ID A0A017HDW4_9RHOB Unreviewed; 820 AA.
AC A0A017HDW4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Lead, cadmium, zinc and mercury transporting ATPase/ Copper-translocating P-type ATPase {ECO:0000313|EMBL:EYD72358.1};
DE EC=3.6.3.3 {ECO:0000313|EMBL:EYD72358.1};
DE EC=3.6.3.4 {ECO:0000313|EMBL:EYD72358.1};
GN ORFNames=Lokhon_01153 {ECO:0000313|EMBL:EYD72358.1};
OS Limimaricola hongkongensis DSM 17492.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Limimaricola.
OX NCBI_TaxID=1122180 {ECO:0000313|EMBL:EYD72358.1, ECO:0000313|Proteomes:UP000025047};
RN [1] {ECO:0000313|EMBL:EYD72358.1, ECO:0000313|Proteomes:UP000025047}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17492 {ECO:0000313|EMBL:EYD72358.1,
RC ECO:0000313|Proteomes:UP000025047};
RA Fiebig A., Goeker M., Klenk H.-P.P.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYD72358.1}.
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DR EMBL; APGJ01000004; EYD72358.1; -; Genomic_DNA.
DR RefSeq; WP_017928295.1; NZ_KK088650.1.
DR AlphaFoldDB; A0A017HDW4; -.
DR STRING; 1122180.Lokhon_01153; -.
DR PATRIC; fig|1122180.6.peg.1144; -.
DR eggNOG; COG2217; Bacteria.
DR HOGENOM; CLU_001771_0_3_5; -.
DR OrthoDB; 9807843at2; -.
DR Proteomes; UP000025047; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015662; F:P-type ion transporter activity; IEA:UniProt.
DR CDD; cd00371; HMA; 2.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 2.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00943; CUATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 2.
DR PROSITE; PS50846; HMA_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Hydrolase {ECO:0000313|EMBL:EYD72358.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000025047};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 165..191
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 197..215
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 236..258
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 264..283
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 417..439
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 445..468
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 760..780
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 786..807
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 4..66
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 68..134
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 134..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 820 AA; 82996 MW; B4FA4339DE26AB25 CRC64;
MTAQPTILRI DNMSCASCVG RVERALAAVP GVTEAQVNLA TEAATLRGGQ PGEIVAALDR
AGYPARRDRV RLGIDGLSCA SCVGRVERAL AAVPGVIEAR VNLATATAEV DRLAGGAPVA
ELIAAAQAAG YAARDADDRP SGNGAGATGD RKPAEAGQLM RRAGVAAVLT LPVVGLAMGA
HAIPGVHAAI AQGIGHWTSW LIQFVLTTLV LAGPGRIFLM RGLPALWRGA PDMNSLVALG
TLAAWGYSTV ATFAPGLLPE SARAVYFEAA GVIVTLILLG RALEARAKGR TGAAIRALVD
LQAPVARIER GGETVEIDAG ALRPGDVMLV RPGDRIATDG EVISGESRVD EAMLTGEPVP
VAKRAGDAVT GGTVNGNGAL RVRATAVGAE TRLAEIIRMV EAAQGAKLPI QGLVDRITAW
FVPAVLGLAV LTVAAWLLLG PAPALTHALV AGVSVLIIAC PCAMGLAVPV SIMVGTGRAA
SLGVLFRRGD ALQALDGVRV VAFDKTGTLT QGRPALTDLD ALAGQDEAAI LADVAALEAQ
SEHPIAAAIV AAARARGLAP QGAEGVEAVP GRGLKGRVGG RAVLVGNARL LSEAGVDPAP
LEDLARAQAG RGRTPVLVAI DGAPVAALAV ADPLRPEARA VVGTLRSMGV EVAMITGDSR
VTARTIAAEL GIDLVEAEVL PEGKVAAVQA LRDRGPVAFV GDGINDAPAL AAADVGIAIG
SGTEVAIESA EVVLSSGRIG AVADALSISR RVMRNIRQNL GWAFGYNIAL IPVAAGALYA
VNGMMLSPVL AAAAMSVSSV LVLTNALRLR GMQRIVEEGS
//
