ID A0A045JS12_MYCTX Unreviewed; 967 AA.
AC A0A045JS12;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Membrane transport protein mmpL8 {ECO:0000313|EMBL:OMH58327.1};
DE SubName: Full=Transporter {ECO:0000313|EMBL:QGK77761.1, ECO:0000313|EMBL:SGH34619.1};
GN Name=mmpL4 {ECO:0000313|EMBL:SGH34619.1};
GN Synonyms=mmpL8_2 {ECO:0000313|EMBL:OMH58327.1};
GN ORFNames=A4S10_00476 {ECO:0000313|EMBL:OMH58327.1}, ERS007665_00567
GN {ECO:0000313|EMBL:CNU17630.1}, ERS007703_01352
GN {ECO:0000313|EMBL:COV41924.1}, ERS053720_00998
GN {ECO:0000313|EMBL:CFH74302.1}, GJE03_02345
GN {ECO:0000313|EMBL:QGK77761.1}, SAMEA2683035_00923
GN {ECO:0000313|EMBL:SGH34619.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:SGH34619.1, ECO:0000313|Proteomes:UP000182946};
RN [1] {ECO:0000313|EMBL:CFH74302.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH74302.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:COV41924.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K00500041 {ECO:0000313|EMBL:COV41924.1};
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:OMH58327.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH58327.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:SGH34619.1, ECO:0000313|Proteomes:UP000182946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH34619.1,
RC ECO:0000313|Proteomes:UP000182946}, D00700688
RC {ECO:0000313|EMBL:CNU17630.1, ECO:0000313|Proteomes:UP000045274}, and
RC K00500041 {ECO:0000313|Proteomes:UP000038802};
RG Pathogen Informatics;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:OMH58327.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH58327.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QGK77761.1, ECO:0000313|Proteomes:UP000388593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK77761.1,
RC ECO:0000313|Proteomes:UP000388593};
RA Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT "Complete microbial genomes for public health in Australia and Southwest
RT Pacific.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CFSW01000005; CFH74302.1; -; Genomic_DNA.
DR EMBL; CQPW01000066; CNU17630.1; -; Genomic_DNA.
DR EMBL; CSAE01000111; COV41924.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH58327.1; -; Genomic_DNA.
DR EMBL; CP045962; QGK77761.1; -; Genomic_DNA.
DR EMBL; FPTZ01000004; SGH34619.1; -; Genomic_DNA.
DR RefSeq; WP_003898458.1; NZ_WUCS01000008.1.
DR STRING; 115862.BBG46_02455; -.
DR PATRIC; fig|1773.206.peg.4114; -.
DR OMA; MIAMSED; -.
DR Proteomes; UP000038802; Unassembled WGS sequence.
DR Proteomes; UP000045274; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR Proteomes; UP000388593; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 769..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 905..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..388
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 610..943
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 943..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 967 AA; 105234 MW; 6301014031480484 CRC64;
MSTKFANDSN TNARPEKPFI ARMIHAFAVP IILGWLAVCV VVTVFVPSLE AVGQERSVSL
SPKDAPSFEA MGRIGMVFKE GDSDSFAMVI IEGNQPLGDA AHKYYDGLVA QLRADKKHVQ
SVQDLWGDPL TAAGVQSNDG KAAYVQLSLA GNQGTPLANE SVEAVRSIVE STPAPPGIKA
YVTGPSALAA DMHHSGDRSM ARITMVTVAV IFIMLLLVYR SIITVVLLLI TVGVELTAAR
GVVAVLGHSG AIGLTTFAVS LLTSLAIAAG TDYGIFIIGR YQEARQAGED KEAAYYTMYR
GTAHVILGSG LTIAGATFCL SFARMPYFQT LGIPCAVGML VAVAVALTLG PAVLHVGSRF
GLFDPKRLLK VRGWRRVGTV VVRWPLPVLV ATCAIALVGL LALPGYKTSY NDRDYLPDFI
PANQGYAAAD RHFSQARMKP EILMIESDHD MRNPADFLVL DKLAKGIFRV PGISRVQAIT
RPEGTTMDHT SIPFQISMQN AGQLQTIKYQ RDRANDMLKQ ADEMATTIAV LTRMHSLMAE
MASTTHRMVG DTEEMKEITE ELRDHVADFD DFWRPIRSYF YWEKHCYGIP ICWSFRSIFD
ALDGIDKLSE QIGVLLGDLR EMDRLMPQMV AQIPPQIEAM ENMRTMILTM HSTMTGIFDQ
MLEMSDNATA MGKAFDAAKN DDSFYLPPEV FKNKDFQRAM KSFLSSDGHA ARFIILHRGD
PQSPEGIKSI DAIRTAAEES LKGTPLEDAK IYLAGTAAVF HDISEGAQWD LLIAAISSLC
LIFIIMLIIT RAFIAAAVIV GTVALSLGAS FGLSVLLWQH ILAIHLHWLV LAMSVIVLLA
VGSDYNLLLV SRFKQEIGAG LKTGIIRSMG GTGKVVTNAG LVFAVTMASM AVSDLRVIGQ
VGTTIGLGLL FDTLIVRSFM TPSIAALLGR WFWWPLRVRS RPARTPTVPS ETQPAGRPLA
MSSDRLG
//
