ID A0A024GJI9_9STRA Unreviewed; 2930 AA.
AC A0A024GJI9;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BN9_076520 {ECO:0000313|EMBL:CCI46697.1};
OS Albugo candida.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Albuginales; Albuginaceae; Albugo.
OX NCBI_TaxID=65357 {ECO:0000313|EMBL:CCI46697.1, ECO:0000313|Proteomes:UP000053237};
RN [1] {ECO:0000313|EMBL:CCI46697.1, ECO:0000313|Proteomes:UP000053237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac Nc2 {ECO:0000313|EMBL:CCI46697.1,
RC ECO:0000313|Proteomes:UP000053237};
RA Gardiner A., Kemen E., Schultz-Larsen T., MacLean D., Van Oosterhout C.,
RA Jones J.D.G.;
RT "Recombination and specialization in a pathogen metapopulation.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCI46697.1}.
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DR EMBL; CAIX01000137; CCI46697.1; -; Genomic_DNA.
DR STRING; 65357.A0A024GJI9; -.
DR InParanoid; A0A024GJI9; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000053237; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF72; SERINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053237};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1790..2452
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2550..2872
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2898..2930
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2930 AA; 336362 MW; B5D19FD5DFCCB829 CRC64;
MPLQTDIDSL VQLLEQHKNS HEERKPRLTS HAAYIAHQVE TCSALLLEGC GTILRKLQSI
LPNMLKLISS IDPEVAPKIL RHLCKLFMIA LDENTCPHIH LAFITPSYKT ARSDELEGDQ
ESSVQLSGFG TLYLYLVSFY CNQTYRQVRG DLLAVLEEFG MILQQYDPAA LAHILDDTLM
NIQQCLLQEK EQVRRGKCVL YPTTAIHMFR TADGALSQNN KKHILCGCDI SGNMEEKRSR
ARQLEQLLPS IKFAPDEKES ESRELWEAYA ITLIKNHPTV LSCGNINKRY VFETIKRVYR
FEQKKLGNRR VYETTLNLLY AVFSEFVSSD QALIEFGCFY FGTIDWKHNV DYGITTHVAI
ITQLERNSCN HSVSHFIWKS FDKWLLKMIE SDFFKEPQYQ ETAKTWIRVS IMFLQQYIDS
NGPLSTIAKY RFTTMLDIIR PRLDSDEEFF HEIARILHRT FGEDSTFLAK FMRILHTSLA
ISAIESRKRK RQLVKEREKM YTLSPTEQNS SQIHLQLAKW FLTQPDQGSH NARNADDTFL
EAFRLLGPLC WSRAATSFPE TESVRALILD RFDRATIDLS SDITEKRFRL VLMNLTLLLF
LVDDMQLQSR ANMYSTILSL IQTRKKLDRG YSIGTTWKAM CELAQILQNL PKGEIPSMPA
TCTSYLLLPY LVWMRSKPLR SLISEKWEDS IPLRVSCGGW SLISELNVQF ESILYSPLLI
IFLAREGVAS AEEVAEYLLE RIRLLMRENG KLTPELQTVL CKTVCAVVCL TYSTKYDTKQ
STTAGVMRRS GCILCHSNEN SRLNFSNYQV FITLIKDEDQ KKSTEAIMAR TELLCTILRH
LETSFMSTDD LIIIINDFLL GLSCEHKAAH RLIIASIGLL PQCLTLLDSV SMSIHREGFG
PEVVSLFREL LKSMENENDQ SRLHLVVRSI GAICRNCDKS NQAQMELLLL LMIQLVIFWS
YHQWRPEVAA IFYNAIKRIE NHHKLSWRRL CRNFPQQIYV PLIGKLLKYK TVCDFLHTFL
NDSVDPRTFL LASAPHTLPK YVAEQDEERL HLFQLALNEF QGTKLGSGES EDSNQSDVSS
ISDIILAQIE HIFKELIMQH IEHGDIGVEG TAWEFLFRYL PPKTTIRDVI FHSPIRVMNL
LVWELGGERF ETARRAFTQT LSYMYQDGSG EESESIPKDD TDQVFYPISR HYFLAVMTVL
STKIKTKDCL NEFGSSTRLR AVTCVGRLLE CLLLDKRGSK TALYGRTRGQ FVDPFVPKIM
ATLKILWIDD DIKLKEHGIR AWSTFVQLLS DKALGSNILA ILVSTLPYLG IQPEESAYSS
DTTSSTKKDQ PEHEQSIKGI VVELLEYIFV EKRSELRKSF PRVPLLPKIP ELSNVHAVLE
EEMGDCYSRP IEELISDLID ILRHWDSTVR ELALKQVYQC FIHRQNDVQG LIQSDFDPFI
HGTIAELMAT ILRLTKTEIK TENKLLCAMC LGAIGAIDAA HMPIHMSSSL TSASKQTGEY
TTKELACVLI ESLLVDELRA APDSTDSLAF AIQELLRFLG ELTTDPDVQS SNQSGEKGDL
PGWMKDRFES RNVLQYIEPY WSTGYTLSLS SDNNGQAPAE YDQNSTLYER CGKTYEDWIA
EWCKRLIHLS QPPEQKIFWA STAAVSSCPQ VARFLLPYLI QNVLRTGNSQ VYQEVKREIL
SVITNRDQYN ETIFTSSAHA EIGGVISQSQ YEDTYPNYAL ETHNDNHSRH HQCAQTLFST
LDELNDWVWA QEKKRNLTNG SNNTTNGLSE LDDQEKENLE EFLKDIPSRL LSNAAYSIRA
FARAVQYFEI HLRQQSNSLE CQYANTLDPS PVPLSVIMSN ISHVQLLYSS VNETDALVGL
ATIRRKNRAE SGEDQSNMIV QSIKLTDLLY KIVDYEQLAQ WEDALVCYEQ ALQQIHALPT
QFGIHNVSES HHGDQWNGEV KTLREKLYVG TVRCLIQLGR LESALQQING IVSTEPSFME
SLHQHALECT WRLSRWELLS DLLQSDKTNF STENNSVAQD PTQQLWSFPF FSRQKDVNGD
TSHIKFVRVL HNLHTKDAKA LSTNLRTARL EIMGPLAAAL GESYQRAYPM LHRLHFLHEV
EQGFAALSKV YDVSDESQRA DVWKRHCNWE SRYALIANSL RFRDPILALR RVLATKADLL
TDLSSNWLQY AKVARKEGFI RTATNAVMHA DLLCNPSASM EQAKLLIQQN RMYEALQTIE
PVEIDTSKLE FDAEHSALNA KRLLLATNWM QQFGLRQGKQ IIERYRAVIR LNPTCEKGYF
HLAKYFEYLL ATAYPSLHLN EERANDTSLS IAPDSGFHQL LINLMRNYIS TLKHGTKYVY
QALPRLLTLW FEYGELLHAG ALRKNKTMRQ MECAGLRENN WSSIVLSDIA QLIEEAMEIL
PVYVWLVGFP QVLSRICHPN PQVVEGVKQI IIKVLTHYPA QSMWPIVGLS RSLNAQRRNR
SRETIAYAQR IFVAREDQDN ATSFSEVMRL AEELISLAAH DPKNQRKMHI RLSRMRTKVL
LPIQANLTVS FPHSTHWDPP SERHVYINTF ADKADVLMTK EKPKRIEMLA SDGKYYPFLC
KREKTGDLRK DARMMEFNNM INKFLQKDTD ARKRKLRLRT YAVVCLNEES GLMEWVQQTR
AMRQLIGQIH KTELGFIQPF RLTHEIRDQF LAMQKKYAQD TKLMAAYFQQ KILTLPVFKP
RFHQWFHNNF SDPTAWFEAR STFTRSTAVW SMVGHIIGLG DRHGENILID CTNGECVHVD
FDCLFDKGLK LAKPEIVPFR LTPNMIDAFG ITGYEGVFRC VSEIIMRLLR NNRDALKNVL
ESFIHDPLVE WGRRGKGVQG SMSSTTIPEI SSERSKEETR IILKTIDDRL RGIYNLGDAI
RPLVSPSQRR MLPENEGFPL SVPGQVNKLI QEATSTENLA QMYIGWMPFL
//
