ID A0A022Q448_ERYGU Unreviewed; 710 AA.
AC A0A022Q448;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
GN ORFNames=MIMGU_mgv1a002125mg {ECO:0000313|EMBL:EYU22771.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU22771.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU22771.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; KI632191; EYU22771.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A022Q448; -.
DR STRING; 4155.A0A022Q448; -.
DR eggNOG; KOG1979; Eukaryota.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748}.
FT DOMAIN 236..358
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 510..544
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 710 AA; 79362 MW; 6A1A9EBA2D2C93CD CRC64;
MDMEIESCEP IDMEESTPNP AHREPPSIRR LDEAVVNRIA AGEVIQRPVS AVKELIENSI
DAGSTSISVL VKDGGLKLIQ VSDDGHGIRY EDLPILCERH TTSKLSKFED LLSIKSMGFR
GEALASMTYV GHVTVTTITK GQLHGYRATY KDGVMENEPK ACAAVKGTQI MIENLFYNMA
ARRKSLQNSA DDYPKIVDLI CRFAIHHTNV NFSCRKHGAA RADVNSVATS SRLDAIRSVY
GVSVAQNLLS IEASDDDPSN SVFEMDGFIS NSNYAAKKIT MVLFINDRLV ECGALKRAIE
IIYAATLPKA SKPFIYMSIK LPPEHIDVNV HPTKREVSLL NQEVIIEKIQ SVLESKLRNS
NESRTFQEQK VPVRKMVRTD SQDPAGRLHA YLQVKPSSQL QGTSSLASVR SSIRQRRNPR
ETADLTSIQE LTREIDSSCH SELLDIVGNC SYIGMADDVF ALLQHNTHLY LANVVNLSKE
LMYQQVLRRF AHFSAIQLSD PAPLPDLIML ALKEQDLDSE GNENDDLKEK IAEMNTELIK
QRAEMLEEYF GIYVDQNGNL SRLPIVLDQY TPDMDRVPEL ILCLGNDVNW DDEKICFQTI
AAAIGNFYAF NPPLLPNPSG DGLQFYKKVP STTSEDGNAS GSADDSKEEE IEQELLSEAE
SAWSQREWSI QHVLFPSMRL FLKPPTSMAT NGTFVKVASL EKLYKIFERC
//
