ID A0A016TME7_9BILA Unreviewed; 468 AA.
AC A0A016TME7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Peptidase A2 domain-containing protein {ECO:0000259|PROSITE:PS50175};
GN Name=Acey_s0091.g2450 {ECO:0000313|EMBL:EYC03837.1};
GN ORFNames=Y032_0091g2450 {ECO:0000313|EMBL:EYC03837.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC03837.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC03837.1}.
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DR EMBL; JARK01001427; EYC03837.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016TME7; -.
DR STRING; 53326.A0A016TME7; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05483; retropepsin_like_bacteria; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR034122; Retropepsin-like_bacterial.
DR PANTHER; PTHR22955; RETROTRANSPOSON; 1.
DR PANTHER; PTHR22955:SF69; RNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF13975; gag-asp_proteas; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 135..249
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT REGION 49..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 468 AA; 53263 MW; 667D2568C440DF77 CRC64;
MRRKALREQN RCWKCFSRDH NSFVCQKRDC TLCGQKHHIS LCLKKDQPQR NYSNKRGTRD
IVPFRPAQRD PRNRGLKSNN NQSDRKEHTS TNVQVCMGTL AKPNLRVEST LSEQLVLMTA
EGSIWNARRQ QYEKILFLFD SGAQKTAVDE ELAEQFGLPR QMTENCTMSG IGGRVETFES
HIVPLKIGSA FGEEIEITVQ TRPVITEGFP SVRLEQGDVA FLKANEIFLA NTKLRGEQQI
PRVLVGLDYY HDLVTYTGAK TPSGLHLAKT VFGHTIYGRG LSSVPQPNSV SYNLTAICEK
TEHQVLHEHS RLEGPMQRKR AENCSKYSDE IVHAYGFTST SLPLKGAATD IAKNYSVATG
RLQSPQLQPS ALNASRRRPA LHAKPPSTPS VRRSYPTSAI RRHLPRPRAA LRHLPRQEVD
RRITRRKKAK TNDTVYAYSC RSPEYHRRID DPHRIPNHYP YCTQSHNS
//
