ID A0A061GID4_THECC Unreviewed; 1614 AA.
AC A0A061GID4;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Dicer-like protein isoform 2 {ECO:0000313|EMBL:EOY29630.1};
DE Flags: Fragment;
GN ORFNames=TCM_037118 {ECO:0000313|EMBL:EOY29630.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOY29630.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOY29630.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|ARBA:ARBA00035116, ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR EMBL; CM001887; EOY29630.1; -; Genomic_DNA.
DR EnsemblPlants; EOY29630; EOY29630; TCM_037118.
DR Gramene; EOY29630; EOY29630; TCM_037118.
DR HOGENOM; CLU_000907_4_4_1; -.
DR Proteomes; UP000026915; Chromosome 9.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18034; DEXHc_dicer; 1.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.170.260.10; paz domain; 1.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003100; PAZ_dom.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950:SF15; DICER-LIKE PROTEIN 4; 1.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF14709; DND1_DSRM; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00949; PAZ; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022759};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00657};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158}.
FT DOMAIN 57..234
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 400..569
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 584..674
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 1029..1173
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1214..1357
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1614
FT /evidence="ECO:0000313|EMBL:EOY29630.1"
SQ SEQUENCE 1614 AA; 181427 MW; 7784F575AD4422AF CRC64;
MPDGELSADG VEPPVTAKPK AYASPSPIAE VSEENGAKVE KKEKDPRKIA RKYQLELCKK
AMEENIIVYL ETGCGKTHIA VLLIYELAHL IRKPQQKICI FLAPTVALVQ QQGRVIEDSL
DFKVGTYCGN CRHLKNHQDW EKEMEQYEVL VMTPQILLRS LYHCFIRMDL IALLIFDECH
HAQIKSNHPY AEIMRAFYDK ATASTLPRIF GMTASPIVGK DASSQMNLPK SINSLENLLD
AKVYSIGDKE ELESFVASPV VRVYNYGPVD LGPSSSYMLC CSKLEKMKRQ CISTLGRKNG
DSQCARSTKK LLRRMHDNII FCLENLGLWG ALQACRLLLT GDNSERNELV EDEGSLSDDS
VCDRYLAQAA DIFASDCRRD GTAHDISDVE ILKEPFFSKK LLRLIGILST FRLQPNMKCI
IFVNRIVTAR SLSYILQNLK FLSSLKCHFL VGVHSGLKSM SRKTMKKILE KFRTGELNLL
VATKVGEEGL DIQTCCLVIR FDLPETVASF IQSRGRARMP LSEYAFLVNS GNERELNLIK
NFKNDEDRMN MEISFRTSTE VFTSLEERMY KVDSSGASIS SGYSISLLHQ YCSKLPHDEY
FDPRPSFFYF DDIGGTICNI VLPSNAPINQ IASTPQSSVD AAKKDACLKA VEELHKLGAL
NDYLLPLQKN AFEEETVLES SDSGSSEDED SRGELHEMLV PAALKEPWTN LEDYVLLNSY
YIKFIPDPED RSYKEFGLFV KSPLPKEAER MELDLHLARR RSVMTKLVPS GVAEFNRKEI
MQAQHFQEMF FKVILDRSKF LSEYVPLGNN EVFASSSSTF YLLLPVILHN CENKVMVDWK
IIKRCLSSPL FKTPAEAVEN GNFPSGVCLE LANGCRDVRD VKNSFVYAPH KVAFYFITNI
VGEKNGYSPY RDSGTLSHVE HLKMSDIHLK HPEQPLLRAK PLFKLRNLLH NRKPEDSESN
ELDEYFIDLP PELCQLKIIG FSKDIGSSLS LLPSIMHRLE NLLVAIELKH VFSASFPEGA
EVTANKVLEA LTTEKCQERF SLERLESLGD AFLKFAVGRH LFLLHDALDE GGLTRRRSNA
VNNSNLFKLA TRSNLQVYIR DQPFDPCQFY ALGHPCQIIC TKETEGTTHS QYNCQADHAN
SEVRCSRNHH WLHKKTIADV VEALVGAFIV DRGFKAATAF LRWIGIRVDF QHSQVNNVCA
ASKRFMPLCS KVDTGALENL LGYQFLHKGL LLQAFVHPSH NKHGGGCYQR LEFLGDAVLD
YLITSYLFSV YPKLKPGQLT DLRSVSVNNK SFANVAVDRS LHKFLICDSC PLSEAIGKYV
DFITSSPERG LFEGPKCPKV LGDLVESSFG AILLDTGFNL NRVWKIMLSI LDPIKSLSTV
QLNPIRELQE LCQSCNWDLK FLTSKSGRNF SVDAKVKAGD VPLAVSAINP NRKDAIRTAS
QQIYAKLKAL GYAPKSKSLE EVLKTSRKME AELIGFDETP VDVADPDTNG SAKMKLQQSV
ENDFNPRIHF INKAINLCKP RNSPVSSPMP SFEVKAGCMP SPIEVKGALP CSSNVDPACG
IDTPSRGESL QKTARSRLHE ICAINCWKPP LFECCEEEGP SHLRSFTFKV MLVI
//
