ID A0A023X336_9ACTN Unreviewed; 638 AA.
AC A0A023X336;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=PbuX: xanthine permease {ECO:0000313|EMBL:AHY46586.1};
GN ORFNames=RradSPS_1303 {ECO:0000313|EMBL:AHY46586.1};
OS Rubrobacter radiotolerans.
OC Bacteria; Actinomycetota; Rubrobacteria; Rubrobacterales; Rubrobacteraceae;
OC Rubrobacter.
OX NCBI_TaxID=42256 {ECO:0000313|EMBL:AHY46586.1, ECO:0000313|Proteomes:UP000025229};
RN [1] {ECO:0000313|EMBL:AHY46586.1, ECO:0000313|Proteomes:UP000025229}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RSPS-4 {ECO:0000313|EMBL:AHY46586.1,
RC ECO:0000313|Proteomes:UP000025229};
RA Egas C.C., Barroso C.C., Froufe H.J.C., Pacheco J.J., Albuquerque L.L.,
RA da Costa M.M.S.;
RT "Complete genome sequence of the Radio-Resistant Rubrobacter radiotolerans
RT RSPS-4.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; CP007514; AHY46586.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A023X336; -.
DR STRING; 42256.RradSPS_1303; -.
DR KEGG; rrd:RradSPS_1303; -.
DR PATRIC; fig|42256.3.peg.1320; -.
DR eggNOG; COG2233; Bacteria.
DR eggNOG; COG3195; Bacteria.
DR HOGENOM; CLU_017959_8_2_11; -.
DR OrthoDB; 9805749at2; -.
DR UniPathway; UPA00394; UER00652.
DR Proteomes; UP000025229; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0051997; F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0000255; P:allantoin metabolic process; IEA:InterPro.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.3330.10; Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 1.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR018020; OHCU_decarboxylase.
DR InterPro; IPR017580; OHCU_decarboxylase-1.
DR InterPro; IPR036778; OHCU_decarboxylase_sf.
DR InterPro; IPR017588; UacT-like.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR NCBIfam; NF037981; NCS2_1; 1.
DR NCBIfam; TIGR03173; pbuX; 1.
DR NCBIfam; TIGR03164; UHCUDC; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR Pfam; PF09349; OHCU_decarbox; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR SUPFAM; SSF158694; UraD-Like; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW Reference proteome {ECO:0000313|Proteomes:UP000025229};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 34..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 469..626
FT /note="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /evidence="ECO:0000259|Pfam:PF09349"
SQ SEQUENCE 638 AA; 67694 MW; DB4F04671B8E504E CRC64;
MSENGGVRRG AGRTHPVDEV LPAGRMAAFG LQHVMTMYAG IIAVPLIVAT ALELPAEQLV
YIINASFLMC GVATLIQTIG VWKFGVRLPI VQGTTFAAVT PMILIGSEYG LTGIYGSVIV
AGILTVIAAP FFGKLLRFFP PVVTGSIITI IGVSLMPVAI RWSAGGVPDA PDFGSPENIG
LAFMTLVIIL VITRFLGGLF GGFLSRVAIL MGLVFGTIIA ALLGAADFSG VGDAGWVGVS
LPFAFGAPTF HIIPILSMTL VMLIVMVETT ADILAIGEIT EKRVASNDVA RGLRADGLAT
ALGAVFNSFP LTAFAQNVGL VRFTGIKSRF VVAAAGGILL LLGLFPKLAA VVASIPLPVL
GGAGLVLFGT VAAAGIQTLS KVDLTDNRNL IIVAVAVALG VIPAALPEFY DGFPEAVRIV
FESGITAAAV AAILLNIVFN VLGGRGQDVG DYGENVAGVE EKLTVIDANR LDREAFAERF
APLFQGARWV PEEAYDEGHP FSNIQDMRHS FQMAVYDAPE ERQVELLRSY TPLSRAATAE
GGLSTLSVRE RRAVGLTTLS PEEDEEFQRM NAAYREKFGF PLVTAVRDHT KDTLLDDAES
RLRHSREQEI LISIVEVVKI ANYRLQDTVE ESLVGARS
//
