ID A0A016T6K4_9BILA Unreviewed; 559 AA.
AC A0A016T6K4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=TFIIS N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51319};
GN Name=Acey_s0132.g1708 {ECO:0000313|EMBL:EYB98307.1};
GN Synonyms=Acey-F13B12.1 {ECO:0000313|EMBL:EYB98307.1};
GN ORFNames=Y032_0132g1708 {ECO:0000313|EMBL:EYB98307.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB98307.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family.
CC {ECO:0000256|ARBA:ARBA00037992}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB98307.1}.
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DR EMBL; JARK01001468; EYB98307.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016T6K4; -.
DR STRING; 53326.A0A016T6K4; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 365..443
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 1..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..250
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 62198 MW; 946672E8E79C684A CRC64;
MADYGSPGEV ADNTAHEANG ASPDYQSASS PRRSPDGSPH DDDYERAQSP GPDSPIGTPS
HVSGPSSPVS AHGDDSGDEF RADSPNVPGS PEAEDGDQPG EYRPNSPLQD FPSSSRSPQQ
AEGSAPQSPR YQEDDGDEKS EVDAARAGSD GDDDSSKKRG AAGSDDDDDE EVSRKRRRVV
NSDDSDNEET GSRKNLLDSD DSDDDMDEEQ RKKKLGNLMV NIFGEDVDED ADASREAEGD
EGEEEDDRAQ TGHDEEGYED DYGDRHKGDV DNAGFEWDFD VMLREKKAER RKKRRKRDTG
IDIINDDDGI IAHMVSAMKT AAKDDRHSNT ERKPALKKRK MLSDVKMMLL RMDMLEAMID
GGMMSAVSEW LAPLPDKSLP ALEIRTELLK ILQGFGRLDQ GVLKQSGLGR AVMLLYKHPR
ETKENKAMAA HIIREWSRPI FQLDTDFRSV SREERVQRDL DHMSSVKKRR MSGEAGPSEQ
SSTPKEPEKV INRARVPRPS TKDYVVRPKS NVEGEFKGER KGRAFARLDK AQRDFMERTK
RMKVKRAVGV SLEGRNMAL
//
