UniProt: A0A045JYA6

Database: UniProt
Entry: A0A045JYA6_MYCTX

LinkDB:  A0A045JYA6_MYCTX 
Original site:  A0A045JYA6_MYCTX

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Ontology (1)   
   GO (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (11)   
   EMBL (11)   
Protein domain (8)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (1)   
All databases (22)   

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ID   A0A045JYA6_MYCTX        Unreviewed;       554 AA.
AC   A0A045JYA6;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Fatty-acid-CoA ligase {ECO:0000313|EMBL:COV32637.1};
DE            EC=6.2.1.- {ECO:0000313|EMBL:COV32637.1};
DE   SubName: Full=Long-chain-fatty-acid--CoA ligase FadD13 {ECO:0000313|EMBL:OMH58034.1};
DE            EC=6.2.1.3 {ECO:0000313|EMBL:COV32637.1, ECO:0000313|EMBL:OMH58034.1};
GN   Name=fadD5 {ECO:0000313|EMBL:COV32637.1};
GN   ORFNames=A4S10_00182 {ECO:0000313|EMBL:OMH58034.1}, ERS007665_00457
GN   {ECO:0000313|EMBL:CNU12659.1}, ERS007679_00963
GN   {ECO:0000313|EMBL:COV07058.1}, ERS007681_01870
GN   {ECO:0000313|EMBL:CFE39490.1}, ERS007688_00734
GN   {ECO:0000313|EMBL:CFE47409.1}, ERS007703_01142
GN   {ECO:0000313|EMBL:COV32637.1}, ERS007720_03215
GN   {ECO:0000313|EMBL:COW75486.1}, ERS007741_01965
GN   {ECO:0000313|EMBL:COW25283.1}, ERS027661_01049
GN   {ECO:0000313|EMBL:CKR33303.1}, ERS053720_00639
GN   {ECO:0000313|EMBL:CFH71628.1}, SAMEA2683035_00317
GN   {ECO:0000313|EMBL:SGH08399.1};
OS   Mycobacterium tuberculosis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1773 {ECO:0000313|EMBL:COV32637.1, ECO:0000313|Proteomes:UP000038802};
RN   [1] {ECO:0000313|EMBL:COV32637.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K00500041 {ECO:0000313|EMBL:COV32637.1};
RA   Murphy D.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CFH71628.1, ECO:0000313|Proteomes:UP000046674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0351H {ECO:0000313|EMBL:CFH71628.1,
RC   ECO:0000313|Proteomes:UP000046674};
RG   Pathogen Informatics;
RA   Murphy D.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000038802, ECO:0000313|Proteomes:UP000044938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH08399.1,
RC   ECO:0000313|Proteomes:UP000182946}, Bir 187
RC   {ECO:0000313|EMBL:CKR33303.1, ECO:0000313|Proteomes:UP000049023},
RC   D00700688 {ECO:0000313|EMBL:CNU12659.1,
RC   ECO:0000313|Proteomes:UP000045274}, G09801536
RC   {ECO:0000313|EMBL:COV07058.1, ECO:0000313|Proteomes:UP000045842},
RC   G09901357 {ECO:0000313|EMBL:CFE39490.1,
RC   ECO:0000313|Proteomes:UP000048289}, H09601792
RC   {ECO:0000313|EMBL:CFE47409.1, ECO:0000313|Proteomes:UP000046947},
RC   K00500041 {ECO:0000313|Proteomes:UP000038802}, M09401471
RC   {ECO:0000313|EMBL:COW75486.1, ECO:0000313|Proteomes:UP000044938}, and
RC   P00601463 {ECO:0000313|EMBL:COW25283.1,
RC   ECO:0000313|Proteomes:UP000048600};
RG   Pathogen Informatics;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:OMH58034.1, ECO:0000313|Proteomes:UP000189452}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6548 {ECO:0000313|EMBL:OMH58034.1,
RC   ECO:0000313|Proteomes:UP000189452};
RA   Bigi M., Bigi F., Soria M.A.;
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:OMH58034.1, ECO:0000313|Proteomes:UP000189452}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6548 {ECO:0000313|EMBL:OMH58034.1,
RC   ECO:0000313|Proteomes:UP000189452};
RA   Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA   Ritacco V., Bigi F., Soria M.A.;
RT   "Protein polymorphisms may explain contrasting epidemiological fitness of
RT   two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CFOE01000211; CFE39490.1; -; Genomic_DNA.
DR   EMBL; CFOH01000075; CFE47409.1; -; Genomic_DNA.
DR   EMBL; CFSW01000003; CFH71628.1; -; Genomic_DNA.
DR   EMBL; CNFU01000158; CKR33303.1; -; Genomic_DNA.
DR   EMBL; CQPW01000051; CNU12659.1; -; Genomic_DNA.
DR   EMBL; CSAD01000090; COV07058.1; -; Genomic_DNA.
DR   EMBL; CSAE01000088; COV32637.1; -; Genomic_DNA.
DR   EMBL; CHKL01000196; COW25283.1; -; Genomic_DNA.
DR   EMBL; CSAJ01000491; COW75486.1; -; Genomic_DNA.
DR   EMBL; LWDQ01000001; OMH58034.1; -; Genomic_DNA.
DR   EMBL; FPTZ01000001; SGH08399.1; -; Genomic_DNA.
DR   RefSeq; WP_003899837.1; NZ_WUCS01000001.1.
DR   STRING; 115862.BBG46_01000; -.
DR   PATRIC; fig|1773.206.peg.3408; -.
DR   OMA; CGAPIVY; -.
DR   Proteomes; UP000038802; Unassembled WGS sequence.
DR   Proteomes; UP000044938; Unassembled WGS sequence.
DR   Proteomes; UP000045274; Unassembled WGS sequence.
DR   Proteomes; UP000045842; Unassembled WGS sequence.
DR   Proteomes; UP000046674; Unassembled WGS sequence.
DR   Proteomes; UP000046947; Unassembled WGS sequence.
DR   Proteomes; UP000048289; Unassembled WGS sequence.
DR   Proteomes; UP000048600; Unassembled WGS sequence.
DR   Proteomes; UP000049023; Unassembled WGS sequence.
DR   Proteomes; UP000182946; Unassembled WGS sequence.
DR   Proteomes; UP000189452; Chromosome.
DR   GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:UniProtKB-EC.
DR   CDD; cd17631; FACL_FadD13-like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:COV32637.1}.
FT   DOMAIN          32..395
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          445..519
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   554 AA;  59906 MW;  3AC3100FAF0B9E88 CRC64;
     MTAQLASHLT RALTLAQQQP YLARRQNWVN QLERHAMMQP DAPALRFVGN TMTWADLRRR
     VAALAGALSG RGVGFGDRVM ILMLNRTEFV ESVLAANMIG AIAVPLNFRL TPTEIAVLVE
     DCVAHVMLTE AALAPVAIGV RNIQPLLSVI VVAGGSSQDS VFGYEDLLNE AGDVHEPVDI
     PNDSPALIMY TSGTTGRPKG AVLTHANLTG QAMTALYTSG ANINSDVGFV GVPLFHIAGI
     GNMLTGLLLG LPTVIYPLGA FDPGQLLDVL EAEKVTGIFL VPAQWQAVCT EQQARPRDLR
     LRVLSWGAAP APDALLRQMS ATFPETQILA AFGQTEMSPV TCMLLGEDAI AKRGSVGRVI
     PTVAARVVDQ NMNDVPVGEV GEIVYRAPTL MSCYWNNPEA TAEAFAGGWF HSGDLVRMDS
     DGYVWVVDRK KDMIISGGEN IYCAELENVL ASHPDIAEVA VIGRADEKWG EVPIAVAAVT
     NDDLRIEDLG EFLTDRLARY KHPKALEIVD ALPRNPAGKV LKTELRLRYG ACVNVERRSA
     SAGFTERREN RQKL
//

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