ID A0A016VUU4_9BILA Unreviewed; 2004 AA.
AC A0A016VUU4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=Acey_s0004.g2123 {ECO:0000313|EMBL:EYC31379.1};
GN ORFNames=Y032_0004g2123 {ECO:0000313|EMBL:EYC31379.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC31379.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368044}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC31379.1}.
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DR EMBL; JARK01001340; EYC31379.1; -; Genomic_DNA.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|RuleBase:RU368044}.
FT DOMAIN 139..193
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 267..327
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
SQ SEQUENCE 2004 AA; 229368 MW; 4314B365BA45396E CRC64;
MYSVRTFSSM SFPFLRKSSM GMSMDSGNTS FLHFGDIISL YTEETADLRG FLSTLGLVDD
RCIVELRDGR PESPPKKFRD CLFKVCPVNR YAAQKQFWTE QKRFLSGEST FDDDMMHKLR
IAAEKEKEQN ELEFRKTQGN VIQYGTTVQL LHVKSDKYVT VQKNSPAKCE RNAMKVYLDR
AGNEGSWFII EPAYKHYVIG DSVAAGNKIS LIPYSVNNQP SAGHVKHQLH LSHCLLKDHQ
TAAEVNCLNE STEWQVYMFL LFNENQPDIV KSGDVVRLFH ADQQTFLTLD SVPKTCPPQD
VVFLRMTNRP SAADATSSRA LWEVQVVQKD AYRGGAAKWR EYYRFKHLAT DMYLTAVPAT
SPVKPATNGR RASLMHMKTK AEFLAPPALY ADGPESTDEC SSSSTFFLVP VKSDFPEADK
KLLFCLDPGT MPKNKDVPTK SYVRLQHDAT NTWVHATNAS EKQNLYYSSK NEKGWVRVIC
ENSRVDKETF ALLPVSPNEV RDLDFANDAC RALRNFIRHI KSGDPVTKES INVTIQLLIE
CIFFVTNTTN HMMDPLQIND FSPSRDRQKL LREQEVLDQV FQLLKAPFMP RQGVTEIGPL
LSSPSDLSEQ RNEVFKTMFQ LCYSLLRYSQ VSYRKNQEFL AEKFGQIQEQ IGFDLLAEDT
MTAVLHNNPK LLEKYVKTPH IERFVELVRN NRLGKFLDYL ADLCVCRGEA NKKVQELICN
SVLSERHRDI FMETKLINDE VHIGWMGQQP RRLVDLAESA TYSTADAEFL DYYRHQLDLL
AQMCQEQQYL AIDPPPERKL LNISQQLPAE LVLKCMSDAR LPSEVRASFT RLMLHLHVVR
GSPLSAIRHA RLWADIPNEV KVQSYKTTSV EGYSDGGRAR VGDQFATDVL NTVESYLDSL
RHSHPNGPVL HKDAASVCTN KLTHEMVTLA KALAQFGYYT FDDLLTLTEN LLNIVDTSPH
SAQTARTVSH GMTMIHRVTQ SMIGGRPRMA DGHSKSVEKT SIEDTVKAKE SRQLLVKTKL
IVAEILQFVM DVRRDYRITM ALSWFKQNFP CDEHGVLNHT ANINERMAHE LYEAIYQSSG
HELHLDGGDG QLLLAILMQM TMSDYPPLTS IALKVLFRHF TQYQELLEDL KQVQLLVSSD
DVENYRQVDR DLFILKNLTE KSELWVHGDR HHSIDGKEHD KDEKTLLTME RIVGLIHHVH
DWRDKANEWL RTKMDFEEHE LNNSKGFATD ESLKAVVDII DEHYPNNRKE CLRLLNQLLI
SEDRNLAAAA LQELSDRTPL IAYPLIRQIL VRLKKLCYKK DRPDGMNQQL LKNMRVYEVV
LEFLSIPYDK KNDAEMPKLI TLSHEFLRSF CKGNKENQSR LHKFISIEKD SKEGTLRVET
EEEAATLVAI FRNNRELASN VSEDLVAHIV NLIEHKSRNA VFLELLQSFV CIHDKEIETS
QDKVATEICT ASDEVRALYV DNASFEQLDQ MMQNAPPYLD NTHPLKYHIE LVRLLAMCTR
GKNGSTELKC ASEIPMDHIV RVVTSPSCLI EVKVAYFQFL LHCYIDTDAE MKDAYKPEYV
DSLLHNMLKD VEKLQNELAK KTTSSSCAVL EQYICLTVTE ILLKFFEKPY SEQAKVDIHA
HKKMFTSLLQ HLSMLHAGSL KRSQSPKHWY RVDQCIKRLR KWAEENNIAL PASVVMPPFS
TVPTVKQRWQ CAANSARFIG QQTLTMRNRA NSLMMPGFPN PNNHNEKVAN VVTCYHMMIG
EFKFYLLPLH SAEGSVLVDV LHTPDLLFPV GSSLREKCAK GGVVTKLIQH CKTLMQNKQD
NLCTRVLQTL CRMCNGSRQN LSEQPIEFLL PLVDDPLQDF FNGQKLRSKL LQRYFGPHGH
LERQQSLSDG MDGIKSANQT EKEYEVAMEE RSLYDIQCRL NEAGASDLVI DIIINEPSRE
IFLKAIQLAK ALLLEGNDKV QQSFYNRLKK KDTHEPFFTA LSHRIQTAQN RLKSDMMSCN
ENKPKGAVDR LAKVVCMRVA LEIL
//
