ID A0A016WPA3_9BILA Unreviewed; 1238 AA.
AC A0A016WPA3;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
GN Name=Acey_s0561.g3477 {ECO:0000313|EMBL:EYC41634.1};
GN Synonyms=Acey-tag-163 {ECO:0000313|EMBL:EYC41634.1};
GN ORFNames=Y032_0561g3477 {ECO:0000313|EMBL:EYC41634.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC41634.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC41634.1}.
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DR EMBL; JARK01000161; EYC41634.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WPA3; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR CDD; cd01213; PTB_tensin; 1.
DR CDD; cd09927; SH2_Tensin_like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035012; Tensin-like_SH2.
DR InterPro; IPR033929; Tensin_PTB.
DR PANTHER; PTHR45734:SF10; BLISTERY, ISOFORM A; 1.
DR PANTHER; PTHR45734; TENSIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022912};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 968..1072
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 42..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1238 AA; 138138 MW; 3C634D01A3E52DF9 CRC64;
MQIFRHFLDS PKFCLLSIVI GSLITIYPSN FDESNGPVVY SEIRKKPSKE SKESKENKED
ATGEVAEPHD EIQTTSTDQA EMPPPPVPPK PRSASAMADP VVPELPERRG VLPAQVRPLV
QRPPSPREAG RATPSIEPDL VGKDRYDKAS KCFSYAPTKA LNEAFERPRK GSVTKVERRE
EEIQNIDPNE VSNAYIPHSE PARMPVQPKW DDEVESAKQL SGRASALQGV ACRRPITKAN
LMKCSFMAAL LDELARIPAR SQSVNAQPYY MRNDEAEERP VVVEQAQRAT PTPTSTIGGG
YRRRKRETKY GSYRTLNDDA YNDMDDLCDP DFYLNYTQPQ STPMNKTTAP KPPERAVPVP
EPRIHAGTRS VQLPRKKYQP VEAFTDPLDD ILASTAPAAA ASCVDLRDRD SHRARNCRSI
AALTGPTKTY AERRDSPYFR DRRLFAEDYD AVSEARDADD WLTHKLRKVK SKRDIDPDQM
RRRNQEKMLL EELKNATHDN DVTREVREAE FTVEGVGTRD PLAEYRREEE RLKNTHSPFE
DMPRRGRIRS KPPTPPPRER SRSPARSERA TPSIDSYSSY RNHNGVHEPS AHDFSNLGSI
VHGNASYSSK SEQNIPNGQL STVGRRDSRG MSHYEPRSES RPTLQRRQSF GTDRPPFQYA
DATIQRNNNE PTKFYSGQER VAAAIYRAET PQRELYASGT IHRAETPNRY YPENSAFSQR
SETPAFPIMR ETPLPFHPLL YAQNGTSRQD LDTTNTLNYR SASPRSQYAG QLSRRSSLVS
VVLLTTFFLL VALSSLELIS PGEGGSFDTR ARSLGRGVVA SFTRPTRICR RRLAPLQFRS
RRRCARRFAP HMACQAGPSE AVVLRLKSRD ISDVSLASSE SSGCSSERSS ILRSPVNLEE
TPVLHGTESS VSTDLPKPEV ASKESKASDA GTSSPAAVLP PPHLPKQNNT SEIIHHHPVF
VKDTSKYWYK PTISREQAIN MLRDKAPGTF VVRDSNSFPG AFGLALKVAT PPPGVAPGDG
TELVRHFLIE PSPKGVKLKG CNNEPVFGSL SALVYQHSIT PLALPTKLLL PEYDPATTPE
HVSATQALLE QGAACNVAYI GSLDCESLTG SECVRRAVAR TVEDTQRGLS RPVSVHFKVS
SQGVTLTDNT RKVFFRRHFP VNTVIFAGMD PADRKFDNYS VIGFHDQCVK SARLFAIVAR
KPSSMENACH VFAEFEPEQP ATAVVNFINK VLFANRRS
//
