ID A0A061DJ48_THECC Unreviewed; 980 AA.
AC A0A061DJ48;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|ARBA:ARBA00020830};
GN ORFNames=TCM_000994 {ECO:0000313|EMBL:EOX91956.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOX91956.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOX91956.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC {ECO:0000256|ARBA:ARBA00005315}.
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DR EMBL; CM001879; EOX91956.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061DJ48; -.
DR STRING; 3641.A0A061DJ48; -.
DR EnsemblPlants; EOX91956; EOX91956; TCM_000994.
DR Gramene; EOX91956; EOX91956; TCM_000994.
DR eggNOG; KOG2125; Eukaryota.
DR HOGENOM; CLU_004770_1_0_1; -.
DR InParanoid; A0A061DJ48; -.
DR OMA; RVKFGHD; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000026915; Chromosome 1.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051267; F:CP2 mannose-ethanolamine phosphotransferase activity; IBA:GO_Central.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR CDD; cd16024; GPI_EPT_2; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037674; PIG-G_N.
DR InterPro; IPR039527; PIGG/GPI7.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 757..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 849..873
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 893..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 937..961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 524..654
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
FT DOMAIN 771..959
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
SQ SEQUENCE 980 AA; 108422 MW; 131E6D7B06B4678B CRC64;
MPPLTCTKLA LITLTGVIIQ IIGLSLFVFG FFPVKPALTG TSGSESFHLP ICNSVGNQSE
TTLPSDQLRS LYKELSGIPS LFDRLILMVI DGLPAEFVLG KNGKPPSKQF LEAMPYTQSL
LASGLAVGYH AKAAPPTVTM PRLKAMVSGA IGGFLDVAFN FNTQAMLDDN LLGQFFRIGW
EMVMLGDETW LKLFPGVFKR HDGVSSFYVK DTVQVDQNVS RHLGDELSRD DWNLMILHYL
GLDHVGHIGG RSSMLMAPKL KEMDEVVKLI HSSTTQSQGN ARGRTLLMVV SDHGMTENGN
HGGSSYEETD SLALFIGLRN HDFDYASVIH QVDIAPTLAL LFGMPIPKNN VGVLITEAFD
SLKEDQRLRA LELNSWQLLR LLQAQLSGLP CRNFPCDVFS NHQSSGPSEC NHSTANMLCC
LYMEAEALHS SLKSKGGSEF ASNKEYSRTA AAYYKFLKSA SEWLSRRSTD KPVKLLAVGL
ATMFISCVIL SSLMFCWVRE IYLGGKRQPS NLNDSMNGWS LDETFILGVI LILVTSMGSS
SMVEEEHYIW YFVVSTFYLL LLRKTAQSLA PVGVQSSLGI HKGQSGKVYS RMCLIFLLLI
SGRILRGWHQ GGVNWTSLPD ISKWLELAGS HYVKLLQLIS AFLVISIGVC ALFSIESKGK
FFQMVRLSFL MSALLVLLHI IRYQDYTFSS TNYGATLLAQ IIYAILGAAT MGIVVALPWL
IPFSTFKICP TDNTLSPTSF FLSIQEKFPL VELRDSLYVI GWSYILCWCL LQLLLQQPIN
STPILLLLVQ ILASLLYFAS NETHHKEWIE IAALYYLGMA GHFALGNSNT LATIDVAGAF
IGISSHSTLL SGVLMFIITY ASPMFILLSL VMYISMKNTA HLVIPEKADA GDLLMMMLGF
PCLVPLVFNS ILLTAYTVVL LLMRNHLFVW SVFSPKYLYV CATTLCTYIG VSIVAATGIY
THLVLGIRKR KQVPISNNTR
//
