ID A0A016U648_9BILA Unreviewed; 1113 AA.
AC A0A016U648;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=FYVE zinc finger {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0054.g2466 {ECO:0000313|EMBL:EYC10625.1};
GN Synonyms=Acey-F22G12.4 {ECO:0000313|EMBL:EYC10625.1};
GN ORFNames=Y032_0054g2466 {ECO:0000313|EMBL:EYC10625.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC10625.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC10625.1}.
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DR EMBL; JARK01001390; EYC10625.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016U648; -.
DR SMR; A0A016U648; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd18501; BACK_ANKFY1_Rank5; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 7.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR049763; ANKFY1_BACK.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00248; ANK; 17.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 64..124
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REPEAT 250..282
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 359..391
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 427..459
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 460..492
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 869..901
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 988..1020
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1057..1108
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT COILED 7..34
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1113 AA; 121368 MW; 7C523ACEDD9411CE CRC64;
MGSLNQLDLL REEHLKLQSK YEQLRQQYAF LQAKVDPGQS PDAGSLAGEL FATMKNLFEQ
HTFSDIVIHV DGRDVKCHKF LLMTRSNHWN DLEGLESVEI KDTSFEAFEV VYRWMYMDVL
PRSKFSNELL KEVCQIAFRY HFSGLQARCV QLLKARVDVS NCISLYEFAD VENVIDLRDY
CGAVVAAHWS EFKPQQFAHL PAPSLFRLLK KNSHHVLHSI IQLNREDVLL LYFIENDSKV
SALVNAIDQT GLSPLELALT SGHINMANQL LSKNANCNAV DEAGKSILAR MIEKGRFVSG
DVFACEFLAS AGADLAFVHE KTRSTLLHFI ASSSSNQNAM AEWAESRLKE MSIDSTDAKG
RTAVLLSVVS GNLPLARVLI NNHADVVKAD GESRSPLSVA LFERNDLDLS AQIVKLGGIS
AVNHRVDKES LLHIAVKRDS LDISKFLLEN NAMVDVEDKS GATPLEVAVR QNNAGMVNLL
LTYGASVRPP RSGQNYILHT AVSKGAQMLK VFAEKAKDVD WSASGVLSYA LDEKALDCAR
IAVSAGAQVE SKDSEGNTLL IQRILQSDDA GATFLLEQGA KHLVKDSHGR SCFELAAFYG
LINTLRVICG LGVNINERTG GGFGYTVLKH ALSEGHYDCA TLLVSLGCDL ESVTADGSFI
QTMLHHFIDT ADEKAAVFLV QNGCNGNATR ASRDSGDEKE EVALHRAVAA GLNELVAALV
TAKVNLNWQD AQGRTACHIA IQEKNAEALS ELLKANDVSF LSVRDKVGQT PFSLAVVTKE
HSLAAAIVER QPHVALQTNG NGENLLHTSV KSNDLESVLF LLSTHTDATR VTTDGSKRSA
LHYAANVDNE LILRNLILAG CDVGLTAADG STALHVAVRA NRPVHTEILL ENGADPNLID
ERRENALLAA VRCGSVDCVK VLVANANVDS LAVNKNAQSA LHLCATLTGE KVPPRSSPAE
ICDLLLRREA GRLSDKEFGA FVDLRDADGN TALLLAYMAG NGDVCRCLLR GGATMGARNA
DGATMFTYET PTRLLLFRLL DSLEREPRWS DGDMCDCGVR FSITVRKHHC RHCGRLVCAK
CSEVTMPIAK FGEEKRVRVC SLCAEVLTTG CVR
//
