ID A0A061IU09_TRYRA Unreviewed; 2279 AA.
AC A0A061IU09;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN ORFNames=TRSC58_06839 {ECO:0000313|EMBL:ESL05510.1};
OS Trypanosoma rangeli SC58.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL05510.1, ECO:0000313|Proteomes:UP000031737};
RN [1] {ECO:0000313|EMBL:ESL05510.1, ECO:0000313|Proteomes:UP000031737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC58 {ECO:0000313|EMBL:ESL05510.1,
RC ECO:0000313|Proteomes:UP000031737};
RA Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESL05510.1}.
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DR EMBL; AUPL01006839; ESL05510.1; -; Genomic_DNA.
DR EnsemblProtists; ESL05510; ESL05510; TRSC58_06839.
DR VEuPathDB; TriTrypDB:TRSC58_06839; -.
DR OrthoDB; 37271at2759; -.
DR Proteomes; UP000031737; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039891; VWA8.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR21610; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR21610:SF9; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF07728; AAA_5; 3.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..2279
FT /note="VWFA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012271921"
FT DOMAIN 2090..2272
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 398..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 968..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1907..1949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1907..1924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1927..1941
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2279 AA; 250294 MW; 3EA8DC64862832C3 CRC64;
MVLFLPASLI TCVSLFCKWK RTRMHKGIIT FMFRHRQRTL IGMLVHHTMV GSAPPFTRST
LLAQGRGSSS DGLLLTIGDV TVPVPTSLHH PEHVNWLPPG AATCGSGTNK EDARDDIATS
DFDDRGLQLH GGNAFFQMQD PTTLSYLRWM CQKEQLRQDM CLVGEPGPAL RWLVQMYSYI
VRREVQYLSL NRDTTESDLG QRREIRNGTL IYNDQCVVVA AREGQLLLLE GLEKVERNVL
PVINNLLENR EMHLENGMML IHPERYDRLL QELLTAKRGR YEHGGSEGRG EDADGAMRHA
AAQEELRRMG FIRVSENFRV VGLTFPVPPY EGNPLDPPLR SRFQCLYVDI PLPGLAVTQG
GVTAAAAVGD GRGADATESL LKLRAIIDEV NTSTKDFILG GKQSSGGRGK TSNNPQTNNG
GGGGGAAMTH CGLQTIGSYE LAVLSRQLQL FPDIPVGELL PRAFPWTLYA QQTTTAGAAH
IEEATRRRRE YERVLAACYI GTPLYECRRD STDADIDNFG TVGECATNYR ASRDFSLTGG
KGKMRQIQRG NVTFQRRRSS CGGSERSTEV DRSPEEFNDV LQVENIRVAE HSCNTVVGDA
CIACSKDGGT YRLPIYMGES AVPATREEAA KGIVVAERCP TPCSVFTPAH YHVLQSMLQL
HIAGQHILLL GPNGCGKTTI LREFAHLLGY RMETMYLYAD MTSKDLFQRR TTDSSAGDTR
WENSALVEAA LGGHIAVLDG IDKLPNGMLS SLQQLLVDGS TSLYDGTLLR SQREYEVLKR
ELMATDEEMR VRRIFSVHPS FRVVATARYK ASAGSCGGGC GKANQGSWRV THEVTSLFGL
VMIPATTRTT LHAVLSRMAT TELQEWRKEM GVLAEEDSST MDETTLEAVT RDIDRLLRLC
DALERLQETE PKIPQLSLRQ LLHLIRFRVR YPEDFTPGVE SALLLPLMNA LTAEQVRQVM
HSCGFDDVSR HEPEQQRQQH PYRQARKTAE TEADLLEGRR SKRHDVLMEL KVSNTLNTDT
DNNGCVPARV FGVHSKPIFC SNRLYSEEEQ AMVPYVPYFH SNPVHESIIA WLAKQYAVGN
SILLIGNQGV GKNKVVDAFL ARIGVPRQYI QLHRDTTVGT LTINPTVEAG RVVWADSPLV
KAVQRGHCLV VDEIDKAPVE VVQVLKGLVE DHEMRLRDGR QIRGPRAHAV AAGRGALEEA
NIITMHPDFR IIVLANPPGF PFHGNDFYRE CGDLFASYVM GNPDALSQLR VLKAYGPNIP
DGLLVRLIGA FQCLQKSFEE GHLTYPFSLR ELIAVVKHMA AFPHDGIYDA LNNVFNFDAR
NENTLHLVRQ VLHLHLHPLM SAGGMRRLLP LRAGQPLPLQ VLQQPLEVPA ASSALPTTSA
MGDTASLPVR FLTDAECGGP CSVQFVSTWC ERYREAEFAA IVPNGESEGF TEWLAAPRLP
FLRAGDVVLA ITPMDTDVRT GALVTLAVLF LREEDPSDAN HKSNGGRRVL VAMVAPQSVV
SLGMAAVRRS HLPPGQIQFF DLTQFLPAVA ASSVFSVSAP LLLAFSAESH GTSLAAAAPA
DWLQDAFSVP TPLVAVVDAP SGFVLLINTL TAAAPSSHVA PERHAAAEEC TRGAVLPVRL
APPFSEASSC RAFVRPLGSV VAMTRARSAE LFVWMNAHRI VVELPAVSID TVQFVTDNLA
MVSLQVGETI LKCVLKVAVS EDGEAKASLC QLPNGMTGDI VGFVGNQAPV SLSDQALLQP
LTPDELKGAV IVPSGNGASR GDAVYMTVEE YSPDKQTWSM RVYTDADAAA AVGAGSLRVN
HLHHQLLATE ASSAKHGGRI VAVDFHQHMV RCFSSSLTAS PSATSSQLQA AGHPLLALDE
GAGVALWYDN AAQRVLVADV VEERVQQRYR NWSALLEGSV NQIGAAASTP RQSLSMTYST
PRKKPSGTLK HGKEDNEEHH GGNTYAGGTG GTDTAGLGGL VGPYRLDKGW PVHQVSPDEK
RRVPPHIIEE AKRMGKAALE ERLREIGMSA REYEQYRSLR ERVQAPVALL RSLLSGLKAA
EGERTWLRGQ TDGVWDDSKI VEGIVGERNI YKRRADSTET NPFQSKHKKR LLFVLDVSAS
MYRFEGMDHR LTKLLESTVM IMEAFAGFED KIDYALVGHN GDSACIELVP FGHPSANQKA
RMEVCQRMVA HAQYCWSGDN TVEAMRQSVD LVTAGKGDAY LVFVISDANL TRYGISPREL
GAIMRSHREV QMFCIFIATL GEQAENLQAD MLPGHSFECF DTQALPHILK QIFVSVNLL
//
