ID   A0A061ITS5_TRYRA        Unreviewed;       582 AA.
AC   A0A061ITS5;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=CNNM transmembrane domain-containing protein {ECO:0000259|PROSITE:PS51846};
GN   ORFNames=TRSC58_06948 {ECO:0000313|EMBL:ESL05405.1};
OS   Trypanosoma rangeli SC58.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX   NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL05405.1, ECO:0000313|Proteomes:UP000031737};
RN   [1] {ECO:0000313|EMBL:ESL05405.1, ECO:0000313|Proteomes:UP000031737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC58 {ECO:0000313|EMBL:ESL05405.1,
RC   ECO:0000313|Proteomes:UP000031737};
RA   Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA   Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA   Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA   de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA   Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA   Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA   Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESL05405.1}.
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DR   EMBL; AUPL01006948; ESL05405.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A061ITS5; -.
DR   EnsemblProtists; ESL05405; ESL05405; TRSC58_06948.
DR   VEuPathDB; TriTrypDB:TRSC58_06948; -.
DR   OrthoDB; 169356at2759; -.
DR   Proteomes; UP000031737; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51846; CNNM; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|PROSITE-ProRule:PRU01193, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW   Transmembrane {ECO:0000256|PROSITE-ProRule:PRU01193,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|PROSITE-ProRule:PRU01193,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        41..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..102
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   REGION          539..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..555
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..572
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   582 AA;  65467 MW;  CE8CD9CE0AB99603 CRC64;
     MGEALKENDD LASFVVSTLT ILIFTEVIPM SICKSKYSLR IAAAGCTLVH IAMVLVYPVA
     RFLGCLLDRF VPHDAGQIYD RNELRKLMVL HCEAHGDRSG LVRSEVQLLM AAMDFHERKV
     SDIMTPIEQT TVVKAEEVIT TELIEWLWAC GRSRIPVVQL PNNYIGVLLV KDLLMVPVPI
     NDVDPITIGE LVKAKSRGFA TVNLNASLPS LLRALQHSKT HMFLVTSEVE LDEATPKEGD
     ETNFFHSPIR KPFFEKGENI VGVVTLEDVT EALIKGEIYD EYDRHEFSVD DHSNCHCASL
     FIYTEGILMP LQEPERVPRA NFYSYYVHNS QNIALTESQV WSVAYYLTRA VTAFFLWRPG
     YVKMLLDECG DEQLIPPTTP FAEEASVEAT PIRLQRFSPT SSPVASERSE STRISPHCLL
     GISRADICTN PLSLVRDERF ILYHEGVATD IFTLVLGGEV VASVGPSHFP LKRRSFQWLG
     EGALTSLNYT PDFDAVVLSP TRLYRIPKEL YTRYLGYNDV YSKIYDKCVM MGIGSADVSQ
     HSPPNMSLTQ RSEGHGQRQS RGDDKEGLLR RRKGNNLYGT FE
//