ID A0A016VMM9_9BILA Unreviewed; 1319 AA.
AC A0A016VMM9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Activin-binding protein {ECO:0000256|ARBA:ARBA00042260};
GN Name=Acey_s0008.g79 {ECO:0000313|EMBL:EYC28292.1};
GN Synonyms=Acey-agr-1 {ECO:0000313|EMBL:EYC28292.1};
GN ORFNames=Y032_0008g79 {ECO:0000313|EMBL:EYC28292.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC28292.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC28292.1}.
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DR EMBL; JARK01001344; EYC28292.1; -; Genomic_DNA.
DR STRING; 53326.A0A016VMM9; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR CDD; cd00055; EGF_Lam; 2.
DR CDD; cd00104; KAZAL_FS; 7.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 3.30.60.30; -; 8.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10913:SF45; AGRIN; 1.
DR PANTHER; PTHR10913; FOLLISTATIN-RELATED; 1.
DR Pfam; PF07648; Kazal_2; 8.
DR Pfam; PF00053; Laminin_EGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00180; EGF_Lam; 2.
DR SMART; SM00274; FOLN; 7.
DR SMART; SM00280; KAZAL; 8.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 8.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51465; KAZAL_2; 8.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 279..336
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 358..417
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 440..487
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 514..561
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 585..631
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 633..705
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 723..773
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 782..833
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 834..880
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 905..965
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 1152..1319
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 782..794
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 802..811
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 834..846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 836..853
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 855..864
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1319 AA; 143812 MW; CA571EF1B07CF2F0 CRC64;
MRPWIPVQES GLPVKESCLI RCRTALRLPS GYHIGSVPVS KQIPCEPSEE PTTLFCQLPV
WAEPPTPLHP RFALVGHLVV LGQPRSFVGD RTFPTFSAFQ CGSSPYSTMY LLVIQLAFLL
LVSHAIGKEC TVSRTSRSYL NDTFSTSQVL LSGTVERITV VALDENVAQT LNIRVRRIFK
GRELVGSPQY IDVAVPPRFK FCISALLLHD TRVFAISLRG TSLEISAPVI PVNLSVLDSL
HSFTWGKPHK KRRKSKQSEF FSKKGRCETQ LCPLGSKCVF STGKCECRTH CRSTGAAVCG
SDRVTYASAC HLYVRACLLA KKGKKLRIAN YGACRQKSPC EDLRCGPGED CIVSQKDGVL
SAQCVCPTSC PSYGDSVESS PVCSSQGVDY PSWCHLKQHA CHSQINITVR YFGECDPCAG
TSCARGTRCK LTEARRPECR CSEQCALIYD PVCADNGLTY TNECVMKVAA CKEDLQLTVF
KKGKCSDFRN PCDDLECSHH SRCQLFTNGT AICVCPQKCP LSLTPVCATD GVTYDNECEV
QRSACQLKSH IAVRHQGPCG KGLCSTFSCN APLVCVVKDE KPSCVCPQCT DELREVCASD
GRTYSNECKM RKAACEAGVT LFVKYNGICE GCAKKNCQYY SSCVVENGKA ECRCPTECYR
KLSSTQLTPV CGTDGVTYSS ECHLRKSACQ QMKFIMIAFE GKCDACLNVE CGFGEECRGG
KCLCSYQCPL SPPPSAKVCG EDGVLYLSDC HRQLAACQRG SPIPVVPLTR CHSAVATFND
ACQCHSLGSF GPNCDKDGNC RCRAGVGGAK CDHCLPGFWG LHLIATGAQS CKPCGCSSFG
SSRADCEQST GRCECSRGAR GEKCERCASD FVMTPSGCVA RQEFQAPRSC SFLKCHHGAK
CVESNVGLPD CKCPEHCSVD HLGIVANMSV CGSDGTTYED MCQLLQFACK HQLDIVAVSL
GICPQDSAEP RERNNRQREN SIEVDACLTG NCSTSTENER SLDLVMDGKR AYKVTSEGDN
VHMNVTLTVI PRSSNGMILF AKGDKTSFAL RCEMRRIVAD FGRDVLYSSE RLQLGSEQKI
ALTWSGRTAS LKVGGSVTSL AVANENEPLT ELSIGQYRGQ SLIGRIVQLS VNGRAVQRSD
VALCSGSRER YLSPVAFENG AYLELPQLDV GVKSKLQLEL SVRPLSKEGL LLLWSSSTTR
RNNVTYVALV LHESRSHLFL DIGKETVSLF GGPITTSSWT TIKFEVDPSN ASLYLNGSLA
ASKSFRGGHF TLGNSTVFLG GTHSGHSLPE ELHKYVRPFS GELRRLAINE RPFDLHEVR
//
