ID A0A016UIZ5_9BILA Unreviewed; 493 AA.
AC A0A016UIZ5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=RhoGAP domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0039.g55 {ECO:0000313|EMBL:EYC14871.1};
GN ORFNames=Y032_0039g55 {ECO:0000313|EMBL:EYC14871.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC14871.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC14871.1}.
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DR EMBL; JARK01001375; EYC14871.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UIZ5; -.
DR STRING; 53326.A0A016UIZ5; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20821; C1_MgcRacGAP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46199:SF3; FI24033P1-RELATED; 1.
DR PANTHER; PTHR46199; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 172..223
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 242..428
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 19..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 55546 MW; CCA38D0E19D8124A CRC64;
MLLQNFECTY FLKRARNHSV GLRGRRSISA HDHPASSAKR SRSRLYDASA SAAINENEET
RDSPLPPKRS RETTEEITTT TTVTIDPSRR KPSQAKVTIR RSMNRSMSAN DLLNQEKATP
SAPRTPFVPR TASTLELTRI EIDTERIDED RTPLRAPWGG SWTMGKPLES RPHRFQPLSA
YFKITSCDVC HGGINFAAKP AYKCTDCLQL AHVSCSSRLV LPCVPRSVVF PRTPNKRGIQ
VYQLQEFCPS TPPMIAYPII HCIVDLENRG LSREGLYRVP GRKDHVQSVL NELRTSRGIP
KLNIQETEVV ADVVKAFLRD LRDPLIPKSS REEFIRAAQT DNHLALNNAV CDLPQPNRDT
LSYLMLHLQK IEALKELNKM TFENIARCMA VAIMGQPARE RDIQLASDLA REKERSVLQM
LKMSPDYWRQ FLKPGDGEPE SSGMGRTPAA PTTPYQPSCV DRSMLGPVTV SPAAPNLIRP
IPRRPQKFFD SPM
//
