ID A0A045GRT1_MYCTX Unreviewed; 170 AA.
AC A0A045GRT1;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Cyclic pyranopterin monophosphate synthase {ECO:0000256|ARBA:ARBA00012575, ECO:0000256|HAMAP-Rule:MF_01224};
DE EC=4.6.1.17 {ECO:0000256|ARBA:ARBA00012575, ECO:0000256|HAMAP-Rule:MF_01224};
DE AltName: Full=Molybdenum cofactor biosynthesis protein C {ECO:0000256|HAMAP-Rule:MF_01224};
GN Name=moaC1 {ECO:0000313|EMBL:COW12588.1};
GN Synonyms=moaC {ECO:0000256|HAMAP-Rule:MF_01224}, moaC1_1
GN {ECO:0000313|EMBL:CFE49793.1}, moaC1_2 {ECO:0000313|EMBL:CFE58985.1};
GN ORFNames=A4S10_03245 {ECO:0000313|EMBL:OMH61056.1}, CAB90_03492
GN {ECO:0000313|EMBL:AUS52309.1}, ERS007657_00435
GN {ECO:0000313|EMBL:CFR66989.1}, ERS007661_00425
GN {ECO:0000313|EMBL:CNU29171.1}, ERS007665_00046
GN {ECO:0000313|EMBL:CNT93069.1}, ERS007679_02414
GN {ECO:0000313|EMBL:COV76156.1}, ERS007681_02142
GN {ECO:0000313|EMBL:CFE39754.1}, ERS007688_01567
GN {ECO:0000313|EMBL:CFE49793.1}, ERS007688_02746
GN {ECO:0000313|EMBL:CFE58985.1}, ERS007703_04196
GN {ECO:0000313|EMBL:COW77134.1}, ERS007720_01769
GN {ECO:0000313|EMBL:COW12588.1}, ERS007741_02466
GN {ECO:0000313|EMBL:COW42298.1}, ERS027646_00835
GN {ECO:0000313|EMBL:CKR86561.1}, ERS027659_04007
GN {ECO:0000313|EMBL:CKT14010.1}, ERS027661_01456
GN {ECO:0000313|EMBL:CKR49355.1}, ERS053720_02859
GN {ECO:0000313|EMBL:CFH88805.1}, SAMEA2683035_03203
GN {ECO:0000313|EMBL:SGI26709.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:COW12588.1, ECO:0000313|Proteomes:UP000044938};
RN [1] {ECO:0000313|EMBL:CFH88805.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH88805.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:COW77134.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K00500041 {ECO:0000313|EMBL:COW77134.1};
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000038802, ECO:0000313|Proteomes:UP000039217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGI26709.1,
RC ECO:0000313|Proteomes:UP000182946}, Bir 172
RC {ECO:0000313|EMBL:CKR86561.1, ECO:0000313|Proteomes:UP000048948}, Bir
RC 185 {ECO:0000313|EMBL:CKT14010.1, ECO:0000313|Proteomes:UP000050164},
RC Bir 187 {ECO:0000313|EMBL:CKR49355.1,
RC ECO:0000313|Proteomes:UP000049023}, C09601061
RC {ECO:0000313|EMBL:CFR66989.1, ECO:0000313|Proteomes:UP000046680},
RC D00501624 {ECO:0000313|EMBL:CNU29171.1,
RC ECO:0000313|Proteomes:UP000039217}, D00700688
RC {ECO:0000313|EMBL:CNT93069.1, ECO:0000313|Proteomes:UP000045274},
RC G09801536 {ECO:0000313|EMBL:COV76156.1,
RC ECO:0000313|Proteomes:UP000045842}, G09901357
RC {ECO:0000313|EMBL:CFE39754.1, ECO:0000313|Proteomes:UP000048289},
RC H09601792 {ECO:0000313|EMBL:CFE49793.1,
RC ECO:0000313|Proteomes:UP000046947}, K00500041
RC {ECO:0000313|Proteomes:UP000038802}, M09401471
RC {ECO:0000313|EMBL:COW12588.1, ECO:0000313|Proteomes:UP000044938}, and
RC P00601463 {ECO:0000313|EMBL:COW42298.1,
RC ECO:0000313|Proteomes:UP000048600};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OMH61056.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH61056.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:OMH61056.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH61056.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AUS52309.1, ECO:0000313|Proteomes:UP000236349}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Beijing/MYC004 {ECO:0000313|Proteomes:UP000236349}, and MYC004
RC {ECO:0000313|EMBL:AUS52309.1};
RA Guillen-Nepita A.L., Negrete-Paz A.M., Vazquez-Marrufo G.,
RA Cruz-Hernandez A., Fresia P., Naya H., Vazquez-Garciduenas M.S.;
RT "Clinical isolate obtained from a human patient with meningeal tuberculosis
RT in michoacan, Mexico.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-
CC dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate
CC (cPMP). {ECO:0000256|HAMAP-Rule:MF_01224}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic
CC pyranopterin phosphate + diphosphate; Xref=Rhea:RHEA:49580,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:59648, ChEBI:CHEBI:131766;
CC EC=4.6.1.17; Evidence={ECO:0000256|ARBA:ARBA00001637,
CC ECO:0000256|HAMAP-Rule:MF_01224};
CC -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005046, ECO:0000256|HAMAP-Rule:MF_01224}.
CC -!- SUBUNIT: Homohexamer; trimer of dimers. {ECO:0000256|HAMAP-
CC Rule:MF_01224}.
CC -!- SIMILARITY: Belongs to the MoaC family. {ECO:0000256|HAMAP-
CC Rule:MF_01224}.
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DR EMBL; CP024614; AUS52309.1; -; Genomic_DNA.
DR EMBL; CFOE01000261; CFE39754.1; -; Genomic_DNA.
DR EMBL; CFOH01000208; CFE49793.1; -; Genomic_DNA.
DR EMBL; CFOH01000499; CFE58985.1; -; Genomic_DNA.
DR EMBL; CFSW01000019; CFH88805.1; -; Genomic_DNA.
DR EMBL; CGCX01000093; CFR66989.1; -; Genomic_DNA.
DR EMBL; CNFU01000245; CKR49355.1; -; Genomic_DNA.
DR EMBL; CNGE01000098; CKR86561.1; -; Genomic_DNA.
DR EMBL; CNFT01001306; CKT14010.1; -; Genomic_DNA.
DR EMBL; CQPW01000004; CNT93069.1; -; Genomic_DNA.
DR EMBL; CQQC01000082; CNU29171.1; -; Genomic_DNA.
DR EMBL; CSAD01000331; COV76156.1; -; Genomic_DNA.
DR EMBL; CSAJ01000190; COW12588.1; -; Genomic_DNA.
DR EMBL; CHKL01000284; COW42298.1; -; Genomic_DNA.
DR EMBL; CSAE01000689; COW77134.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH61056.1; -; Genomic_DNA.
DR EMBL; FPTZ01000027; SGI26709.1; -; Genomic_DNA.
DR RefSeq; WP_003899917.1; NZ_WUCS01000017.1.
DR STRING; 1806.RN08_3427; -.
DR PATRIC; fig|1773.206.peg.561; -.
DR OMA; ENTTHAI; -.
DR UniPathway; UPA00344; -.
DR Proteomes; UP000038802; Unassembled WGS sequence.
DR Proteomes; UP000039217; Unassembled WGS sequence.
DR Proteomes; UP000044938; Unassembled WGS sequence.
DR Proteomes; UP000045274; Unassembled WGS sequence.
DR Proteomes; UP000045842; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000046680; Unassembled WGS sequence.
DR Proteomes; UP000046947; Unassembled WGS sequence.
DR Proteomes; UP000048289; Unassembled WGS sequence.
DR Proteomes; UP000048600; Unassembled WGS sequence.
DR Proteomes; UP000048948; Unassembled WGS sequence.
DR Proteomes; UP000049023; Unassembled WGS sequence.
DR Proteomes; UP000050164; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR Proteomes; UP000236349; Chromosome.
DR GO; GO:0061799; F:cyclic pyranopterin monophosphate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd01420; MoaC_PE; 1.
DR Gene3D; 3.30.70.640; Molybdopterin cofactor biosynthesis C (MoaC) domain; 1.
DR HAMAP; MF_01224_B; MoaC_B; 1.
DR InterPro; IPR023045; MoaC.
DR InterPro; IPR047594; MoaC_bact/euk.
DR InterPro; IPR036522; MoaC_sf.
DR InterPro; IPR002820; Mopterin_CF_biosynth-C_dom.
DR NCBIfam; TIGR00581; moaC; 1.
DR Pfam; PF01967; MoaC; 1.
DR SUPFAM; SSF55040; Molybdenum cofactor biosynthesis protein C, MoaC; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_01224};
KW Molybdenum cofactor biosynthesis {ECO:0000256|ARBA:ARBA00023150,
KW ECO:0000256|HAMAP-Rule:MF_01224}.
FT DOMAIN 19..153
FT /note="Molybdopterin cofactor biosynthesis C (MoaC)"
FT /evidence="ECO:0000259|Pfam:PF01967"
FT ACT_SITE 131
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01224"
FT BINDING 79..81
FT /ligand="substrate"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01224"
FT BINDING 116..117
FT /ligand="substrate"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01224"
SQ SEQUENCE 170 AA; 17845 MW; BA135681145FE414 CRC64;
MIDHALALTH IDERGAARMV DVSEKPVTLR VAKASGLVIM KPSTLRMISD GAAAKGDVMA
AARIAGIAAA KRTGDLIPLC HPLGLDAVSV TITPCEPDRV KILATTTTLG RTGVEMEALT
AVSVAALTIY DMCKAVDRAM EISQIVLQEK SGGRSGVYRR SASDLACQSR
//
