ID A0A016VAZ2_9BILA Unreviewed; 1224 AA.
AC A0A016VAZ2;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=PLAT domain-containing protein {ECO:0000259|PROSITE:PS50095};
GN Name=Acey_s0014.g2501 {ECO:0000313|EMBL:EYC24431.1};
GN Synonyms=Acey-F27C1.11 {ECO:0000313|EMBL:EYC24431.1};
GN ORFNames=Y032_0014g2501 {ECO:0000313|EMBL:EYC24431.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC24431.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC24431.1}.
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DR EMBL; JARK01001350; EYC24431.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VAZ2; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 2.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR PANTHER; PTHR45901:SF6; LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45901; PROTEIN CBG12474; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF01477; PLAT; 2.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF89837; Doublecortin (DC); 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 2.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50095; PLAT; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 619..742
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 761..876
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 157..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1224 AA; 137979 MW; 204D6BC38FD51882 CRC64;
MIDIRRIRYV VTSSKYSRGI NLSALERLKK AREQAHQSLR RENHGGQSFW IPTSPSYKQK
LRMSRTLGFN VVPSRQVFFV LNGKGRFYRT LLNPLRLPSM EVLLHEISDG LQVAIFRLYS
MEGVRILNVN DILNLSPPKV IACPRIERPY LGTTMLPSIE THRSGGKMNK SASETSYTTD
GSQNENGIDK KPRSFASALK RNTRRTTGAH RKKPIKALPV IPQPPQKTPT VYKADDSDSG
KANSISSRLT DTPKLDEEPE FAFNEELEKT LREAEKHLIA EDDESSEHSP KSTPNVDSGR
EHSNTSRSRD GEETLPSTSR TADDFHARRS VMSEAERKAE MIREEKLGNV TDEEDFIRDD
DSDPIAGMYS DSDKEENLAS DVEDVGKEVA RARSSHSDRE ENLPSDNEEE RQRSRSSRAR
TLQARPTGTA DSEKEHILPS DDEAEEKPKS SRAITSESNR EDILPSDDDE PPPLGNPKIT
RRLTSQSSRE ETLASDGEFL DEEGTAAEAP KWSVPRTTDS DREENLPSDD EELNERERAA
IKIQAAFRGY RTRKSLKTVH FTEEPPNVIE TEGPIALAEE APDEKPAGAE EEAEQESVPA
AATMSPRTAT PGPGREKKMT YTISVTTGNR WGAETEAHLF IQMFGDEQTS RRFYLKQEAD
WLQTGETRFR QRHMDSFHVE TEDLGTINQI LIGHEQEGYG AGIFIDYVLI TENVVEGRQF
VCYCSKWFDS GQVDGKIERI LPVAAFYYLN SIPDESMTSQ GRWEFILHNG MEDGNGGTTS
NLHIIGYGTT GSSMMHINND KTMYTVPDTT LIQVDFGAIG DLLKVRFEVD GAGEKPDFYL
EWVELRDLDT EERIAVRVGK WMDFTGRHSK KPQAFREISV FRSGDQPLEI QNYEGKVYGG
DMRLLKDNTL QAQLIGDFSD SGVFPLIYNA NKKEYSFKVE CVHLGRINCI KVIGNFSEKG
QAILEGFSVL QDIWDKHVGS VETAGNILAV SAHVRESTHC PYRYVLRESK IRELDDKSYF
KVLTFSDMEG LATRNKKHKF TSDSDDWVLK MSIEGANNIT PEVSLCSGHQ SYPMNYQPDE
SNDTLYTYEM RGPSIGSLQK LRIGMGELEQ TEHLYIKKMR LANQITKTIL RFPSVDTEFE
SHQVYEFSPV YPDIQPTLNL LYTITLTTIA SSGTFRPVFN LIGEEGESGM RKFFDDTNFE
EGAVSSQLPV ALCISLPILG CVSS
//
