ID A0A016X356_9BILA Unreviewed; 1470 AA.
AC A0A016X356;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Fibronectin type III domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0403.g834 {ECO:0000313|EMBL:EYC46271.1};
GN Synonyms=Acey-C27B7.7 {ECO:0000313|EMBL:EYC46271.1};
GN ORFNames=Y032_0403g834 {ECO:0000313|EMBL:EYC46271.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC46271.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC46271.1}.
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DR EMBL; JARK01000003; EYC46271.1; -; Genomic_DNA.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR CDD; cd00063; FN3; 7.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF30; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 2.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1470
FT /note="Fibronectin type III domain protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001491502"
FT DOMAIN 133..230
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 234..329
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 333..431
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 537..639
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 644..744
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 849..955
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 959..1054
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1040..1144
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1240..1340
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1424..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1470 AA; 164545 MW; 187D1121BEF492BA CRC64;
MVRFRLILAL FAISRAWLLH AEADLPPVSL NATVDPSLSI DVCMKANSSV HSPSSITGFK
IYFTRNSIVS GEKFRQWQNV EVLTSEPQYC IRLDAHNYDI RPSTMYRLRA TVLINQVESS
PSKLVLVNTK EAAAKSPVIQ SVNVLVNGSA IIQFIPAEDA DVITNYTLEY REVSNPDPTW
TGFEFESDSS NEVLLTGLLP NRTYEARLFA NGNVVHGHRS RTVPFHTNNT AQLPEISLDP
EEEIVLDPDV SLPLEVNCHV VSSPASNIHW LVDGQPIQAE HSFYTVTNSP VDDQKTTSTI
HIKSRTRNDN LTCVAANPAG QVSSSVAVRI RGPGSPPSAV TLQSERGGYT VAWAPPTHPN
GNITKYVVYH SSNKEDPLSD WQKLVLDGTE NSVRILSEAE DAFYVRVQAA ADSGPGVISD
IVAIEKDTAP ISVSLHYEDP PDREHLLIEP GEKVNVRCSA RGKPRPQLLY VITEENEDPE
AEEDVWTILE TATENDNVVG DVEFTTLSSK VLHCKAKNTA GSNSSSMTFA VRKPGDAPHD
VQVLSIDARD VIIVWKAPKF PNMNIESYEL LLNEDVSEDA EYWQKYLTTT RDNSVPMTRL
SLPTEQLKPS YQYFVRVRAI NQAGAGPLSE PIQFTTPNGG PENPPAQVSV DINEANIAVL
RWNKPNCTTE ILNYVIYFTR DLGISNEDYR EWQTVEVPAT ETKFKFDHQV GLKPKTFYRV
RVSAKNDVAE GPVSETKEFE TAHSELPIPT DIRTSVAEDN TLTITFSAVR DPDDHSNAIQ
RYKIELAQSD DVLNANWHPV NASSSSIDDM TSQVTIGIDG SRLARSSMYW VKITASLDNP
ARFVQASKPR WFRTGDGRLR TRTEIEGGPV VEKEPNLFET LRLVCRAEGS PLPEVTWYWN
DDPIESEKEG WTVQQEQSER VVVSTLTRSS VRESGLALCV AGNEDSNATA QVEVRVLGPG
SAPRDVRAVG WRNQINVTWQ EPLIANGVIM KYIVYYALRD AVDLSDWGKL ETDVTEIQVP
ATSPETRYLV RVQAATSDGP GIISDSVECY SDKHYQAIVM DLVSTNVDNF EAEPNQTVVL
RCSAQGQPIP RIFYAWDDYQ ENEITDVLIT ESTFHISGLF ERSALTNQTV ICRAENKHES
VNVRKVLIIR KPGDAPTNIT WTFDENDSLF IDWSRIRYPN GNVTYILYLS NFVDRVSGPP
VRIPQVPYNV NVTLQISAEN EWGEGEKSDP ITFLTPHGGP RNAPSLTSLL SKDMKVTMSW
LPPTQPNGEI KGYTIYFKKN HDAEDQPWQY VQVNANRTRF TIDESVGLEE DSHYKMKISA
TNERHEGPAS EISWFDTYVN IGEDLPAPEN VTAFLRNTSL VVHIPLKHAY QNYVIYVRPE
FSEQYWKYEA INVTETQETL VIQHFPLDKN DSYRMKISGL KHGRESRSSQ EFALTVEPEP
NEASPTEADT TEANKANAAE KRRIVKEPPL
//
