ID A0A059DBF4_EUCGR Unreviewed; 863 AA.
AC A0A059DBF4;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=EUGRSUZ_A00488 {ECO:0000313|EMBL:KCW88068.1};
OS Eucalyptus grandis (Flooded gum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; Eucalypteae; Eucalyptus.
OX NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW88068.1};
RN [1] {ECO:0000313|EMBL:KCW88068.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf extractions {ECO:0000313|EMBL:KCW88068.1};
RA Schmutz J., Hayes R., Myburg A., Tuskan G., Grattapaglia D., Rokhsar D.S.;
RT "The genome of Eucalyptus grandis.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR601577-2};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR601577-2};
CC -!- SIMILARITY: Belongs to the peptidase M8 family.
CC {ECO:0000256|ARBA:ARBA00005860}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KK198753; KCW88068.1; -; Genomic_DNA.
DR RefSeq; XP_010026317.1; XM_010028015.2.
DR AlphaFoldDB; A0A059DBF4; -.
DR STRING; 71139.A0A059DBF4; -.
DR MEROPS; M08.A01; -.
DR EnsemblPlants; KCW88068; KCW88068; EUGRSUZ_A00488.
DR GeneID; 104416623; -.
DR Gramene; KCW88068; KCW88068; EUGRSUZ_A00488.
DR KEGG; egr:104416623; -.
DR eggNOG; KOG1225; Eukaryota.
DR eggNOG; KOG2556; Eukaryota.
DR InParanoid; A0A059DBF4; -.
DR OMA; GICEFRC; -.
DR OrthoDB; 24037at2759; -.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.10.170.20; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.90.132.10; Leishmanolysin , domain 2; 1.
DR Gene3D; 2.10.55.10; Leishmanolysin domain 3; 1.
DR Gene3D; 2.30.34.10; Leishmanolysin domain 4; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR001577; Peptidase_M8.
DR PANTHER; PTHR10942; LEISHMANOLYSIN-LIKE PEPTIDASE; 1.
DR PANTHER; PTHR10942:SF0; LEISHMANOLYSIN-LIKE PEPTIDASE; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF01457; Peptidase_M8; 1.
DR PRINTS; PR00782; LSHMANOLYSIN.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601577-2};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|PIRSR:PIRSR601577-2}; Protease {ECO:0000256|ARBA:ARBA00022670};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR601577-2}.
FT DOMAIN 638..670
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT ACT_SITE 301
FT /evidence="ECO:0000256|PIRSR:PIRSR601577-1"
FT BINDING 300
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601577-2"
FT BINDING 304
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601577-2"
FT BINDING 380
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601577-2"
FT DISULFID 642..652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 660..669
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 863 AA; 94841 MW; F8AE4A92374580A7 CRC64;
MEVTVRRRSS LAVPWLVADL RFAIVLVEIV LFLLCSEAVN ASIAEKPHQW HDPGEGSEKI
VSHSCIHDQI LEQRRRPGHK VYLVTPQVYQ ESGVSKPLHR KGRGLLGLST SPFHQKDAKQ
PIRIYLNYDA VGHSPDRDCR NVGDIVKLGE PPANSLPGGP SCNAHGEPPV FSDCLYNCTQ
DDIAGDDKQR RLRKALGQTV DWFSRALAVE PVKGNLRLSG YSACGQDGGV QLPRDYVEGG
VANSDLVLLV TTRPTTGNTL AWAVACERDQ WGRAIAGHVN VAPRHLTAEA ETLLSATLIH
EVMHVLGFDP HAFAHFRDER MRRRSRVTEQ AMDEKLGRMV TRVVLPRVLM HSRFHYGAFS
ENFTGLELED GGGRGTSGSH WEKRLLMNEI MTGSVDTRSV VSKMTLALLE DSGWYKANYS
MADRLDWGRN QGTDFVTSPC NQWKGAYHCN TTQFSGCTYN REAEGYCPIV SYSGDLPQWA
RYFPQANKGG QSSLADYCTY FVAYSDGSCT DTNSTRPPDK ILGEVRGSNS RCMASSLVRT
GFLRGSMSQG NGCYRHRCVN NSLEVAVDGI WKVCPEAGGP VQFPGFNGEL ICPAYHELCS
TGLPPLSGGH CPNSCNFNGD CIDGRCDCFL GFHGHDCSKR SCPGNCNGHG KCLRSGVCQC
DDRYTGIDCS TEVCDEQCSL HGGVCDNGKC EFRCSDYAGY TCQNSSKLLS TLSVCQDVLE
IGKSGQHCAP SEPSVLQQLE EVVVMPNYHR LFPGGARKLI NNLFNKQYDC DAAAKKLACW
ISIQKCDKDG DNRLRVCHSA CQSYNRACGA SLDCSDLTLF SGETEHGSQC TGSDETAHIK
GLAMQGRSSK ALEALKQMFV LYR
//
