ID A0A016UEV3_9BILA Unreviewed; 265 AA.
AC A0A016UEV3;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Histone deacetylase domain-containing protein {ECO:0000259|Pfam:PF00850};
GN Name=Acey_s0044.g964 {ECO:0000313|EMBL:EYC13392.1};
GN Synonyms=Acey-hdac-11 {ECO:0000313|EMBL:EYC13392.1};
GN ORFNames=Y032_0044g964 {ECO:0000313|EMBL:EYC13392.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC13392.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:61930; EC=3.5.1.98;
CC Evidence={ECO:0000256|ARBA:ARBA00001028};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC13392.1}.
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DR EMBL; JARK01001380; EYC13392.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UEV3; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0004407; F:histone deacetylase activity; IEA:InterPro.
DR CDD; cd09993; HDAC_classIV; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR044150; HDAC_classIV.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF33; HISTONE DEACETYLASE 11; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 39..251
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
SQ SEQUENCE 265 AA; 29549 MW; B8365E4F53B7FEDA CRC64;
MERLLGSGFE DRKPWYLSSL YSPCILAKVV EVPIACIIPT CITDKYFLKR MRYQCGGTVA
ACRLALDRGW AVHLGGGFHH AYRSFGGGFC VYADISLALK ILFASKLINK AVIVDLDAHQ
GNGHERDFGN DHRVYILDIY NPRIYPWDHK AQEGISRSVH VGSMTSDAEY LKLVKHNLSV
ALSDFHCNLV IFNAGTDSLE NDPLGGLCLS PECIVRRDEL VFRLCRQNST PIAMLTSGGY
LMKSADVIAT SIRNLHEKEL IELKA
//
