ID A0A016VUL0_9BILA Unreviewed; 375 AA.
AC A0A016VUL0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Potassium channel domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0004.g1740 {ECO:0000313|EMBL:EYC30732.1};
GN ORFNames=Y032_0004g1740 {ECO:0000313|EMBL:EYC30732.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC30732.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC30732.1}.
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DR EMBL; JARK01001340; EYC30732.1; -; Genomic_DNA.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF113; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..375
FT /note="Potassium channel domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001491153"
FT TRANSMEM 231..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 78..148
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
FT DOMAIN 200..256
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
SQ SEQUENCE 375 AA; 43207 MW; 5E91A0F45A22020C CRC64;
MRATLVFLFL ILAKGETSAQ SLPSVFPFKT RKTINIGVFF VRDNPRRINP SFDLKYRANR
QDKSAYVISY RSLRRTRACI STGVISSVYN LPQYIWGFTT ANELANAPRF PTVVIMTPNY
FTLSLALLSV MDHFGWTEFA FIYSGDESSE RCPIYLSDLQ VMIETFSEXR RKFPWVLPLN
HPEYIFGLDV QLSLPRDAPS WDFANSVFFT TTMLTSIGYG YVAPNTFGGR LFGVIYCLIG
IPLTLVTVAN VAKFISETIF LIHYELWKYW CRWKAKRKGQ ELNNEPLFAE DEDEQEILDR
VKLVRFPPIV VFLFVFLYGL LASYIIQRKE QWSYVESMYF TFISILTGGR AFGSRRKMGV
ANDALWIRAL CASGK
//