVE-RELATED; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR Pfam; PF00078; RVT_1; 1.
DR PRINTS; PR01345; CERVTRCPTASE.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 707..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..324
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 57..84
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..765
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 100223 MW; FAC85B5DE0C26F1B CRC64;
MDTPQAPVAP QTRRGKKHRI DFDSPHEKDQ NDFDRAVDLI VRDQTLPPHL KTAIGFMLEM
KEQMNAVMTR NQELVEENRK VNEKNSIKES SAPLSTARVI QDINCVRHLL DFLEEHDIIS
SNQHGFQKGK STVTAMVKVL NDWTKYLDEG KSVDVVYFDF CKAFDKVSHS KLIHKMQLVG
IHPRIVSWIK AFLTDRTYSV RVNSVLSFPR PACSGVPQGG VLSPILFNIY TFDLLSALSD
RGIQFSAFAD DVKLYRPIVT ENDRSALQEA VDFVHSWSCG WGLPLSMDKC KVLHLGSRNK
CDSYTIDNTR LEEPCQVTDL GFIITKDLSF DTHCQMIALK ASKAIYNLFR AFSTTNSYLY
LQAYKLYIRP ILEYGTPVFS PHKQSIINKL ESVQNSFTRK LMMRALGLAY DQIPCSWVRN
ENLGLPTLLQ HCFVEDVGTM NNCTRVIGDV KFDELSSETW QRVITVEGTL HIENTDIESL
DAMKDLQIVG LMTPALVISK NKKLVDIAAL MSMNITSEEP VLEFKDNPVV CHNIVERRAL
DKWTTEKGIY VKFAENCLKS CPGGVVTSEY LANLDKRCNF IKGNLIIDKI KDLPTNMNKL
EQVEKIYGRL FITNNEAVED LRFLRNLKDI INSGHERPAL VIENNKNLIN TTLESLKRVR
EGEWKETTRW HLEDILTWDP DSYGGEGEVS IEGIYGRPTG TKAEDDYPLL LGLAAFIVFL
VAIAAAIGIL TTIKLRKKAC GPSSRRKKER TPKAMGKKRT FFKQRGRLNK GTPTEKSKTP
TPAKQSGRPT KGTPTGKSKT PTPAQQSGRL NKGTPTAEQS KTPTPAKQSG RLNKGTPAGK
SKAPTPAQQS GRQNKGTPTA ASRTPTPLKE SKRPQKAAPH LKNKKPVAAG QHR
//
