ID A0A059KPH2_9BURK Unreviewed; 3862 AA.
AC A0A059KPH2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=SDR family NAD(P)-dependent oxidoreductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=X805_09770 {ECO:0000313|EMBL:KDB53392.1};
OS Sphaerotilus natans subsp. natans DSM 6575.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Sphaerotilus.
OX NCBI_TaxID=1286631 {ECO:0000313|EMBL:KDB53392.1, ECO:0000313|Proteomes:UP000026714};
RN [1] {ECO:0000313|EMBL:KDB53392.1, ECO:0000313|Proteomes:UP000026714}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6575 {ECO:0000313|EMBL:KDB53392.1,
RC ECO:0000313|Proteomes:UP000026714};
RX PubMed=24965827; DOI=10.1111/1574-6941.12372;
RA Park S., Kim D.H., Lee J.H., Hur H.G.;
RT "Sphaerotilus natans encrusted with nanoball-shaped Fe(III) oxide minerals
RT formed by nitrate-reducing mixotrophic Fe(II) oxidation.";
RL FEMS Microbiol. Ecol. 90:68-77(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDB53392.1}.
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DR EMBL; AZRA01000025; KDB53392.1; -; Genomic_DNA.
DR RefSeq; WP_051631626.1; NZ_AZRA01000025.1.
DR STRING; 34103.SAMN05421778_10857; -.
DR PATRIC; fig|1286631.3.peg.964; -.
DR eggNOG; COG3321; Bacteria.
DR Proteomes; UP000026714; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08955; KR_2_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 111..533
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1523..1599
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1628..2052
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3731..3807
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 3697..3717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3862 AA; 407803 MW; FD43E75D7345849A CRC64;
MNRSAARPTP SADLAHETAH ADLPALVDLT VREVLGEARS GLYLRRRALR EMGLGSRELG
EIRARLAQRL GRDLDPLLFF RHATPEALIR HLRQPAGNGV TGHAANRPHG VEPIAIIGMA
CRFPGGVTTP DEFWALLAGG VDAISEVPPE RWDVATLHGD GPQQIRSRFG GFLEREIGRF
DAPFFRMAPV EAAAMDPQQK LLLETHWEAL EHAGIDPDGL QGTATGIFVG TFGDDFKLLQ
AREPDIGLYY GTGSANAVTA GRLAYFLGTS GPAFSVDTAC SASLVAVHQA CQSLHSGESD
LALASGVNLL LTPELSIAFS QAGMLAPDGR CKTFDARADG YVRSEGCGVV VLKRLSQAQA
AGDRVLAVIR GTAINQDGAS NGLTAPNGAA QEAVIRQALA AAGLQPHDIA HVEAHGTGTR
LGDPIEVQAL QAVYGAGRPA DQPLVLGSIK SNIGHAEAAA GIAGLIKLVL TLQHGLVPPH
LHLRELNPLL RDAAIVVPTA ARPWPARPGE PPRRAAVSSF GFSGTNAHAI VEEAPASAPV
ADAGPASLAP QLLVLSAQSP AALTELAERH VEALSRPSGP ALAAVAATLQ QGRAHLAHRL
ALVATTPQEA AARLQAWLRG EETAALCAGQ PAAEGSAPRI AFLFTGQGAQ YLQMGRGLYA
HEPLFRDRID RCDRVLREVL GRSLVELLYP DEAPAHQDLL TSHPCGQAAN FALECALADL
WRAWGIEPDV VLGHSLGDFA AAYAAGVLSL EDGLRLVTLR GRLMQAAHGR MLAVQASEDQ
VRPFLAGCTD VALGVINGPQ SVVISGATHG VEAIAARLAE AGLRTRVLDI PVAAHSPLLD
PVLDDFAAAV AAVPLAPPRL TVVSSMTGQP VGAELTDPDY WRRHLRETVR FADGVRTLAA
LGCEAMVEIG PQATLLGMAA LVLEDAASQG AASTGALLLP SLVPGTEDRQ AMRMALGSLY
TRGVQVDGLA LAGGQRPVPV ALPTYPFQRQ PYPVPAGRRP QAVAGAEAEA DALSSTLFVT
RWERQSRTPA LLAPAQAGRW LIVGEAKGLA DALAALLVEH GETVVRLDVG TVQEGTSATE
LSGMLATDAP APLRGVVFVP ASDDLADGET ASALDTRLQR SLGTLVTLVQ ALSAPQAETP
SDTKLWVATH RALPLHTDQP VTLVQTPLVG LGRVAALELG RHWGALVDLD AADNAAQRAR
ALATELLQPR PDGETEVAWR QGRRHVARLE RAPALAVSSP QPLSLQAEAL YWITGGLGAL
GLRLAQRLAD LGARHLLLTG RRATVEAQAQ SVLDALAARG VSVQVQAVDV SDAGAMGALI
ETLRSGTTPL RGVFHTAGVL DDGVLLNQDW PRIARALAAK VQGAWLLHRL TADLPLDLMV
SFASVAGLIG NAGQGSYAAA NTFLDGLARW RRRRALPALS VDWGIWADAG MAMRGEVLSF
PGVRPMAPER GLAALERVLS QADRWDGQVA IAELDLPAMA EARPGARLLA TLMPAAPAVA
APGANAAGHT PLRERLGALA PARRAAAMQA WLQQTVGALL GMAQPPDTTT GFTDLGMDSL
MALRLRHRLE AELGCALPST LAFEYRHIDA LAPFLLERLR LDEGPGPRPE ALPPTVADAG
AGAGAGDDEA IAVIAMACRF PGASTPEDFW TLVRDGVDRV GEIPASRWDV EALYDPQRPR
PGRMYVRQGA FLDDVESFDP LFFGISPREA AGMDPKHGLL LETAWEVLER AGIAPQDLLD
SDTGVFIGTG VDNHGGIHDV ADLKALDTYA ITSSGHSVAA GRLAYVLGLQ GPTMAVDTAC
SSSLVALHLA VRSLRQGECR LALAGGASLM LSPTMHVALS QMQVLAPDGR CKAFDAAADG
YGRGEGGAMV LLKRLSDARA AGDPILAVIR GSAINHDGAA SGLTVPSKHA QQKLLRQALQ
DARVPADALA YIETHGTGTP LGDPIELRAI GEVFGQTRPE PLRVGTVKAN IGHLEPAAGI
AGFVKTVLAL QHATIPRQIH FHTPNPHIEW DEFAVEVPVE NLPWPGGASA RRLAGVSSFG
ISGTNAHLVL EAAPMAGDLP RPNADAGEAD GAQLLVLSAR SEAALDALVT RWRTHLPAHA
AQPLAAMCHT AATGRRHHAH RLALVAHDRD DLARQLRALA EGRSAAGTSR GVTPPVRARL
AFLFTGQGSQ SVGMGRALYR DEPVFRAAID DCDRLLAALP ETPLSLREIL HPADPERDGE
PMERAGQAQP ALFALEYALA CQWRAWGIEP EWMLGHSLGE IVAACLAGVF DLADALKLVA
ARGRLMEALP QDGSMVSLRT TPDRVRPLLA GREDQVAIAA VNAPDSVVLS GRREAVAELV
AQLQAQGIEA RALKVTHAFH SPLMAPMLDA FRAVAETIRY APPTLPVVSN LSGALAGAEM
ACADYWVRQV REPVHFAEGV ETLRREGAGL FLEVGPHPAL AGLVARQLDL ASGMTLPSLR
RGVPDRAALL ASLGALFVHG HLPRWAALSP DSPAPRRVLL PTTPFQRQAC WARQPAVTAR
RAATALHPLI DRRFELPLHD EQVFETELSL QRWPMLAEHR VHGEVVSPGA CQLAMALAAV
ALAQGDADGP AALREVVLPQ ALVLPTDGGR QVQIVLGVDD TGRSLRLISL LPGQGKASLQ
THARALLGAP ADIGPPGESL AQLRQRCCRP GDPQQVWRRG EAAHIALGTA FRWIEALWHG
PAGARPETLG RLRLPATSSV LLDDPALHPG LLDACFQVAS LARDDEGGGT LLPFAVDAIV
LQHPARGEGW WCHAVQVGPD TWDLSLFDDP GRPLVQVRGF AMRAAPAAAI RRDPPWQDWL
HRVDWSRDAF GPDGVTALPA PAETVGALAA TLASDWAAQG GGAYETCVAD LETLAGAQVL
AAWRQAGVAF EPGARWTVAD LADRLGVVPA HRRLTGRLLE ILGELGWLVR DEGTGTDWTV
RAVPAEPDLA ALHARFEADH GAHAQGLPPE ALLLRRCGDR LLDVLQGRVD PLELLFPEGD
TRTAHRLYAE SPIHRLMNDR TAELVARLMA ALPAERGLRL LEVGGGTGGT TVGVLPRLPA
QRCDYLFTDI GPSFVMRARE RFAAFPFLRA QTLDIERSPL EQGFARGQAD VVLAANVLHA
TRDLPATLAH VRALLQPGGQ LLLLEVTTRS RWVDLTFGLT DGWWRFDDLR QDHPLLTAAQ
WRELLHAQGF ADIDVMEQGG HALIVARADL LDRPLPAPAV ARDWLLLGDA GGVAQALAER
LRRRGDRAIT VAPEAADSTD LGALIAQMPA LHGVVHLRAL DDSVDAAQAV DPVAAMAPAG
TSLLRLAQAL LQGRVPPAGL VCATRAAQAV VPGEEMSGWR QAGLWGMGRV FDQEHPELGA
VRIDLPARAG VRSDVDADAQ ALLAELDACD GVPVERRERQ IALRGGRRHR ARLQRCSAAE
AGVGIESVGT EALRCEAQAT YLITGGLGGL GLATADRLVA RGARHLLLLG RRAPDAAAQA
RLAALAAQGV EVRVAAGDVA DGAALAALLA SIDPRWPLRG VVHAVGVLDD RPVLHQDGAS
LDRVLGPKVR GAWNLHRLTQ AAGMRLDFFV MYAAAAGLLG NRGQANHAAA NTALDALAAH
RRALGLPALA IDWGAWADIG AAAQLMRERG AELVSRGLTA MAPEQALAAL EALMATGARA
PAHLGVMAID WATYLRSSGE VGRLPYFAAL AALQPPGTPA GSSSPVPGAG ATTTAAPVPL
RQQLAEVRGA ERAEILTGWL QQAVADTLRL TELPDSHTGF SDLGMDSLMT IELRRHLSRA
LELPLPSTIA FEYPSVAQLR DHLLAEMLAE PEVEPESAVA IDAPAAAVAA VAPDAFDDLD
LDQLSEAELG ALIDDELARL DD
//
