ID A0A024W905_PLAFA Unreviewed; 8458 AA.
AC A0A024W905;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=PFTANZ_02274 {ECO:0000313|EMBL:ETW36975.1};
OS Plasmodium falciparum Tanzania (2000708).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036725 {ECO:0000313|EMBL:ETW36975.1, ECO:0000313|Proteomes:UP000030708};
RN [1] {ECO:0000313|EMBL:ETW36975.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW36975.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI926394; ETW36975.1; -; Genomic_DNA.
DR EnsemblProtists; ETW36975; ETW36975; PFTANZ_02274.
DR eggNOG; KOG0939; Eukaryota.
DR eggNOG; KOG2266; Eukaryota.
DR Proteomes; UP000030708; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR11254:SF446; HECT-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030708};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT TRANSMEM 2238..2258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8123..8458
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 117..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2068..2102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2667..2699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2981..3007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3141..3176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3338..3373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4496..4621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4772..5001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5059..5145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5222..5253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5577..5622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5828..5914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5997..6072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6084..6175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6278..6350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6463..6585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6750..6811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7200..7272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7510..7534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7603..7638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7683..7702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7812..7852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7891..7910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7922..8017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 7054..7081
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2667..2686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2981..3004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3141..3167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3358..3373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4513..4621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4772..4821
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4832..4848
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4849..4870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4871..4993
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5080..5145
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5577..5609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5828..5898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5899..5914
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5997..6012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6013..6060
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6084..6114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6115..6133
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6134..6163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7210..7254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7255..7272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7603..7636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7685..7700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7895..7910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7922..7953
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7954..7973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 8425
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 8458 AA; 990229 MW; 9ADFDA3D27C3D7D2 CRC64;
MKIPIPKDDN FILMLDKLSQ EEKFFIHILS TCEDEHLLGH LYPFVDWVWL KSDLLAWAPV
LNRFDDLLRK YIIHNKLVMQ KKNNKNGDNE GSDYIVMNDR IQRITGCTLE YNYNNYNDNN
DNDNNNNDNN NNDNNNDNNS NNINSNNNNN NNNCENINLS CQSTCENGKK EFIPSDLLVE
EILRFTYNIL DNCLNKTKYN SIEHLILLLW SFNPKLSILC AEILNIYYLF IKKTKKNETK
INEIVNFVSS IINIPIPDHL HPYINNDIGR INDNNYISGL VLYYLHDKTN EQYMKNIYNK
VENKYFLDLI DYNIDLQKIN INVNNIDISF TSLFPTHIKY NETQNILNNA FNYIMENYNI
PEQYMYDVRH KLRIYVGLIC PKYRRKLFNL RYLILSGSLS INSIVSPQIV TSNSIFLEEL
LYFLKYHKYV HFNTLRIIFD LLITSIESHL YYKVVSDILG LRLHSGLFIS IFKYYLNYFL
SPYTLQKDIC PLYVMNESER EVYSINDINE YYIRKANPNI KNSLYSKEDT GHVYMNNDNT
NNKSHNNINN NNIINSNNNL NYYTLSDNDI LMNILRDSIP PHMMNMNNSE INSLIQASQH
ISNNNNYFNL VNTSVSPSQE QYFTPRAYTQ EQNVNNLNFN YNGSNLMNQS SIMNEQNVFS
SIPLETLGVI EANQMQNLDS SNVLNSSGTS VDMNIRSRNT EKDEIKYENY ISEETIINNI
KNCKKNGENE FFKVTKSYFK EFRKKKKHIS MMLQLLTLYH TCIMEPCPIL TIAQQNTLKI
FPLFLLDSST HNLPIVHLLL RIMETLLDFT PNFYFTVKDE EELYKILLSR FQYEFFLMSD
SFYHLNRKDY LRYYFEPFNY EGYDQEFIET NEQKEIYIKR KREEYFNYVN RIQDLCNMKN
MNNSDNIRNA CVNIFGGIGP NIYNGINNLT DVCIKNVIYN NDNNNDNNDN DIDIDNSTDD
DDDDDDDNIW NVECYDDKTM FSIKDKLLKS LFERYDVNVK VTDEVLLNRF NFWIKLYIYQ
ERMKIIKMII KALNLALKGY SPTDTLLDIF TNNYISVKII KYILRFPHKF GLCLYGYILG
FIYEHIYEDP TILSTLLKEG ILHIMLNGIV EQNLKDETVL IYVPSLLSLM FIHSIGKSTM
KKINYTPIYN LFHFVIQRDY FFFDRFGDIA VSVGNIINEL ENYGFVMKDF LIFHVKLLKN
LLIKGLKLGY WKSIDYDYIE KHVDNSIKQL QDMQLKDLNL NRYKYRKDKF LLDRLSILCR
FILSYMKTSW IKNFIHFNGL KILMTFTNLP CFPPNYIHIF EYHPIYSLIM KIYLYASFKS
LYNQFLYPLY NFTNFIMYTQ YVNFILNNKL IFDLDTNIVV VKKDELRNIL KMEPNTNNKH
NTNSCNNIHN NRESENAYKD LNKHKKNSYK YHMDNNKYLK KGNFCGPYID RNKLLLTNIT
HLFNILYFLI SAYTDAKGLY GNEEKLYDSP EISNRKILEV FSDVLTSIES VFDFFFTLYF
YQTNDLNNTI VLPLKDKICI HEHVKRTIRN NQNKSDYLLY NLFGCTRSLY CYSVNNNLYD
MTNKDKKIHF LCDEDNYVND YKFIDSLKKI DNDDKVYKAI YKYAFSHVIS EFHKYQNKNC
KTPSDITNYR KAEKSKFKRY FSNSEESIKR SLRKSNSTNP AVANHVNNLT KNVESIINNN
NINNNNISNN NNNININHNT ISSNNNNNNI NPFNNIKADI LCNTDDSGNF VDFSKLYNIY
NDRCQQEYKN KLNHRVNKDN KSEKCKKYND YYIDDKNIHM HTNYPYESKY VMCESLKSLL
VVIKKFFIMI NLACHTRQLK MKTSPNYIFY NVIQQKHILC IIRCITKCMM NVPLVSKPIQ
ENSYLERNHI YHILSDHITQ DKINYLNKLN DKKNKTNIHM SKNVCKNYIR KMSRDVQDNN
LIKSENGNNV STNNISFDMN HNNMMDQNKN SSIDYMSNNI NVNHYMYQTE CKKEDKYFNL
YDYSYTPYMN YNVENIEGIY PETFYMEEIL FKRYNFNFSN ISVTTNKQIY HNKYSNKENC
VNKNMSHVEE DADELFVMDS INNCNNMNVD MNNSNDNSDN NNNNNNNNNN NNNNNNNDNN
NDRCVDSLGG DFNHINNFSK YNKTYICNNT GNIKGLESID LNNLINIINN KNKTLNENNC
DSKNYEGKEK NELKKNKFNE KKMEQVSIHI QDYTPIKTIK YISEIINILH KLLSDNKLEF
VSYFYFLDLL YKVGTFDFIF NMFNYVMSVY ISLLSLYYKK KKENKQNCCS KFTSYIPIHV
SRNYTCTNTY FVRYIIRLML YYADSDVNTI KTYLQITVKS INTFLDFFIS LINIGKFNMI
LFCSKMLHPL TKIHNHFEGQ RVDPNVNKKE NEEEKNVSTN SEIKVKEDND KINGHIFNNN
TNDIHNNNNN NNNNSGISFD NNINNLSNEC ISIQNNTNPN YEGINMNSGF SNISNISNTQ
NFNNTNESLN YDNKINGDQN NFCTFEKNHI NNIKEVKDSN NENNTFSYNN NFLFSLDYFD
ILNTIRSVKC DISNNIFMWL TYINSTSVKI GNLGRNNIYI NFSNTIIYNF LKIILKFIHH
STEVEPKLNE LWMKEKNKEK KNVGNKDKEK DAFNYPNVNI LEEWGLMGFD EKTIYDCLNY
SGTTDLDCTL NYLDKAKEKE YFSNMSMDKS MSEKKKKNKD NLKSSYSEFD DNSSDSFSSA
SNRITDDIII SRNIMQCREY NNNLNDMITQ ETINNNSNVF PLTINNNGSN DNNNNDNNIY
GDSCNNNIYH SNNKLDEEKN EDIFYKDDKY ILEKFPFMFD LLKEAQKKSV HARIYYYDNI
MNPNNKRNMI FYIQYYLKSL RKNTFNSYEQ KNYIKAFWNE EKYLLLKQYI YKYIFNMLIN
IMLTIPYNEI SFMNLYLSFL IIDIDKKTVK LFLDQYKKTI HDKNSNKSRI FNHQDVKIII
LYYFIENISK KIKTLKNDEG IPYEPFYHCH HMFMNLHKKK NKGLKNSDDS TKQDKKKDNK
NIIQNKLPDA RNIQNIYNSN CPISSQNNNR SNNIITATSP NITLNISTIP NDNNVNIFNN
NNNNNNNNNN NNNNIIISVH DINPSTNIHV NNNNINNLSV VNTNNNMLNI NHVNNNRNRT
SNTIENNVLL HYPLNNLDNS YHSDDNPFNA YQDNNNNNNN TNLVDDKNGN KNNKDYQDKK
ILTNSTDTLN NDLNDEKNCI YGTKYAKGDI DVIYESQKDM EIYSYHFCLY MLFFTLYNVL
HKYNIAKNLI LNMDRNILDY CIFFIQKFNI SYIKCIENNV NYFLALVKNE RKIDNQEHNQ
KVKEQHHVEQ RQSVFLNDVP SCNVINVENV DMNLNEQDLI SKKNQEKNKR KRKYNKILSQ
SKGNTNNLDP SASSLESADK IMVSSSLEID GNIITNKMIH NHNNNNNNNE YNYMGCCNNN
MNEASINLNN DANNILKIHI NNNTSKNLNN PICDNHIITS TNNVISDNEM KKEKINIMYN
KGLVINKNLE THNMLIPYWN LADVDSSVSL TKTETNNNLM VENEENKYIS LYSKPPCFYA
PLFMCLYKII INYSLYNFND KNKKTNKKTK EEKYSEDKNM FLNNLKMEHY SMLNKNNTHI
NKSEKVFNTN EKRINVTVGT SNYNLSNNIK LPQTHMENVR YVSTEKQHNI IKICIDTLYF
FKGYNSHLCL SILSIIEYLT TTYNNVVFFI TYSPPNIYKD FKKVFQIEEQ MRQMNRRKNL
NQNDDNQKSF DKFHVNNNVI INASTKKAKE ELISNNDINV EKEIHKNNNN DNNNDNFNIP
PFYSVDGFKG ENSNFYEQKL SYFDLNDLIL NNMSRNSLDN YVIANRMESN LKSYFASHGI
PVKCFMKKDD LEVIENPKFA NALGVSLSEL NEALYPFIFK NPQIYEDILS CLCFFPNLKY
IKKSETNDLE KFGINTNVDD TYKFLEEKKK KLDPIGQVNT DKKKSSNFVM STNDNVNFDM
NIEYNNIINP SNNMNLQDFT KIDSLKNEGE KIKETNKNEE NMNDIYNNNI SNNNNISNNI
SNNNYYLNIL PIPEHIKSIY MLSEVAFSPR CLRKYHVKNN FYNFYILATL LDFLNLFTII
QSKTRLAKLS GKEEKEKFNK ALMEIYGTDA DFDNELEYKV MYPFALTADN MLFIINLLLK
TYKHLIVYLI KIPASFNQKI IKSFFQKEYG MYHFRGSMLY VDNSSFPYND IAINKESRLS
NFSSISNFSI TSKNKNNTDI NVNNNTNDDS AIYLLTKNND ENNKNEYPIM DLSNVLYKLI
RCDSVNTHTY KQISEYYLQN YMQYYSLFDL SNFTFRSCLF PFIYEKKYIT DIHNMDLINY
VSNINNSHNI VFTPFLIFLF KRILPQFICL NYPSLRSPYS LNTFKKKYPN MEKYYALRNN
ENKNLTYLRH IVNFIQLIFD IHNANYDIHK KVVLEIIHLL KIHSNFQKKK DNVNKNIKDN
DHVFSNVMDI FTYAISSLLY KMVNEEQNIK IQKPPNVEDD QCINKKKKVS EQFQLHQKGN
TKKIKKNDDS DYSNADTFTF NNRDNNNDND NNNNNNNNNN NDDDNNNHNN NNNHNNNNNN
NHNNNNNNHN NNNNNNNNNN HNNNNNNNNN NNNNNNNHNN NNNNNNNNNE DGNGENDDNN
KTFYYNREQL IMFRHSLCNL LNKLDYSKED FSNVATSIIR CLSVLTSAPV MGYPIKTKNN
KLFMIKLNKL NEKKNTKIKK IKRNKRRKNV SYVTFLNPSY VRFRSDSSNN DSECSDIPYS
DDSDISYEEH FIFDNGESDE EDDDIRYEYE EEMDDDYMEE EEIVNQEDGE EEDEEEAIEG
EDDEEAQDEE NDEEEGNNEN ETLFNDEYYN QTDNDNDNDN DNDNNNDNDN DNNNDNNNDN
NNNLLNDEEN NDMSNNDEEN DVERDDEDVE GDDDEDVEVD DDEEVDVDED EEEVDVDEDE
EEVEEMDDDM ENEDDDEDDI DDDDDEDDEE DVEDDDEVDD EVDDEVDDEV DDEEVLDDEY
DEIDIEDEDA AERNSNEVND NNRNVHVHAY LVQDRNEIDE DQIYDNSNDL LLPHEVDENE
EILSNMDDNN NNIVSRLDLV SDSSNDMDEQ NVHRIREIDE TEEDEEDDDG EDDEEDDDED
DEEDDDEDDD DEDDGEDDDE EDDEEDEDEG EEEYEDVEEE DGDEEELHIN NSTYNVNQNV
DNIRSNNNNT DLIDNEINVN NSLLNCNENQ HEILDILLEE DGAYNINDDI DEYNDDYVDE
VDNNNNNNNN NNNNNNNNNN NNNNNNRSNN NSFSNIVNID AQNINNNQMR NRMNTTNDIG
HINNLQENIN TNHMNSTSQY NMNGNISNIC NNTFAGQKSS SNERDVLENN VNNSIIIHNE
NSTHDHHINS SLLDNNKNQN ISNNISMIHN STIETKNNIL PNALENNIHN NIDTQNNLCN
NVNANSCSNN IYANTQTKSE KKGTIKNGIS LENNEENTNE HINKNNVIVG ENYILNNKIK
NEQINNTKVK NDHIIDSNIN NINNIKNDIN DNIIKVDKNN IKNNDSFAVK DKSMLESSES
TTNIRNVDEN NVSIIDLYYH FYGSNNRDIN TLLNENNSIL YLNETGQINS TQIKETNNKI
NNNNNNNNNN NNNNNNNNNN NNGNNTSVDN KDSKKTDKSN NTNDAEQVAL QLNNNNTEGV
EEFNNITSLN IENLMDQLYS TLLSTDIRTN DLLNNEIISL QNIANRVQRN NDFNNIVDES
SYNIIGDDIT ENRNLYDNRL NRNNSVPYIH RNVERLNNFP PLPTSNNNTN IRASWNNRNI
NRPNSITNNV VNNSLNNITS SIRNNNLRNI FNNIRNNNNN ENVFNRHRTI NIVPSIIRND
IIQNLSASHQ NNRDPNSSSS SSNNNNNNNN NNLTTNRDTN NTNERTNENN NIHNNNNIEN
DNNNNISQTR VNNNDQRQVS DLNKDKNQIK DKGSKIEKTE MLTKKYNKNQ AQFNMVDAVI
DNDTILKSAI CNRMYNRLCK AIPKVHIKLP LENLIEEKKR IIQTLKKQKE QEQLQENIKG
NDNNNNNNNS NKEHQNELED VNKNKGDQNK KDKKGNKDKK LSRFTTTTND KKKNTNEEND
IIESNENDNI TNAQLGSHNE QLENTELNND NNNNNNNNNN NTNNGFNPNE GDNDSDSDSN
SDSNSDSDSD DYNDNSDNNN NNDNNNDNND NNNDNNNENQ NNVNNDEDHL EEENEEDYKN
INYEELFDNI LNIESLLIIC CSLGISESQF LELLNVDRSF LIELPSNLID ELIIQHLKNI
TLTGISEKAQ DNIKNKKIIS IKMYKNYLKY QEYKKSQENN ASNENNTNDI LNNTTGNNIT
NDNNNNDNNN NNNNNDNNIN NNVSSANSTT NNCATEFNER PNNENSSVIQ NLDNNTNIQN
NINDEKEQNI RIFNSIKKSY LEALPSSIRS EIKKRIIGNR TERTDVQDET NISFIDSLTP
ELRRDVLSTA SIRFIRTLTD DMIEEARNLR LVILNNRNSA LNANNRNRQN VSNNDGANTT
ATNNRSVSDR NAQNMNNISN TNNTSTVNDT NNTNNVSNVS NVSNVGNTNN VNSVNNVNNV
SNVSNTNNMN NNNNNNNNNS ISSSSNNNSS SSSSNITSTT NRNINGSNVA NLINNIRNNI
QVRISNRALR NVSNNLNNSN HNHNNINIIN NINNINSINN MNIINNNNMI VNNFNRSNRN
SNRLVFTGGN RNNLNNRRRL NLPLRNSLSN MQRNNFIRIT YNENNAPVIM INTGHENYDS
LTVTRFIDNI MGIRTHDALA SGLPIGDSNN SSNYNNNSNN NNNNNNNSNS NNNNNNNSNN
NNNNNNNNNN NNNNNNNNNN NNNNSNSNNE RSRLFMSNQN RNVHHNNNVD HNYHVMNDDK
YLEKEDDMLL NRYLKNLFPS MNRFNTDNSK TSSLYICVEE PVPFQALIDI CRLLFLKKEI
NKKIMFTLFC NLTCSYQKTK VYTLQLFMNI LWCASADLHA KKNNPSIVYL NSINFPPKML
YYNMNKKHYG LFSDNYFITA SISAERVLEQ VQSLLITVPH ISSFFCTFLI HPSYFMPNDL
DENMITNNDK GNETNINQGN HNFMDVPYYG DKMIKNEKTD GEKKNNEIIN YQKEKDVEEE
KEYDDEAVIL EYELKRKRPK MDEKKKQKNQ ISDIYKNKTN INDKISTQVD MSKYEYPINI
LFKLLNSSLY LTSKKLMSHL LSVIYNLLIN CAKKNHNYAN FTRWVYEENL EEIISMENEN
NEEEVTSDDN NKNNNNNSSN NNNNNSSNSN NNKMSNDRNG TNPERNVSCT NKENTNKNKD
TKQKQNKEKE NFLSSTKIDK ELLLNIKSLK PIDEEIDKKD LISKPYYLLE VISKDALRNL
SKLICNYKTN FLWINNMNNT TNNNNNNNVN NNLEQVHKQD ISSLIQIMVM FFSHYKLKDL
IVQSLKRHTH VLIKRIIYDL KKIVHSIHNK TFNIYSVDHS DSLEQKLIAF YRVITILFNA
PTLIDSITNK NDLNKSDTIN LNNTNNSISN VEGVNTPVQE NDHINNNISN ENDCNINIMN
NVPNNNNQDN ISSEINTNET NNNKSFVNNN DMDNETIKND YEKHINKTRV DEETKFDICA
DFFLSINIDL LWEEFNKTMQ VINNSLIDKN YKFKDNYYYK DLNTTKDDNK KENNNDKLQT
GNVHKTNEKE DKNISNNLAD TQDNNIVTLF NTDSSSNDCS DHGDIYSNDR LSSNIQNEEI
ITNVENENND EKKKENDDEP PPTILNYLLP LMEAYLFIEE VILVSQYKLR KFKDLEKKVA
SLNVESIKIN EKLAYDDSPF YINIYNKKKM MKKKNKKYKS TKELLLDIFD DSHINSDPTN
LNKIKRKMCT NKLEQQQQQQ QQKQKQEEEE EEEEDDKKKI QNNYTHDDSM NNNIVENENI
NECINQNTNE KDHVEGQDQL VRNKLKKKKL NEDQTNDNNN NNNNNNIQQL NKREEMIVCG
NHDRQEKPND KENKNKNKNK NDRNNEQLDS NVNHDNVDEN NTNSFYNKIS NEQSNHKEVQ
KYQDSDIYDD DNDEDVDQYG NYYNEGKDDE EEDDDDDNDE YIQIKLEDNE GTINSRHKKL
IKFVYINRRV INSLIKQTPI LLHHNFKSLI KLTSSCINFE NKRHYLRKKL KYLKSGIRSD
PIRLSIRREK VFTDSYYQLR NKSGNDLKGK LVVTFKNEEG VDAGGLTREW YSILAKEIFN
PNYALFCREG KKSEFNHPNP LSYINPDHLH FFKFVGKFIA KAIYDGQVID AYFCRSFYKH
MLGRKILPAD AESVDPEFYN SLIKISEYKL EDLNLEINFS TEIDEFGKTK VIDLIPNGRN
IPVTDENKHK YIELLCELKV TNSIKEQLEA FMDGFKELIQ PKLISIFDDK ELELLISGIP
TIDLNDLKEN VEYHNYTANS IQIIWLWDVL QEFDENKKAS FLQFVTGTSR VPLGGFKNLM
GMRGAQKMII YKAYGEDRLP TAHTCFNQLD LPEYSSKELL KSKLIRAIME GKEGFGFI
//
