ID A0A022QA70_ERYGU Unreviewed; 843 AA.
AC A0A022QA70;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0000259|Pfam:PF00931};
DE Flags: Fragment;
GN ORFNames=MIMGU_mgv1a019941mg {ECO:0000313|EMBL:EYU24163.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU24163.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU24163.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; KI632139; EYU24163.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A022QA70; -.
DR eggNOG; KOG4658; Eukaryota.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748}.
FT DOMAIN 162..401
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT NON_TER 843
FT /evidence="ECO:0000313|EMBL:EYU24163.1"
SQ SEQUENCE 843 AA; 96020 MW; AA0F76892F81CC16 CRC64;
MAATYAALVS LTHTIDQILN PPPHHHFNFD RDQINCLRQK VDFLIDFLEK NQSSTGGDHK
EIEDLETRIR VVAEGAEYII EDNVMNHILA GSEVDRSVET STLSEGVQTS IQDFDSIEEE
LVRIEKDHVQ HKNSITTEAS LSSSSSRPLL PIGKNIMVGF DGHVNEIMGA LSTDESNRQI
IPIVGMGGIG KTTLATHVYT NPFIVQHFHV RAWFTVSQEY TKKEILLGLL HKINNKNSND
AHDMNDEDEL GDKLHKTLFG RKYLIVMDDM WDINAWEMIN MFLPDNNNGS RILVTTRLLR
LAMDIGSCRP YQLNFLDEEQ SWDLLSQKIY ADKCCPVELE VIGRSIAKKC RGLPLALVVI
GGVLAKSKTE NWKYIEEDVT SAVRNQDDEF YMKILLLSYN NMPIYLKPCF LYFAVFPEDY
TIKVSKLVSL WVAEGFIRQC GHKSLEENGN EYLEDLIDRN LVLVDWRSIS GEVRSCRIHD
LLSNLCRTEA QKDNFILTRK LYNPNTLSYL KITQRLNING GKWKGMKLTP DTSPVPIRSL
LCFSPEDSND YTVDQVGLLR VLNGVDRYPI HEILQLINLR YVSCMGPMTA MSSSISRLWS
LQTLIVDGEL NLPSEIWQMP QLRHVEATRI HLADPPPDDV KNIILLQNLQ TLSTVIDLKC
TEAVIKRILN IKKFGIICPT FGSIFLRNLG HLHKLEELYL QCTPCGGDVV FPNSLKRLIL
RGCKIPWEDM SVVGSLPNLE ALTLWTNAVV GQKWISKEGE FTRLKFLYIY ECELEIWEAD
NTHFPCLEIL SLGYLNLKEI PSEFAEILSL QAINFDCNSN NDLLLSANEI SEQRENLGYN
ALH
//
