ID   A0A061J6Z8_TRYRA        Unreviewed;       517 AA.
AC   A0A061J6Z8;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=TFIIS N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TRSC58_02352 {ECO:0000313|EMBL:ESL09921.1};
OS   Trypanosoma rangeli SC58.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX   NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL09921.1, ECO:0000313|Proteomes:UP000031737};
RN   [1] {ECO:0000313|EMBL:ESL09921.1, ECO:0000313|Proteomes:UP000031737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC58 {ECO:0000313|EMBL:ESL09921.1,
RC   ECO:0000313|Proteomes:UP000031737};
RA   Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA   Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA   Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA   de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA   Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA   Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA   Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESL09921.1}.
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DR   EMBL; AUPL01002352; ESL09921.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A061J6Z8; -.
DR   EnsemblProtists; ESL09921; ESL09921; TRSC58_02352.
DR   VEuPathDB; TriTrypDB:TRSC58_02352; -.
DR   OrthoDB; 162834at2759; -.
DR   Proteomes; UP000031737; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   CDD; cd05162; PWWP; 1.
DR   Gene3D; 2.20.25.10; -; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   InterPro; IPR042778; ZCWPW1/ZCWPW2.
DR   InterPro; IPR001222; Znf_TFIIS.
DR   PANTHER; PTHR15999; UNCHARACTERIZED; 1.
DR   PANTHER; PTHR15999:SF2; ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1; 1.
DR   Pfam; PF00855; PWWP; 1.
DR   Pfam; PF01096; TFIIS_C; 1.
DR   SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR   SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR   PROSITE; PS50812; PWWP; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          5..37
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|PROSITE:PS50812"
FT   DOMAIN          245..330
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51319"
FT   REGION          94..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..133
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..199
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   517 AA;  57500 MW;  4E2740E47C94F755 CRC64;
     MVFPLNTLVW LKQPEYPWWP GMVLDPATLE MVVPAGYDTC VLCLPSASSS VAFANSSNTE
     ELIRFSPETD AELLEAGKES SECAAAIEEA LSVYRQQTQG KEEEEEGRGS AEHRDEERKG
     RHARKGDAPR RTAKHETKRH KRRERNESPP MERRLRHENK KSDKRKYKEY NDAESDTTED
     LIESDDDRKG SKRTRNKPGK METIGAVDQY DKESRYVPTH QEEDAVYLEH VFRERRQTAS
     DATLQIIRNK LEALIVACNH GGVISVSEAA EEALLDALSP LSLVNITLDQ LHRLKIGVVV
     GKFLMKDYPV RVVSLASAIL TYWFRQLPPA TQQRLSAQSA LELASNETTI GSECQGRSLG
     ALGVQLEACF TDEEVYDTMN EPVVVARGIE TELEAIGDED VSKEVLTALR DSQNTALRRG
     LLDGSVTANE LVANLGNPNA LLRGTDAFSP SVSGRSPVEP ESPLADGHDF TNFTTLYACP
     ECGAREAIAN EYSVQAHDNM AVFVRCLKCG ETWNVET
//