ID A0A061DIS3_THECC Unreviewed; 458 AA.
AC A0A061DIS3;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Flavin-containing monooxygenase {ECO:0000256|RuleBase:RU361177};
DE EC=1.-.-.- {ECO:0000256|RuleBase:RU361177};
GN ORFNames=TCM_001462 {ECO:0000313|EMBL:EOX92519.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOX92519.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOX92519.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate +
CC CO2 + H2O + NADP(+); Xref=Rhea:RHEA:34331, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17640, ChEBI:CHEBI:30854, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349; EC=1.14.13.168;
CC Evidence={ECO:0000256|ARBA:ARBA00035920};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU361177};
CC -!- PATHWAY: Plant hormone metabolism; auxin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004814}.
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000256|RuleBase:RU361177}.
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DR EMBL; CM001879; EOX92519.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061DIS3; -.
DR STRING; 3641.A0A061DIS3; -.
DR EnsemblPlants; EOX92519; EOX92519; TCM_001462.
DR Gramene; EOX92519; EOX92519; TCM_001462.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006909_2_1_1; -.
DR InParanoid; A0A061DIS3; -.
DR OMA; KELIWYG; -.
DR Proteomes; UP000026915; Chromosome 1.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0103075; F:indole-3-pyruvate monooxygenase activity; IEA:RHEA.
DR GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0009851; P:auxin biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR020946; Flavin_mOase-like.
DR PANTHER; PTHR43539; FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220); 1.
DR PANTHER; PTHR43539:SF77; INDOLE-3-PYRUVATE MONOOXYGENASE YUCCA10-RELATED; 1.
DR Pfam; PF00743; FMO-like; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Auxin biosynthesis {ECO:0000256|ARBA:ARBA00023070};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU361177};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU361177};
KW Monooxygenase {ECO:0000256|RuleBase:RU361177, ECO:0000313|EMBL:EOX92519.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU361177};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915}.
SQ SEQUENCE 458 AA; 51411 MW; 857ED96F5EB0464E CRC64;
MENVVVIVGA GPSGLATSAC LSAHSIPHVI LEREDIYASL WKKRAYDRVK LHLAKEFCSL
PYMPHPADSP TYIPKDIFLK YLDEYVSTFN IQPQYHRSVE SACYDEVDGK WRIEARNMQS
GDVEVYVAEF LVIASGENSA KYIPDLPGLD SFKGEMIHSN EYKSGSKYAN KDVLVVGCGN
SGMEISYDLS TFGAQTSIVI RNPFHVVSKE IVRLGMIFSK YLPVFVVDFM VLMMANIKYG
DLSKYEIRRP NQGPFHLKAT AGRAPVIDVG SVDKIKSKAI KVVPGISRIN GKKVLFEDGA
EREFDAIVFA TGYRSVAKQW LKDYEHVLNE NGLPKNNFPH HWKGEKNLHC CGLSRRGLFG
LSMDAKAIAK EINRVINEKN GKMKGSRRIS SLILCPWVRS PRTFPPSLLV LTANFLLITP
NSYFDTRTRV DFTPPCRYSP FQSIACLPPD PVLQRLAT
//
