ID A0A016UJE0_9BILA Unreviewed; 356 AA.
AC A0A016UJE0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN Name=Acey_s0038.g3542 {ECO:0000313|EMBL:EYC14957.1};
GN Synonyms=Acey-R05G6.10 {ECO:0000313|EMBL:EYC14957.1};
GN ORFNames=Y032_0038g3542 {ECO:0000313|EMBL:EYC14957.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC14957.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC14957.1}.
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DR EMBL; JARK01001374; EYC14957.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UJE0; -.
DR STRING; 53326.A0A016UJE0; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113:SF356; FI05912P-RELATED; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 96..340
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT COILED 46..80
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 356 AA; 40529 MW; 523CE8CB4D6B30D9 CRC64;
MFSHLLRLCR EWATSIPHDF RSEHMRTRLN ELLGLCSVDR NYKQKVTDLQ ASLRSAINKL
ERYDKAVKSL QKTLAENTQR PLQSDLLVGL ITVCSDAKVV AQQLTHIEME RFSMVGVDEI
LLALANNDLA DLGRNRNGPM GSISFYVEWF NRLSSFAATE VLRQLKKKHR VEVIEYLIDV
AKECCEIGNF NSLMAIVAGL SLPAITRMKR TWSRVEKSKL EILQHQLDPS GNFLSYRATM
KAAQWRAESA GSCQRIVIPF FVLLLKDLFL VFHGSVRSLP NGHLNFVAYS QIAEQLRSVV
RWKGVQCSFQ KNAAVLQYML VSPLYGEKES MLASFECEPA ESAAEREQLK KLKVRS
//
