ID A0A022S377_ERYGU Unreviewed; 1287 AA.
AC A0A022S377;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=MIMGU_mgv1a000294mg {ECO:0000313|EMBL:EYU46804.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU46804.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU46804.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KI630171; EYU46804.1; -; Genomic_DNA.
DR STRING; 4155.A0A022S377; -.
DR eggNOG; KOG0217; Eukaryota.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd20404; Tudor_Agenet_AtEML-like; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748}.
FT DOMAIN 676..1016
FT /note="DNA mismatch repair protein MutS core"
FT /evidence="ECO:0000259|SMART:SM00533"
FT DOMAIN 1036..1228
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..193
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1287 AA; 143172 MW; 4F606C5921E1EBE7 CRC64;
MAPSKKVSNG RSPLVNQQRQ ITAFFGKKPD SSPSPSPSPS PALSKQNPNP NPNKSPSLSP
ITPSPLQSKR KKPLLIISPN LASSSSPPES RSSDKKSYGA EIVARRVKVY WPLDKSWYEG
CVKSFDKISG KHCVQYDDAD EEMLNLSEEK IELIEEPAKK KLRRLRRISV VDEEEEEEDD
LKELEDDSDD EDWVIKADEN KTLEDEDCLE EMDLEVEDEE SGRGDIGKKF NSRKLKVDEG
EQMVSVSNKK RKTGGECKSS ASKAPFAGDA EKLVSPLDSS KVGDDAERFV LREADKFGFV
EKNRKDAEGR RPGDVNYDSR TLYLPPSFVK GLTGGQRQWW EFKAKHMDKV LFFKMGKFYE
LFEMDAHVGA KELGLQYMKG EQPHCGFPEK NFSMNVEKLA RKGYRVLVVE QTETPDQLEV
RRREKGSKDK VVKREICAVV SKGTLTEGET LSTNPDASYL IAVTESCQIS ANEKGVHEFG
ICVVDVATSK IILGQLKDDA DCSSLCCLLS ELRPVEIIKP AKLLCPETEK ALIRHTRNPL
VNELIPFSEF WDAEKTINEI MGIYQRVSDR SCISEVNESL VQSSNSSLKN DGTNSLPDVL
SNLVSAGENG SQALSALGGT LFYLRQAFLD ETLLRFAKFE LLPSSGFGEI TQKPHMVLDA
AALENLEIFE NSRNGDSSGT LYAQLNHCAT AFGKRLLRTW LARPLYHIEP IKERQNAIAE
LKGVNQPYVL TFRKELSKLP DMERLLARTF AGSEANGRNA NKVVLYEDTA KKKLQEFISA
LRGCEAMTHA CSSLGAILEN VQSRLLHHLL MPGTGIPDVH SILQHFKDAF DWEEANHSGR
IIPREGADIE YDAACQIVKD IESNLKKHLK EQCRLLGNAS ICYVTIGKDA YLLEVPESLS
QSIPKEYELR SSKKGFSRYW TPVIKNLLGE LSQAESEREL KLKSILQRLI ARFCENHAKW
RQMVSTIAEL DCLISLSIAS EYYEGKTCRP ILSTSHPLEE PRLSAKSLGH PVLRSDALSE
GTFVTNDVTL GGPGHASFIL LTGPNMGGKS TFLRQVCLAV ILAQIGANVP AESFVLSPID
RIFVRMGAKD QIMAGHSTFL TELLETSSML ASATCNSLVA LDELGRGTST SDGQAIASSV
LEHFVRTVKC RGLFSTHYHR LAVDYQRDPK VSLCHMACQV EKGVDGVDEV IFLYKLTPGA
CPKSYGVNVA RLAGLPDTVL QKATTKSQEF ELSYGKRLKP NFCSQRWEDD AYLIIENLIK
IAANTDSMAV DSLANLQSTA RLLLQQY
//
