ID A0A016WCG4_9BILA Unreviewed; 519 AA.
AC A0A016WCG4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN Name=Acey_s0807.g2448 {ECO:0000313|EMBL:EYC37301.1};
GN Synonyms=Acey-apx-1 {ECO:0000313|EMBL:EYC37301.1};
GN ORFNames=Y032_0807g2448 {ECO:0000313|EMBL:EYC37301.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC37301.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280815}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC37301.1}.
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DR EMBL; JARK01000407; EYC37301.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WCG4; -.
DR STRING; 53326.A0A016WCG4; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 1.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..519
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001490505"
FT TRANSMEM 382..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 127..167
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 203..232
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 234..273
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 276..314
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 129..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 158..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 222..231
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 244..261
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 263..272
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 304..313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 519 AA; 57483 MW; C4A2F25FFE02CA6D CRC64;
MCIYSSIFFA ALLATLTDLV AASGSLEVRL ISSRACSVKL CVKKPRAKPL DSCLLESQLI
FLQSQQQRLV STPFHFPFPE SFILVVELYD AQGGQLSQNT SKERFTVGTE FKPAAGSSEF
LDIAFRASCH SSYFGAGCQR YCKSSFSYTC DSEGRKICAE GWQGEQCDQP ICPDGCKHGR
CVEPGRCECD HGFFGSTCAE CRRSENCRHG TCRDDQPFTC ACEPGWGGIF CERDLEYCTR
HQPCKNDGVC TNGGVRTDFT CQCPEGFVGA TCDIELPSIC EHLGICRNGG VCTDADTRLG
RCICADGFEG RYCERRVVRS LCTATTCKNG GSCLDGSKCV CPQCLSGADC STIDEQCLWQ
RANATLTPTV TDHQSDVTEA RILMLMAFAS IMMLATCVVI FFLKYKKMKR ILRDPVTQNT
LNEHRQIHEL PNRSIDNRSP DEVYKVFVIP SKKSKDVDGP ASIEYETRYI SQPRGRYRTL
PCVDVSAAAE PEHHYAEIEY RPTTVSLDDK QLADNACSV
//
