ID   A0A061J2X9_TRYRA        Unreviewed;       742 AA.
AC   A0A061J2X9;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Generic methyltransferase {ECO:0000313|EMBL:ESL08665.1};
GN   ORFNames=TRSC58_03629 {ECO:0000313|EMBL:ESL08665.1};
OS   Trypanosoma rangeli SC58.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX   NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL08665.1, ECO:0000313|Proteomes:UP000031737};
RN   [1] {ECO:0000313|EMBL:ESL08665.1, ECO:0000313|Proteomes:UP000031737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC58 {ECO:0000313|EMBL:ESL08665.1,
RC   ECO:0000313|Proteomes:UP000031737};
RA   Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA   Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA   Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA   de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA   Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA   Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA   Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00037882}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESL08665.1}.
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DR   EMBL; AUPL01003629; ESL08665.1; -; Genomic_DNA.
DR   EnsemblProtists; ESL08665; ESL08665; TRSC58_03629.
DR   VEuPathDB; TriTrypDB:TRSC58_03629; -.
DR   OrthoDB; 1416at2759; -.
DR   Proteomes; UP000031737; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR024775; DinB-like.
DR   InterPro; IPR027625; OvoA_Cterm.
DR   InterPro; IPR027577; OvoA_Nterm.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR005532; SUMF_dom.
DR   InterPro; IPR042095; SUMF_sf.
DR   NCBIfam; TIGR04345; ovoA_Cterm; 1.
DR   NCBIfam; TIGR04344; ovoA_Nterm; 1.
DR   PANTHER; PTHR23150:SF26; METHYLTRANSFERASE, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR23150; SULFATASE MODIFYING FACTOR 1, 2; 1.
DR   Pfam; PF12867; DinB_2; 1.
DR   Pfam; PF03781; FGE-sulfatase; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Methyltransferase {ECO:0000313|EMBL:ESL08665.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW   Transferase {ECO:0000313|EMBL:ESL08665.1}.
FT   DOMAIN          55..195
FT                   /note="DinB-like"
FT                   /evidence="ECO:0000259|Pfam:PF12867"
FT   DOMAIN          229..488
FT                   /note="Sulfatase-modifying factor enzyme"
FT                   /evidence="ECO:0000259|Pfam:PF03781"
SQ   SEQUENCE   742 AA;  85727 MW;  E50A8A8170A7A5B6 CRC64;
     MSSLTLKHYS QMEAERRFRL PTGRDLFHQR IPTVREGDTK QKMEEIRLYV HNTMDLYEKV
     FECVGTEEAF FVQPVHKLRH PLIFYYGHTA CFYINKLCAA GFLKHINPRF EEAFAVGVDE
     MSWDDLNEEH YSWPTVDEVT EYRRAVRDHV NELISSGVYE LNLPLTFENS TASPNNSFWW
     VILMCAEHER IHVETASVHV RELPMRFINR VMSSFWQRCH EVSSKAPVNE LIEVCGGKVH
     VGREPNSLVY GWDCDYSDGN YVIDVPTFKA SKYVVSNAEF MAFIKADGYN TQRYWDEEGW
     KWVQWKKPQH PWFWVRDESH PDGYALRLQT ELIDLPWNWP CELNNLEAHA FCRFKTEKTG
     NNIRMLTEAE WLLLWDRYVG RDQMCWENEA PGNVNLEHFQ SSCPVDKFQH GAFFDIVGNV
     WQHCETKVYP YPGYNVHPFY DDFSMPTFDG RHACMKGGTW VSSGNEATRD ARFAFRRHFF
     QYIGLRYVEA GPANEERYYR SVLGLDPEVD ILTEVSFGEP VNGIPNGCVK IAEYAMAQFK
     AYAKVEARCA LDFACGAGRV SFEMSVFFGR VIGADFTARH LIPAYALLER GTCTYSILDA
     SSQQRVGRLA EASNYSWDDT RNRVTFFQSD PANLHSHMTN FSLIVCWNTL ERALAPAAVP
     PHLLSRLEEG GLLVIGGQYE WIEGRSPVKE YWDATGLSGL VFRVEVNVLS STWXRRCSGR
     VRGSDPSYGG SVGPYRSRRS VR
//