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Database: UniProt
Entry: A0A022LRL2_9MICO
LinkDB: A0A022LRL2_9MICO
Original site: A0A022LRL2_9MICO 
ID   A0A022LRL2_9MICO        Unreviewed;       484 AA.
AC   A0A022LRL2;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   05-JUL-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=H489_0103720 {ECO:0000313|EMBL:EYT66251.1};
OS   Curtobacterium flaccumfaciens UCD-AKU.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae;
OC   Curtobacterium.
OX   NCBI_TaxID=1292022 {ECO:0000313|EMBL:EYT66251.1, ECO:0000313|Proteomes:UP000019755};
RN   [1] {ECO:0000313|EMBL:EYT66251.1, ECO:0000313|Proteomes:UP000019755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCD-AKU {ECO:0000313|EMBL:EYT66251.1,
RC   ECO:0000313|Proteomes:UP000019755};
RX   PubMed=23682147;
RA   Flanagan J.C., Lang J.M., Darling A.E., Eisen J.A., Coil D.A.;
RT   "Draft Genome Sequence of Curtobacterium flaccumfaciens Strain UCD-AKU
RT   (Phylum Actinobacteria).";
RL   Genome Announc. 1:E00244-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EYT66251.1}.
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DR   EMBL; APJN01000014; EYT66251.1; -; Genomic_DNA.
DR   RefSeq; WP_017887816.1; NZ_KB714628.1.
DR   EnsemblBacteria; EYT66251; EYT66251; H489_0103720.
DR   GeneID; 31842587; -.
DR   Proteomes; UP000019755; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019755};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897}.
FT   DOMAIN      175    303       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      387    456       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     183    190       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   484 AA;  54509 MW;  4A8884ABB40222F8 CRC64;
     MTMPADPVED LWSSVLRILA EDPRITPQLH GFLNLVEPKG VLAGTLYLEV PNDLTRGMLE
     QRIRIPITEA VARIGDDSVA NFAITVNPDM ASEPRVDPNV PEYAEPVQEA VEQSAAPRQY
     IEAPFVPSQI DSPGTSGRPE SRLNPKYNFD NFVIGSSNRF AHAAAVAVAE APAKAYNPLF
     IYGDSGLGKT HLLHAIGHYA ESLYPGIRVR YVSSEEFTND FINSIANNRS NQFQQRYRDI
     DILLIDDIQF LQGKDSTQEA FFHTFNTLHD HNKQVVITSD VAPKHLTGFE DRMRSRFEWG
     LITDVQAPEL ETRIAILRKK AQSDHLQVPD DILEFMASKV SSNIRELEGT LIRVTAFASL
     NRTAVDMALV QTVLKDLITL DEDNVVAPTD IINHTAEYFK LSVDDLYGSS RSQAIATARQ
     IAMYLCRELT SLSLPKIGQL FGNRDHTTVM YANKKITELM KERRSIYNQV TELTSRIKQD
     RRYR
//
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