ID A0A016T5D0_9BILA Unreviewed; 1050 AA.
AC A0A016T5D0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=Acey_s0136.g1956 {ECO:0000313|EMBL:EYB97841.1};
GN ORFNames=Y032_0136g1956 {ECO:0000313|EMBL:EYB97841.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB97841.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB97841.1}.
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DR EMBL; JARK01001472; EYB97841.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016T5D0; -.
DR STRING; 53326.A0A016T5D0; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd06362; PBP1_mGluR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF158; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1050
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001490429"
FT TRANSMEM 632..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 823..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 633..852
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 1050 AA; 118078 MW; 839EE6490F271C7C CRC64;
MLFQTIFLCC LMFSILALAT HILANVTEAA KMVDGSDLAP SNKVRQIRIA GDLMLGGVFP
VHTKSQNPDE PCGEIAETRG VHRVEAMLYA LDQINAQKDF LRGYKLGALI LDSCSNPAYA
LNQSLEFVRD MIGSSDASDY VCSDGSDPRT RSINKKKNVV AVVGASYSSV TVQIANLLRL
FRIVQVSPAS TNADLSDKSR FEYFARTVPS DDYQAMAMVE IAVRFKWTYV SLVYSADEYG
ELGADAFKKE ARKKGICIAI EERIQNKKES FVESIDNLVK KLQPDKKVGA RVVVLFVGTE
YVPELLKHTA ERMKLSAGYS KKKIIWLASE SWDRNNEKYM IGHNRLAAQG ALVLMLASQK
VPSFDEYLLS LHPGSEKFER NKWLRELWIS KYKCSFDLPP ESTENRCEDA RQTGDNFHAD
DKVQFVIDAV YAIAHALQAM KSKVCPDDAI ETSWISRYSK KPDICHAMQN IDGDEFYQKY
LLKVQFQDIV GKNFRFSPQG DGPASYTILT YKPKSLDKKR RVADDDASDG SDYVEIGHWS
ENNLTIYEDE LWWGADQVPF SQCSLECRTG YRKQLIKDEQ CCWACSKCDD YEFLINETHC
VACELGWWPT EDRKGCYDMS IAHLKHMRWS SLYSIVPAIF AVIGIIATLF VIVIYIIYNE
TPVVKASGRE LSYLLLISMI MCYAMTFVLL SRPNTIVCAI KRTGIGFAFS CLYAAMLVKT
NRIARIFSQA SLSAQRPLFI SPLSQVVMTS MLAGVQLIGS LIWLFVVPPG SRHDYPTRDQ
VVLTCNVPDH HFLYSLAYDG ILIIACTVYA VKTRKVPENF NETKFIGFSM YTTCVVWLSW
IFFFFGTGSD FQNLSLIDEP LPRKAKVKQA VETGSFGKAR QDTSNLGNSA LSVTGNVPKH
VSPITTGETY LILEACQVAR LVKQAVHTYV FGCPRNNGQS LVVKFDPNYL VMHFHLDVSK
CRVGLHIFAK VVDHTVREAQ KRPETRRRKH AEQAVSSLLL DEFPERSTAV LPGPNSRKKV
LTNRSSGGLQ CASGCFYRQL LSPTRATCMS
//
