ID A0A016TDP0_9BILA Unreviewed; 1009 AA.
AC A0A016TDP0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=RhoGAP domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0112.g271 {ECO:0000313|EMBL:EYC00812.1};
GN Synonyms=Acey-srgp-1 {ECO:0000313|EMBL:EYC00812.1};
GN ORFNames=Y032_0112g271 {ECO:0000313|EMBL:EYC00812.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC00812.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC00812.1}.
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DR EMBL; JARK01001448; EYC00812.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016TDP0; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07656; F-BAR_srGAP; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14166:SF17; RHO-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 28..308
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 481..669
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 454..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 171..198
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 454..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1009 AA; 113700 MW; 51C701E4E8C182AF CRC64;
MASTNDTKKL SSAKQEKAIM HDFEVHVKEI RAQLNEQIRC IGERTETQIA VLQEVDDFFR
KRGEAEAEYS RQLEKLAKGI MQRHKAEKNR RDSWTQHAAC SAWQQLVDDT KCEALQRQAL
AELYSKHITA SISSRCEDLG KISKRCREIG ALSHSEINRV LTELHTAMKT YQLCYSELAA
VERKLRIAEE EKRRYEEANP GKTEGTRKYR NLCKYLKKRE DKYEAVHSKC TKGRNEYLMC
IRAANAALHR FFAEDLSYLI DCTDLGMDYW TKALLGQVVE VRKRITQREM DGLAELGTLR
SAIDAKADKQ RFFEAHHATF MLPKQFEFRP QLGDCVCTVS AEKGIAAELA QRQKQIEKRL
EGLRFESDEV WKSLEASDRQ LLQMYNSDFK EKEEPGKWRQ DILVTYQYYL KKFEYFLLNG
NLIERLEARS KAISDALSRA SGVTANNNMI VGTEERTRRR PKRIGAAGTD DSKPRPKLFG
GSLDEYVEAT GEPIPLVVVS AIGYLSRYSL RNQGLFRVSG SQSEINRFKE AYERGDDAFA
DLTDGSESNS VAGVLKLYLR ELREPLFPIF LFDQFTDCAK ADSPQEFVRR ARELIEKLPV
SHILLLRFLF AFLSHLCEFA DENMMEPHNM AICFGPTLLP IPEGKDQVFY HNFVNELVRN
LILNVNEVFP QDLPGPAYDK YAAVADDVDH MGYMDEVDGL SEDEDCMRNG VGGGMSADSA
LAESTYDMST STDIVRDATS STLQRPPTPE EALSQPPSVS SRSSNRSNLN LEAYLRRMSE
DVSPALRTEM PHLIANEVAA KFAARERAAT APKSSSRQTP IWEQERPSSH ASHTSTAPSY
ASYSSQQSTS GGQTQSVNTS TTTVHASNNA VGPISGVRLP TMTSLRDQLH HFRKELNSGR
EDNSRVYPMS EGLSGFPRRV AQHDGTVLDA RGGSEAPRHL DRCFGDARSA IGERGSEPAL
MKTDQPDVVA SARHSVRAQS ELQKLRDREN SSPPLEELAA AALKASQFD
//
